魏敏杰
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魏敏杰教授,中国医科大学药学院院长、药理学教研室主任。国家二级教授,博士研究生导师,美国芝加哥大学博士后,英国女王大学荣誉教授。人才称号:获评中组部“万人计划”领军人才(教学名师)、辽宁省优秀专家、辽宁省巾帼建功标兵、辽宁省特聘教授、辽宁省教学名师、辽宁省五一劳动奖章、沈阳盛京人才计划的杰出人才、沈阳市高校师德先进个人、辽宁省大学生创新创业年会优秀指导教师等荣誉称号,享受国务院政府特殊津贴。团队业绩:带领团队获得国家教育部“黄大年式”教师团队、国家中医药管理局中医药科研实验室中药药理三级实验室(最高级)、辽宁省高等学校《基于多靶点的个性化生物标志物及创新药物药理学研究》创新团队、辽宁省《分子靶向抗肿瘤药物药理学研究与评价》重点实验室、辽宁省教育系统先进集体。平台基地:作为负责人,带领学科获批“辽宁省高校生物医药产业化服务基地”、辽宁省《研究生药学医药协同与创新实训规范化培训基地》、辽宁省《大学生临床药学创新创业实践教育基地》、辽宁省《临床药学实验教学示范中心》、辽宁省《高等学校对接产业集群协同创新基地》、辽宁省《虚拟仿真实验教学中心》、辽宁省普通高等学校本科重点支持专业《临床药学专业》、中国医科大学《创新药物与精准医学国际研究中心》、中国医科大学《药品食品检验检测中心》等。教学业绩:(1)课程建设:国家精品资源共享课程《药理学》、/省精品课程《药理学》、/省精品课程《药代动力学》;(2)专著:参加国家规划教材及专著编写34部,主编“十三•五”国家级规划教材《药理学》、《临床药理学》等11部;(3)教学课题:承担含中华医学会教育研究课题在内的教学课题13项;(4)教学获奖:获“第五届全国教育改革创新优秀教师奖”及中华医学会教育分会教学成果二等奖等21项;(5)指导学生:指导的研究生多人次获省级优秀毕业论文,指导的本科生获全国大学生创新论坛暨实验设计大赛一等奖、二等奖等11项。科研业绩:(2)研究课题:先后承担含国家自然科学基金9项(其中重点项目1项)、国家科技部“重大新药创制专项”子课题6项、其他各类纵向科研课题近40项;(3)研究论文:发表“Cell Stem Cell”、“Cancer Research”等SCI收录论文近100篇,总IF>350,他引>2000次。成果转化:(1)申请国家发明专利26项,授权3项;(2)沈阳市双百工程项目2项(科技成果转化项目及科技创新项目各1项);(3)作为第一获奖人,研究成果获教育部科技成果奖、辽宁省科技进步奖多项。承担教学课题:(共13项)国家级教改课题1) 中华医学会医学教育分会和中国高等教育学会医学教育专业委员会2016年医学教育研究立项重点课题:《我国高等药学人才培养模式的研究》(2016A-YX003)2) 中华医学会医学教育分会、中国高等教育学会医学教育专业委员会2010年度医学教育研究立项课题—药理学教学团队建设与研究(2010-10-05),2011.01-2013.123) 中华医学会医学教育分会、中国高等教育学会医学教育专业委员会2010年度医学教育研究立项课题—医学整合班药理学PBL课程教学改革的研究与实践(2010-13-09),2011.01-2013.124) 国家教育部教学改革专项课题—《地方医学本科院校应用型人才培养模式的研究与实践》子课题—“修订药学专业教学计划促进应用型药学人才培养的研究与实践”,2006.10-2007.10中美医学会(CMB)教改课题1) 中国医科大学“十二五”第四批医学教育科学研究立项课题—《以创新实践能力为目标的临床药学专业人才培养模式的构建与实施》,2014.01-2016.122) 中国医科大学CMB 08-935子课题—《PBL教学方法在药理学整合班教学中的应用》(0893506),2009.09-2010.12,1.0万3) 中国医科大学CMB 03-793子课题—《传统讲授模式与PBL模式相结合在药理学教学中的应用》,2007.09-2008.12,1.0万4) 中国医科大学CMB 03-793子课题—《PBL授课方式在药理学教学中的应用》,2007.09-2008.12,1.0万5) 中国医科大学CMB 03-793子课题—《药理学教学改革中PBL教学方法的尝试》,2005.09-2006.12,1.0万省级教改课题1) 辽宁省普通高等教育学会外语教学改革专项课题——《国际英语留学生药理学PBL教学改革尝试》(WYZD150041),2015.01-2017.122) 辽宁省教育科学“十二五”规划立项课题—《以创新实践能力为目标的临床药学专业人才培养模式的构建与实施》(JG14DB456),2014.01-2016.123) 辽宁省普通高等教育本科教学改革研究项目—《临床药学专业创新实践能力人才培养模式探索》(UPRP20140821),2014.01-2016.124) 辽宁省教育科学“十二五”规划2011年度一般课题—《PBL教学法在医学药理学整合课程的应用与研究》(JG11DB315)3. 教学成果及奖励(共20项)1) 第五届全国教育改革创新优秀教师奖”,2018年2) 中华医学会医学教育分会,中国高等教育学会医学教育专业委员会,2015年度医学教育和医学教育管理百篇优秀论文评选二等奖——《临床药学专业本科生实习前实践教学模式的改革探索》,通讯作者,2016年12月3) 辽宁省普通高等学校本科大学生动植物标本制作大赛二等奖——《清平乐》,获奖学生:吴珊珊,卢昊,陈新,指导教师:魏敏杰,20164) 指导的学生熊佳、姜新海、王晨、石岳泉完成的项目《基于肺癌细胞多靶点互联网共享的个性化抗肿瘤药物筛选平台》获辽宁省首届“互联网+”大学生创新创业大赛创意奖、成功参赛奖5) 辽宁省普通高等学校本科大学生动植物标本制作大赛二等奖——《梗梗于心-大鼠心肌梗死标本》,获奖学生:贾鹏宇,沈梓琪,王琳琳,指导教师:魏敏杰,20156) 辽宁省普通高等学校本科大学生动植物标本制作大赛二等奖——《绚烂森林》,获奖学生:殷鑫,那芷菁,王瑀珊,指导教师:魏敏杰,20157) 辽宁省普通高等学校本科大学生动植物标本制作大赛优秀奖—《年年有“鱼”》,获奖学生:闻靖,王琳琳,林子淇,指导教师:魏敏杰,20148) 辽宁省高等教育学会十二五中期高等教育研究优秀学术成果三等奖—《基于以问题为基础的药理学教学模式效果评价》(2013LB3259),第一获奖者,2013年9) 中华医学会教育分会暨中国高等医学教育医学会教育专业委员会教学成果二等奖—《医学整合班药理学PBL课程教学改革的研究与实践》,第一获奖者,2012年10) 全国高等医学教育科学研究年会二等奖—《七年制医学生药理学PBL双语教学改革探索与实践》(20100806),第一获奖者,2010年11) 辽宁省教育软件大赛高等教育组二等奖—多媒体课程《怎么又发烧了呢》(2013LNG0241),第一获奖者,2013年10月12) 