个人简历

徐斌，教授、博士生导师，中国医科大学“登峰学者”，沈阳市“拔尖人才”，环境物理因素与健康研究室主任。
教育经历
1997-2002年：中国医科大学 预防医学 本科
2002-2005年：中国医科大学 劳动卫生与环境卫生学 硕士
2007-2010年：中国医科大学 劳动卫生与环境卫生学 博士
工作经历
2005-2007年：中国医科大学 公共卫生学院 环境卫生教研室 助教
2007-2012年：中国医科大学 公共卫生学院 环境卫生教研室 讲师
2012-2017年：中国医科大学 公共卫生学院 环境卫生教研室 副教授
2015年：美国杜克大学 Multidisciplinary Neuroprotection Laboratories 访问学者
2018年至今： 中国医科大学 公共卫生学院 环境卫生教研室 教授
2018年11月至今： 中国医科大学 公共卫生学院 环境物理因素与健康研究室 主任
主持课题情况
1. 国家自然科学基金面上项目：神经细胞内蛋白质量控制系统对锰诱导α-Synuclein蛋白寡聚化的影响及其分子机制研究。2018-2021年； 60万元。
2. 国家自然科学基金面上项目：Alpha-synuclein与Rab3a蛋白的相互作用及其对锰干扰氨基酸类神经递质释放的影响。2014-2017年；70万元。
3. 辽宁省高等学校杰出青年学者成长计划. 2014-2017年；12万元。
4. 国家自然科学基金青年基金项目：α-synuclein可溶性寡聚体在锰致神经细胞损伤中的作用及其形成机制。2012-2014年；22万元。
研究生培养情况
硕士招生：2014年开始，共招收14人。
博士招生：2016年开始，共招收5人。

研究领域

环境神经毒理学。""