辽宁省教育软件大赛高等教育组优秀奖—多媒体课程《传出神经系统药理学概论》(2013LNG0538),第三获奖者,2013年13) 辽宁省教育评价协会首届优秀教育研究成果三等奖—《PBL在药理学教学改革中的实践与发展》(0902072),第一获奖者,2010年14) 辽宁省教育厅教学成果三等奖—《传统讲授模式与PBL模式相结合在药理学教学中的应用》,第一获奖者,200915) 教学论文《医学类院校药理学PBL和LBL教学结合探索》获银川PBL教学研讨会二等奖,第一获奖者,201016) 中国医科大学整合课程教改成果二等奖—《PBL教学方法在药理学整合教学中的应用》,第一获奖者,2011年17) 中国医科大学整合课程教改成果二等奖—《PBL与LBL相结合在药理学教学中的应用》,第一获奖者,2010年18) 中国医科大学教学成果一等奖—《PBL在药理学教学改革中的实践与发展》项目,第一获奖者,2008年19) 中国医科大学CMB 03-793项目第二批PBL子课题二等奖—《传统讲授模式与PBL模式相结合在药理学教学中的应用》,第一获奖者,2007年20) 教学论文《五年制医学生药理学PBL教学模式改革》获台北两岸三地药理学会议二等奖,第一获奖者,200921) 两岸三地药理学会议二等奖—《七年制医学生药理学PBL双语教学改革探索》,第一获奖者,2008年4. 本科生实验创新团队培养及获奖1) 高等学校国家级实验教学示范中心联席会,第五届全国大学生基础医学创新论坛暨试验设计大赛试验设计一等奖—《mtROS调控PDI/GRP78互作介导乳腺癌干细胞特性的分子机制》,2018,指导教师:魏敏杰,何苗。学生:赵闻侠、孙晓雨、李翊铭、国文2) 高等学校国家级实验教学示范中心联席会,第五届全国大学生基础医学创新论坛暨试验设计大赛试验设计二等奖—《肿瘤相关抗原E蛋白双表位多肽诱导CTL细胞与Th1细胞抗大肠癌作用研究》,2018,指导教师:魏敏杰、于兆进。学生:刘恩硕、熊佳、王浩菲、施晨3) 指导的熊佳、王浩菲、吴雨桐、徐照旭、张天姝等同学参与的学术论文《p65激活miR-487a靶向抑制MAGI2促进TGF-β诱导乳腺癌细胞EMT》在第十三届“挑战杯”辽宁省大学生课外学术科技作品竞赛中荣获二等奖,20174) 指导的熊佳、徐照旭、吴雨桐、刘恩硕、闻靖等同学参与的学术论文《p65激活miR-487a靶向抑制MAGI2促进TGF-β诱导乳腺癌细胞EMT》在厦门举行的第九届全国大学生创新创业年会上进行学术交流,20165) 指导的徐照旭、熊佳、吴雨桐、刘恩硕、闻靖、林子淇等同学参与的学术论文《p65激活miR-487a靶向抑制MAGI2促进TGF-β诱导乳腺癌细胞EMT》获辽宁省第三届大学生创新创业年会“优秀论文”奖6) 第四届全国大学生基础医学创新论坛暨试验设计大赛创新论坛组二等奖—《乳腺癌相关抗原AGR2的HLA-A2.1限制性CTL优势表位的筛选与鉴定》,2016,指导教师,学生:熊佳、徐照旭、吴雨桐、刘恩硕、闻靖、石岳泉7) 第四届全国大学生基础医学创新论坛暨试验设计大赛实验设计组二等奖—《LINC00473以ceRNA方式双靶向调控WNT1/TCF4介导乳腺癌干细胞特性的分子机制》,2016,指导教师,学生:那芷菁、杨淑德、孙伊婷、肖瑶、邵伊宁8) 中国医科大学基础医学创新论坛暨实验设计大赛论坛组二等奖—《乳腺癌相关抗原AGR2的HLA-A2.1限制性CTL优势表位的筛选与鉴定》,2016,指导教师,学生:熊佳、刘恩硕、徐照旭、吴雨桐、石岳泉、闻靖9) 中国医科大学基础医学创新论坛暨实验设计大赛设计组二等奖—《LINC00473以ceRNA方式双靶向调控WNT1/TCF4介导乳腺癌干细胞特性的分子机制》,2016,指导教师,学生:那芷菁、杨淑德、孙伊婷、肖瑶、邵伊宁10) 基于盐诱导效应的纳米磁颗粒LNA探针快速检测基因SNPs的新型分子诊断试剂研究,组长:孙伊婷11) 高等学校国家级实验教学示范中心联席会,第三届全国大学生基础医学创新论坛暨试验设计大赛试验设计三等奖—《Hedgehog信号通路介导乳腺癌干细胞药物敏感性的研究》,2014,指导教师:魏敏杰,何苗。学生:赵欣楠,高雅,聂昕时,孙子懿,李英研,周晓丹,田冰12) 中国医科大学基础医学创新论坛暨实验设计大赛二等奖—《Hedgehog信号通路在盐霉素抑制乳腺癌干细胞增殖中的作用》,2013,指导教师13) 中国医科大学基础医学创新论坛暨实验设计大赛二等奖—《miR-302-367基因簇高表达协同逆转乳腺癌细胞耐药性的研究》,2013,指导教师:魏敏杰。学生:14) 中国医科大学基础医学创新论坛暨实验设计大赛二等奖—《H2S抑制M2型肿瘤相关巨噬细胞极化的分子机制》,2013,指导教师15) 高等学校国家级实验教学示范中心联席会,第二届全国大学生基础医学创新论坛暨试验设计大赛试验设计一等奖—《miR-181a靶向抑制BCRP逆转乳腺癌细胞耐药》,2012,指导教师:魏敏杰。学生:周明祎,李嘉姝,杜志成16) 高等学校国家级实验教学示范中心联席会,第二届全国大学生基础医学创新论坛暨实验设计大赛试验设计二等奖—《FANCF沉默通过激活JNK和p38通路增加乳腺癌细胞对米托蒽醌的敏感性》,2012,指导教师,指导教师:魏敏杰。学生:吕沐天,张杉杉,王俊,崔龙,聂兆超17) 高等学校国家级实验教学示范中心联席会,第二届全国大学生基础医学创新论坛暨实验设计大赛试验设计二等奖—《肿瘤相关巨噬细胞与乳腺癌耐药》,2012,指导教师:魏敏杰。学生:刘盛业,周明祎18) 高等学校国家级实验教学示范中心联席会,第二届全国大学生基础医学创新论坛暨试验设计大赛试验设计三等奖—《 EGCG抑制炎性因子表达改善APP/PS1双转基因小鼠学习记忆障碍的分子机制》,2012,指导教师:魏敏杰。学生:曾庆东,杜志成,刘洋,张朕杰,詹晓妮19) 高等学校国家级实验教学示范中心联席会,首届全国大学生基础医学创新论坛暨试验设计大赛试验设计二等奖—《盐霉素对CD44+/24-乳腺癌干细胞靶向杀伤作用》,2010,指导教师:魏敏杰。学生:姚鲁田,陶林,刘航20) 高等学校国家级实验教学示范中心联席会,首届全国大学生基础医学创新论坛暨试验设计大赛试验设计二等奖—《EGCG防治APP/PS1双转基因鼠AD作用的机制研究》,2010,指导教师:魏敏杰。学生:陶林,刘航,朱政,姚鲁田,杜志成科研成果及奖励1) 辽宁省医学科技奖一等奖—《基于医药大数据的乳腺癌药物敏感性特异调控网络的应用研究》,第一获奖者,辽宁省医学会,2016年10月12日,2016-1-02-012) 沈阳市科技进步奖一等奖—《介导乳腺癌药物敏感性特异标志物与调控网络的基础与临床研究》,第一获奖者,沈阳市人民政府,2017年1月,2016J-1-14-13) 辽宁省科学技术奖励二等奖—《BRCA1与散发性乳腺癌的相关性及调控机制研究》(2010J-2-69-01),第一获奖者,2010年4) 教育部科技成果—《散发性乳腺癌发生和耐药的相关性机制研究》(360-08-18040543-01),第一获奖者,2008年5) 辽宁省科学技术奖励二等奖—《化合物毒性预测专家系统V1.02》(2012J-2-78-08),2012年7月6) 中国工程院2014年医学科学前沿论坛第十四次全国临床药理学学术会议受邀获荣誉证书,2014年7) 2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议优秀论文奖—《ECM1抗原HLA-A2.1限制性CTL表位鉴定》,指导教师,2015年8) 2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议优秀论文奖—《mTOR启动子单倍体变异影响乳腺癌易感性及预后的机制研究》,指导教师,2015年9) 第十二届全国化疗药理学术研究会青年优秀论文二等奖—《miR-181a通过靶向抑制乳腺癌耐药蛋白(BCRP)表达逆转乳腺癌耐药》,指导教师,2014年10) 中国药理学会第十一届全国化疗药理学术研讨会优秀论文二等奖—《FANCF基因沉默通过激活JNK和P38信号通路增加乳腺癌细胞对米托蒽醌的敏感性》,指导教师,2012年11) 2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会优秀论文奖—《Gene Silencing of FANCF Potentiates the Sensitivity of Mitoxantrone in Breast Cancer Cells via a p53 dependent way》,指导教师,2012年12) 卫生部杰出青年研究者科研基金奖励,1999年13) 研究课题《人子宫平滑肌M受体及亚型的研究》获辽宁省教育委员会科技进步奖二等奖(98021-1),第一获奖者,1998年14) 研究课题《肺动脉高压鼠肺动脉平滑肌细胞内钙的检定》获辽宁省教育委员会科技进步奖一等奖(98018-7),第七获奖者,1998年15) 研究课题《肺动脉高压鼠肺动脉平滑肌细胞内钙的检定》获国家教育部科技进步二等奖,1999年16) 中国医科大学十佳科技之星,1998年17) 论文《Influence of tetramethylpyrazine on pulmonary microcirculation in anesthetized bullforgs》, 获第一届亚洲微循环学会优秀论文奖,1993年18) 论文《川芎嗪对离体大鼠肺动脉的作用及机理探讨》获辽宁省首届优秀青年科技论文二等奖,1992年4. 专利申请/授权情况1) 魏敏杰,孙明立,于兆进,陈秋晨,与MHC-I类分子结合的GRP78多肽表位,申请号:201310655527.3;授权专利号:ZL201310655527.3;授权公告日,2017年2月8日2) 魏敏杰,于兆进,孙明立,陈秋晨,与MHC-I类分子结合的ECM1多肽表位,申请号:201310654784.5;授权专利号:ZL201310654784.5,授权公告日,2016年9月28日3) 魏敏杰,刘明妍,钟欣,姚维范,王爽,王崴,赵琳,何苗,赵海山,一种治疗阿尔茨海默病的药物复合制剂,申请日:2013年8月14日,申请号:201310356333.3;授权专利号:ZL2013 1 0356333.3,授权公告日,2016年6月8日,中华人民共和国国家知识产权局4) 魏敏杰,魏斌斌,刘明妍,《一种五味子醇甲衍生物及其制备方法和用途》,中国,专利申请号:201810125771.15) 魏敏杰,于丽凤,赵琳,一种多肽及其用途,申请号:201810013702.1,申请时间:2018.1.86) 魏敏杰,赵琳,卫倩,一种肿瘤靶向的新型多肽及其用途,申请号:2018100133370.0,申请时间:2018.2.97) 赵琳,魏敏杰,张继红,宋昕樾.,一种IDH2突变型的小分子抑制剂及其应用,申请号:201810141476.5,申请时间:2018.2.98) 魏敏杰,颜媛媛,何苗,刘一诺,张丽雯,一种HIF-2α小分子抑制剂及其用途,申请号:201810146778.1,申请时间:2018.2.129) 魏敏杰、杜可、刘明妍,《一种吡喃葡萄糖基取代的EGCG化合物及其制备方法和用途》,2017.11.14,中国,专利申请号:201711121654.X10) 魏敏杰、钱平、刘明妍,《一种提取分离五味子醇甲和五味子醇乙的简易方法》,2017.12.4,中国,专利申请号:20171125606711) 魏敏杰、张晶,一种直接对微小核糖核酸(microRNA)进行半定量的探针,2017. 3,中国,申请号CN201710174873.8。12) 魏敏杰、张晶、吴慧哲、陈秋晨,一种直接对微小核糖核酸100(microRNA100)进行半定量的试剂盒,2017. 3,中国,申请号CN201710173792.6。13) 魏敏杰、张晶、吴慧哲、陈秋晨,一种直接对微小核糖核酸675(microRNA675)进行半定量的试剂盒,2017. 3,中国,申请号CN201710173785.6。14) 魏敏杰,于兆进,孙明立,刘雯思,韩强,赵兰,李亚楠,线云开等,HLA-A2限制性ECM1特异性CTL表位肽及应用,申请号CN20170050501.415) 魏敏杰,孙明立,于兆进,刘雯思,韩强,赵兰,李亚楠,线云开等,HLA-A24限制性ECM1特异性CTL表位肽及应用,申请号CN201710050503.316) 魏敏杰,孙明立,于兆进,李亚楠,刘雯思,赵兰,韩强,线云开,边竞等,一种基于肿瘤抗原ECM1的长肽ERE1及其在肿瘤免疫治疗中的应用,CN201710130387.617) 魏敏杰,李亚楠,孙明立、于兆进、刘雯思、线云开、韩强、赵兰、边竞等,一种抗原肽RL-佐剂CpGODN7009偶联物及其制备方法和应用,申请号CN201710473767.X18) 魏敏杰,一种MHC-I类限制性抗肿瘤CTL表位肽,申请日:2016年2月,申请号:CN201610076778.x19) 魏敏杰、张晶、吴慧哲、陈秋晨、赵鹏飞,一种探针室温下检测耐药基因多态性的试剂盒,2015.6,中国,CN201510387246.320) 魏敏杰、靳鑫、刘明妍、高华、姚维范、毛瑞琨、杨时伦,《一种用氢键型大孔树脂制备高纯度EGCG的方法》,2014.12.12,中国,专利申请号:CN201410766716.221) 魏敏杰、刘明妍、钟欣、姚维范、杨时伦、杜可、赵海山,《一种治疗阿尔茨海默病的药物复合制剂》,2014.12.12,中国,专利申请号:CN201410771475.022) 魏敏杰,吴慧哲,张晶,陈秋晨,一种室温下检测ABCB1 C3435T/A的试剂盒,201410687522.323) 魏敏杰、赵琳、焦旭阳、何苗、吴慧哲、任婕、唐宏涛、赵鹏飞,一种应用miR-181a逆转乳腺癌耐药的方法,2013.2,中国,201310049732.524) 魏敏杰、何苗、马孟涛、赵琳、白雪峰、于兆进、孙明立、陈秋晨,一种应用miR-487a逆转乳腺癌耐药的方法,2013.2,中国,201310050665.925) 魏敏杰、刘明妍、王爽、陈福军、姚维范、赵海山、陶琳,一种表没食子儿茶素没食子酸酯抗阿尔茨海默病的方式,2012.4,中国,210210118478.526) 魏敏杰、刘明妍、何苗、王爽、赵琳、姚维范、赵海山,一种治疗阿尔茨海默病的药物,2012.4中国,201210119049.X【主要科研成果】1. 