近期论文

1.Kang RR, Sun Q, Chen KG, Cao QT, Liu C, Liu K, Ma Z, Deng Y, Liu W, Xu B*. Resveratrol prevents benzo(a)pyrene-induced disruption of mitochondrial homeostasis via the AMPK signaling pathway in primary cultured neurons. Environmental Pollution, 2020, 261: 114207 doi: 10.1016/j.envpol.2020.114207
2.Liu C, Yan DY, Wang C, Ma Z, Deng Y, Liu W, Xu B*. IRE1 signaling pathway mediates protective autophagic response against manganese-induced neuronal apoptosis in vivo and in vitro. Science of The Total Environment, 2020, 712: 136480 doi: 10.1016/j.scitotenv.2019.136480.
3.Ma Z, Wang C, Liu C, Yan DY, Xuan T, Liu K, Jing MJ, Deng Y, Liu W, Xu B*. Manganese induces autophagy dysregulation: The role of S-nitrosylation in regulating autophagy related proteins in vivo and in vitro. Science of The Total Environment, 2020, 698:134294 doi: 10.1016/j.scitotenv.2019.134294.
4.Liu C, Yan DY, Wang C, Ma Z, Deng Y, Liu W, Xu B*. Manganese activates autophagy to alleviate endoplasmic reticulum stress–induced apoptosis via PERK pathway. J Cell Mol Med. 2020, 24(1):328–341.
5.Jing MJ, Liu K, Liu C, Yan DY, Ma Z, Wang C, Deng Y, Liu W, Xu B*. Protective effects of trehalose against Mn‐induced α‐synuclein oligomerization in mice: Involvement of oxidative stress and autophagy. Environ Toxicol. 2020, 35(1):55–65.
6.Liu K, Jing MJ, Liu C, Yan DY, Ma Z, Wang C, Deng Y, Liu W, Xu B*. Effect of trehalose on manganese‐induced mitochondrial dysfunction and neuronal cell damage in mice. Basic Clin Pharmacol Toxicol. 2019, 125(6):536–547.
7.Yan DY, Liu C, Tan X, Ma Z, Wang C, Deng Y, Liu W, Xu ZF, Xu B*. Mn-Induced Neurocytes Injury and Autophagy Dysfunction in Alpha-Synuclein Wild-Type and Knock-Out Mice: Highlighting the Role of Alpha-Synuclein. Neurotox Res. 2019, 36(1), 66-80.
8.Yan D, Ma Z, Liu C, Wang C, Deng Y, Liu W, Xu B*. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells. Food Chem Toxicol. 2019, 124:336-348.
9.Wang C, Ma Z, Yan DY, Liu C, Deng Y, Liu W, Xu ZF, Xu B*. Alpha-Synuclein and Calpains Disrupt SNARE-Mediated Synaptic Vesicle Fusion During Manganese Exposure in SH-SY5Y Cells. Cells 2018, 7(12), 258.
10.Wang TY, Ma Z, Wang C, Liu C, Yan DY, Deng Y, Liu W, Xu ZF, Xu B*. Manganese-induced alpha-synuclein overexpression impairs synaptic vesicle fusion by disrupting the Rab3 cycle in primary cultured neurons. Toxicol Lett. 2018，285:34-42.
11.Liu C, Yan DY, Tan X, Ma Z, Wang C, Deng Y, Liu W, Yang TY, Xu ZF, Xu B*. Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization Environ Toxicol. 2018，33(3):315-324.
12.Ma Z, Wang C, Liu C, Yan DY, Deng Y, Liu W, Yang TY, Xu ZF, Xu B*. The role S-nitrosylation in manganese-induced autophagy dysregulation in SH-SY5Y cells. Environ Toxicol. 2017，32(12):2428-2439.
13.Wang C, Xu B*, Ma Z, Liu C, Deng Y, Liu W, Xu ZF. Inhibition of Calpains Protects Mn-Induced Neurotransmitter release disorders in Synaptosomes from Mice: Involvement of SNARE Complex and Synaptic Vesicle Fusion. Scientific Reports. 2017, 7(1): 3701.
14.Wang C, Xu B*, Song QF, Deng Y, Liu W, Xu ZF. Manganese exposure disrupts SNARE protein complex-mediated vesicle fusion in primary cultured neurons. Environ Toxicol， 2017, 32(2):705-716.
15.Xu B*, Liu W, Deng Y, Yang TY, Feng S, Xu ZF. Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. PLoS One. 2015, 10(3): e0119205.
16.Xu B*, Jin CH, Deng Y, Liu W, Yang TY, Feng S, Xu ZF. Alpha-Synuclein Oligomerization in Manganese-Induced Nerve Cell Injury in Brain Slices: A Role of NO-Mediated S-Nitrosylation of Protein Disulfide Isomerase. Mol Neurobiol. 2014, 50(3): 1098-1110.
17.Xu B*, Wang F, Wu SW, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. Alpha-Synuclein is Involved in Manganese-Induced ER Stress via PERK Signal Pathway in Organotypic Brain Slice Cultures. Mol Neurobiol. 2014, 49(1): 399-412.
18.Xu B*, Shan M, Wang F, Deng Y, Liu W, Feng S, Yang TY, Xu ZF. Endoplasmic reticulum stress signaling involvement in manganese-induced nerve cell damage in organotypic brain slice cultures. Toxicol Lett. 2013, 222(3):239-246.
19.Xu B*, Wu SW, Lu CW, Deng Y, Liu W, Wei YG, Yang TY, Xu ZF. Oxidative stress involvement in manganese-induced alpha-synuclein oligomerization in organotypic brain slice cultures. Toxicology. 2013, 305:71-78.
20.Xu B, Xu Z*, Deng Y, Liu W, Yang H, Wei YG. MK-801 protects against intracellular Ca(2+) overloading and improves N-methyl-D-aspartate receptor expression in cerebral cortex of methylmercury-poisoned rats. Journal of Molecular Neuroscience. 2013, 49(1):162-171.
21.Xu B, Xu ZF*, Deng Y, Liu W, Yang HB, Wei YG. Protective effects of mk-801 on methylmercury-induced neuronal injury in rat cerebral cortex: Involvement of oxidative stress and glutamate metabolism dysfunction. Toxicology. 2012, 300(3): 112-120.
22.Xu B, Xu ZF*, Deng Y. Protective Effects of MK-801 on Manganese-Induced Glutamate Metabolism Disorder in rat striatum. Exp Toxicol Pathol. 2010, 62(4): 381-390.
23.Xu B, Xu ZF*, Deng Y. Manganese exposure alters the expression of N-methyl-d-aspartate receptor subunit mRNAs and proteins in rat striatum. J Biochem Mol Toxicol. 2010, 24(1): 1-9.
24.Xu B, Xu ZF*, Deng Y, Yang JH. Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo. Exp Toxicol Pathol. 2010, 62(1): 27-34.
25.Xu B, Xu ZF*, Deng Y. Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Neurotoxicology. 2009, 30(6): 941-949.