承担代表性国家级科研课题1) NSFC-辽宁联合基金重点支持项目—《基于ECM1优势CTL表位双重修饰的多表位长肽-DC疫苗抗三阴性乳腺癌靶向效应与免疫学机制研究》(No.U1608281)2017.01-2020.12,250.0万元,第一负责人2) 国家自然科学基金面上资助项目—《SPRY4-IT1介导SMD途径靶向降解TCEB1调控乳腺癌干细胞特性的分子机制》(No.81673475) 2017.01-2020.12,65.0万元,第一负责人3) 国家自然科学基金面上资助项目—《HIF-2α通过GRP78 介导的内质网应激调控乳腺癌干细胞药物敏感性的机制研究》(No.81373427) 2014.01-2017.12,70.0万元,第一负责人4) 国家自然科学基金资助项目—《miR-302-367基因簇靶向作用BCRP协同调控乳腺癌耐药性的研究》(No. 81173092),2012.01-2015.12,69.0万元,第一负责人5) 国家自然科学基金资助项目—《microRNA-181a对乳腺癌细胞BCRP表达与功能的调控机制》(No.30973559),2010.01-2012.12,36.0万元,第一负责人6) 国家自然科学基金资助项目—《FANCF基因干预乳腺癌细胞耐药性的信号转导机制》(No.30873097),2009.01-2011.12,31.0万元,第一负责人7) 国家自然科学基金资助项目—《子宫内膜癌细胞钙信号转导与抑癌基因表达的相关性研究》(No.30070849),2001.01-2003.12,19.0万元,第一负责人8) 国家自然科学基金资助项目—《人子宫平滑肌毒蕈碱受体后转导机制的研究》(No.39600178),1997.01-1999.12,9.0万元,第一负责人9) 国家自然科学基金资助项目—《人子宫平滑肌M受体的研究》(No.39270774),1993.01-1995.12,5.0万元,第一负责人10) 国家科技部“重大新药创制”专项—《兰索拉唑胃溶胶囊的临床前研究》(No.2014ZX09201002-004),2014.01-2016.12,50万,子课题负责人11) 国家科技部“重大新药创制”科技重大专项—《多靶向抗阿尔茨海默病新药EGCG的开发研究》(No.2013ZX09103001-003),2013.01-2015.12,140.51万元,子课题负责人12) 国家重大新药创制平台—《临床前药效学筛选与评价平台》(No.2009ZX09301-012), 2009.01-2010.12,97.0万元,子课题负责人13) 国家科技部“重大新药创制”科技重大专项—《牛蒡子苷元抗肿瘤作用药效学研究》(No.2009ZX09103-423),2009.01-2010.12,37.0万元,子课题负责人14) 国家科技部“十一五”科技攻关重大专项—《沙棘籽油脂肪乳静脉营养作用药效学研究》,2007.01-2009.12,30.0万元,子课题负责人研究领域
肿瘤免疫细胞治疗与原创性抗肿瘤新药研发与评价;老年痴呆发病机制研究及多靶点新药研发与评价;精准检测新技术建立和服务与新产品研发。""近期论文
1) Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M*, He C*, Chen J*. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. Cell Stem Cell. 2018 Feb 1;22(2):191-205.2) Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J*. Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biol. 2018 Mar;20(3):285-295.3) Du K, Liu M(co-first author), Zhong X, Yao W, Xiao Q, Wen Q, Yang B, Wei M. Epigallocatechin Gallate Reduces Amyloid β-Induced Neurotoxicity via Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis. Mol Nutr Food Res. 2018 Feb 15.4) Shu Lin,Lin Zhao, Xinyue Song, Jing Zhang, Yan Wang, Longyang Jiang, Lifeng Yu, Jia Bi, Minjie Wei. Prognostic value of miRNA-181a in human colorectal cancer evaluated by in situ hybridization. Transl Cancer Res 2018,7(1):121-1345) Yuanyuan Yan, Miao He, Zhaojin Yu, Mingli Sun, Lin Zhao, Haishan Zhao, Weifan Yao, Minjie Wei*. Combined expression of ZEB2 and ALDH1A1 is correlated with poor prognosis of breast cancer patients. Int J Clin Exp Med 2018;11(3):1994-2003.6) Cao Y, Green K, Quattlebaum S, Milam B, Lu L, Gao D, He H, Li N, Gao L, Hall F, Whinery M, Handley E, Ma Y, Xu T, Jin F, Xiao J, Wei M, Smith D, Bornstein S, Gross N, Pyeon D, Song J, Lu SL*. Methylated genomic loci encoding microRNA as a biomarker panel in tissue and saliva for head and neck squamous cell carcinoma. Clin Epigenetics. 2018 Apr 3;10:43.7) Wei BB, Liu MY, Chen ZX, Wei MJ*. Schisandrin ameliorates cognitive impairment and attenuates Aβ deposition in APP/PS1 transgenic mice: involvement of adjusting neurotransmitters and their metabolite changes in the brain. Acta Pharmacol Sin. 2018 Apr;39(4):616-625.8) Du K, Liu MY, Pan YZ, Zhong X, Wei MJ*. Association of circulating manganese levels with Parkinson's disease: A meta-analysis. Neurosci Lett. 2018 Feb 5;665:92-98..9) Zhang Z, Chen Q, Zhang J, Wang Y, Hu X, Yin S, He M, Guan S, Qin W, Xiao Q, Zhao H, Yao W, Wu H*, Wei M*. Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population. Sci Rep. 2017 Dec 19;7(1):17844.10) Su R, Dong L, Li C, Nachtergaele S, Wunderlich M, Qing Y, Deng X, Wang Y, Weng X, Hu C, Yu M, Skibbe J, Dai Q, Zou D, Wu T, Yu K, Weng H, Huang H, Ferchen K, Qin X, Zhang B, Qi J, Sasaki AT, Plas DR, Bradner JE, Wei M, Marcucci G, Jiang X, Mulloy JC, Jin J, He C, Chen J. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell. 2017 Dec 11. pii: S0092-8674(17)31382-X.11) Deng X, Su R, Feng X, Wei M, Chen J*. Role of N6-methyladenosine modification in cancer. Curr Opin Genet Dev. 2017 Oct 14;48:1-7.12) Wang H, Zou L, Ma K, Yu J, Wu H, Wei M, Xiao Q*. Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer. Mol Cancer. 2017 Sep 11;16(1):15213) Zhong X, Liu MY, He M, Du K, Wei MJ*. Association of interleukin-33 gene polymorphisms with susceptibility to late onset Alzheimer's disease: a meta-analysis. Neuropsychiatr Dis Treat. 2017 Aug 30;13:2275-2284.14) Wei BB, Chen ZX, Liu MY, Wei MJ*. Development of a UPLC-MS/MS Method for Simultaneous Determination of Six Flavonoids in Rat Plasma after Administration of Maydis stigma Extract and Its Application to a Comparative Pharmacokinetic Study in Normal and Diabetic Rats. Molecules. 2017, 22(8), 1267-1280.15) Binbin Wei#, Mingyan Liu, Zaixing Chen, Minjie Wei*. UPLC-MS/MS method for determination of schisandrin in rat plasma and brain microdialysates: application to a comparative pharmacokinetic and brain distribution study in normal and Alzheimer’s disease rats. Anal. Methods, 2017, 9, 4740-4746.16) Wu H, Wang H, Guan S, Zhang J, Chen Q, Wang X, Ma K, Zhao P, Zhao H, Yao W, Jin F, Xiao Q*, Wei M*. Cell-specific regulation of proliferation by Ano1/TMEM16A in breast cancer with different ER, PR, and HER2 status. Oncotarget. 2017 Jun 27;8(49):84996-8501317) Du K, Liu MY, Zhong X, Wei MJ. Decreased circulating Zinc levels in Parkinson's disease: a meta-analysis study. Sci Rep. 2017 Jun 20;7(1):3902.18) Du K, Liu M, Pan Y, Zhong X, Wei M*. Association of Serum Manganese Levels with Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis. Nutrients. 2017 Mar 3;9(3).19) Wang S, Ding WG, Bai JY, Toyoda F,Wei MJ, Matsuura H*.Regulation of human cardiac Kv1.5 channels by extracellular acidification. Pflugers Arch. 2016 Nov;468(11-12):1885-1894.20) Zhao H, Tang H, Xiao Q, He M, Zhao L, Fu Y, Wu H, Yu Z, Jiang Q, Yan Y, Jin F, Wei M.*The Hedgehog signaling pathway is associated with poor prognosis in breast cancer patients with the CD44+/CD24- phenotype. Mol Med Rep. 2016 Dec;14(6):5261-5270. 21) Bi J, Zeng X, Zhao L, Wei Q, Yu L, Wang X, Yu Z, Cao Y, Shan F, Wei M*.miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα. Mol Ther Nucleic Acids. 2016 Sep 27;5(9):e368.22) Ma K, Wang H, Yu J, Wei M, Xiao Q*.New Insights on the Regulation of Ca2+-Activated Chloride Channel TMEM16A. J Cell Physiol. 2016 Sep 28. doi: 10.1002/jcp.25621.23) Zhong X, Liu MY, Sun XH, Wei MJ*. Association between ABCB1 polymorphisms and haplotypes and Alzheimer's disease: a meta-analysis. Scientifical Reports. 2016 Sep 7;6:32708.24) Yu J, Zhang J, Xing H, Yang Z, Cai C, Zhang C, Zhao X, Wei M, Yang L, Ding P*. Guanidinylated bioresponsive poly(amido amine)s designed for intranuclear gene delivery. Int J Nanomedicine. 2016 Aug 17;11:4011-2425) Zhao H, Yu Z, Zhao L, He M, Ren J, Wu H, Chen Q, Yao W, Wei M*.HDAC2 overexpression is a poor prognostic factor of breast cancer patients with increased multidrug resistance-associated protein expression who received anthracyclines therapy.Jpn J Clin Oncol. 2016 Oct;46(10):893-902.26) Zhao L, Wang Y, Jiang L, He M, Bai X, Yu L, Wei M*.MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1). J Exp Clin Cancer Res. 2016 Feb 3;35(1):25.27) Ma M, He M(co-first author), Jiang Q, Yan Y, Guan S, Zhang J, Yu Z, Chen Q, Sun M, Yao W, Zhao H, Jin F, Wei M*. MiR-487a promotes TGF-β1-induced EMT, the migration and invasion of breast cancer cells by directly targeting MAGI2. Int. J. Biol. Sci.2016Feb 5; 12(4): 397-408.28) Wang Y, Zhao L, Xiao Q, Jiang L, He M, Bai X, Ma M, Jiao X, Wei M*.miR-302a/b/c/d cooperatively inhibit BCRP expression to increase drug sensitivity in breast cancer cells. Gynecol Oncol. 2016 Jun;141(3):592-601.29) Fu YZ, Yan YY(co-first author), He M, Xiao QH, Yao WF, Zhao L, Wu HZ, Yu ZJ, Zhou MY, Lv MT, Zhang SS, Chen JJ, Wei MJ*.Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway. Oncol Rep. 2016 Feb;35(2):912-92230) Jiang Q, He M, Ma MT, Wu HZ, Yu ZJ, Guan S, Jiang LY, Wang Y, Zheng DD, Jin F,Wei MJ*.MicroRNA-148a inhibits breast cancer migration and invasion by directly targeting WNT-1. Oncol Rep. 2016 Mar;35(3):1425-32.31) Jiang Q, He M, Guan S, Ma M, Wu H, Yu Z, Jiang L, Wang Y, Zong X, Jin F, Wei M*.MicroRNA-100 suppresses the migration and invasion of breast cancer cells by targeting FZD-8 and inhibiting Wnt/β-catenin signaling pathway. Tumour Biol. 2016 Apr;37(4):5001-1132) Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C. AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities. Toxins (Basel). 2015 Jan 23;7(2):219-3733) Wu H, Liu Y, Kang H, Xiao Q, Yao W, Zhao H, Wang E, Wei M*.Genetic Variations in ABCG2 Gene Predict Breast Carcinoma Susceptibility and Clinical Outcomes after Treatment with Anthracycline-Based Chemotherapy.Biomed Res Int. 2015;2015:279109.34) Sun M, Zhao H, Xiao Q, Yu Z, Song Z, Yao W, Tang H, Guan S, Jin F, Wei M*. Combined expression of aldehyde dehydrogenase 1A1 and β-catenin is associated with lymph node metastasis and poor survival in breast cancer patients following cyclophosphamide treatment. Oncol Rep. 2015 Dec;34(6):3163-73.35) Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, Chen J.Overexpression and knockout of miR-126 both promote leukemogenesis through targeting distinct gene signaling.Blood. 2015 Oct 22;126(17):2005-1536) Zhang J, Wu H, Chen Q, Zhao P, Zhao H, Yao W, Wei M*. A Locked Nucleic Acid Probe Based on Selective Salt-Induced Effect Detects Single Nucleotide Polymorphisms. Biomed Res Int. 2015;2015:391070.37) Jin X, Liu M, Chen Z, Mao R, Xiao Q, Gao H, Wei M*. Separation and purification of epigallocatechin-3-gallate (EGCG) from green tea using combined macroporous resin and polyamide column chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 18;1002:113-122.38) He M, Fu Y, Yan Y, Xiao Q, Wu H, Yao W, Zhao H, Zhao L, Jiang Q, Yu Z, Jin F, Mi X, Wang E, Cui Z, Fu L, Chen J, Wei M*. The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients. Clin Sci (Lond). 2015 Nov 1;129(9):809-22.39) Yu Z, Xiao Q, Zhao L, Ren J, Bai X, Sun M, Wu H, Liu X, Song Z, Yan Y, Mi X, Wang E, Jin F, Wei M*. DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor alpha/breast cancer susceptibility gene 1 and poor prognosis. Mol Carcinog, 2015 Sep;54(9):707-19.40) Wu H, Guan S, Sun M, Yu Z, Zhao L, He M, Zhao H, Yao W, Wang E, Jin F, Xiao Q, Wei M*. Ano1/TMEM16A Overexpression Is Associated with Good Prognosis in PR-Positive or HER2-Negative Breast Cancer Patients following Tamoxifen Treatment. PLoS One. 2015 May 11;10(5):e0126128.41) Yu Z, Sun M, Jin F, Xiao Q, He M, Wu H, Ren J, Zhao L, Zhao H, Yao W, Shan F, Cao Y, Wei M*. Combined expression of ezrin and E-cadherin is associated with lymph node metastasis and poor prognosis in breast cancer. Oncol Rep. 2015, 34(1):165-7442) Jiang L, Bai X, Wang Y, Wei M*. Association Between CD24-P226-C/T Polymorphism and Multiple Sclerosis: A Meta-Analysis. Immunol Invest. 2015;44(4):321-30.43) Wang A, Wang J, Sun L, Jin J, Ren H, Yang F, Diao K, Wei M, Mi X. Expression of tumor necrosis factor receptor-assicated factor 4 correlates with expression of Girdin and promotes nuclear translocation of Girdin in breast cancer. Mol Med Rep. 2015 May;11(5):3635-41.44) ZhaoH,WangZ,WuH,XiaoQ,YaoW,WangE,LiuY,WeiM*.STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast cancer risk and clinical outcomes. Med Oncol. 2015 Jan;32(1):375. 45) Ren J, Chen QC, Jin F, Wu HZ, He M, Zhao L, Yu ZJ, Yao WF, Mi XY, Wang EH, Wei MJ*. Overexpression of Rsf-1 correlates with pathological type, p53 status and survival in primary breast cancer. Int J Clin Exp Pathol. 2014 Aug 15;7(9):5595-608. eCollection 2014.46) Liu X, Xiao Q, Bai X, Yu Z, Sun M, Zhao H, Mi X, Wang E, Yao W, Jin F, Zhao L, Ren J, Wei M*. Activation of STAT3 is involved in malignancy mediated by CXCL12-CXCR4 signaling in human breast cancer.Oncol Rep. 2014 Dec;32(6):2760-8.47) Tang Q, Zhao Y, Wang Y, Wei M*. A genetic variant (rs17251221) in the calcium-sensing receptor relates to hepatocellular carcinoma susceptibility and clinical outcome treated by transcatheter hepatic arterial chemoembolization (TACE) therapy.Med Oncol. 2014 Nov;31(11):267.48) Liu MY, Wang S, Yao WF, Zhang ZJ, Zhong X, Sha L, He M, Zheng ZH, Wei MJ*. Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice.Neuroscience. 2014 Jul 25;273:141-5149) Zhao L, Li Y, He M, Song Z, Lin S, Yu Z, Bai X, Wang E, Wei M*. The Fanconi anemia pathway sensitizes to DNA alkylating agents by inducing JNK-p53-dependent mitochondrial apoptosis in breast cancer cells. Int J Oncol. 2014 Jul;45(1):129-38. 50) Zhang Y, Yu Z, Xiao Q, Sun X, Zhu Z, Zhang J, Xu H, Wei M, Sun M*. Expression of BAMBI and its combination with Smad7 correlates with tumor invasion and poor prognosis in gastric cancer. Tumor Biol. 2014 Apr 35:7:7047-56.51) Sun M, Pang L, Ju X, Sun H, Yu J, Zhao H, Yao W, Wei M*. Attenuating effects of omega-3 fatty acids (Omegaven) on irradiation-induced intestinal injury in mice.Food Chem Toxicol. 2014 Feb;64:275-80.52) Sun M, Wang S, Zhao L, Zhao H, Yao W, Jin W, Wei M*. Suppression of 2,4-dinitrochlorobenzene-induced atopic dermatitis by extract of Bacillus Calmette-Guerin.Mol Med Rep. 2014 Feb;9(2):689-94.53) Zhao L, Li N, Yu JK, Tang HT, Li YL, He M, Yu ZJ, Bai XF, Zheng ZH, Wang EH, Wei MJ*. RNAi-mediated knockdown of FANCF suppresses cell proliferation, migration, invasion and drug resistance potential of breast cancer cells. Braz J Med Biol Res.2014 Jan;47(1):24-3454) Bai X, Fu Y, Xue H, Guo K, Song Z, Yu Z, Jia T, Yan Y, Zhao L, Mi X, Wang E, Zheng Z, Zhao H, Yao W, Wei M*. BRCA1 promoter hypermethylation in sporadic epithelial ovarian cancer: associated with BRCA1 low-expression, improved survival and DNMTs. Oncology letters 2014, Apr;7(4):1088-1096.55) Liu M, Chen F, Sha L, Wang S, Tao L, Yao L, He M, Yao Z, Liu H, Zhu Z, Zhang Z, Zheng Z, Sha X, Wei M*. (-)-Epigallocatechin-3-Gallate Ameliorates Learning and Memory Deficits by Adjusting the Balance of TrkA/p75NTR Signaling in APP/PS1 Transgenic Mice. Mol Neurobiol. 2014 Jun;49(3):1350-63.56) Du Q, Hou X, Ge L, Li R, Zhou M, Wang H*, Wang L, Wei M, Chen T, Shaw C.Cationicity-enhanced analogues of the antimicrobial peptides, AcrAP1 and AcrAP2, from the venom of the scorpion, Androctonus crassicauda, display potent growth modulation effects on human cancer cell lines. Int J Biol Sci. 2014 Sep 21;10(10):1097-107. (IF 4.509)57) Wang A,Wang J,Ren H,Yang F,Sun L,Diao K,Zhao Z,Song M,Cui Z,Wang E, Wei M, Mi X.TRAF4participatesin Wnt/β-catenin signaling in breast cancer by upregulating β- catenin and mediating it stranslocation to the nucleus. Mol Cell Biochem.2014 Oct;395(1-2):211-9.58) Liu BJ, Ma LN, Su J, Jing WW, Wei MJ, Sha XZ. Biocompatibility assessment of porous chitosan-Nafion and chitosan-PTFE composites in vivo. J Biomed Mater Res A. 2014 Jun;102(6):2055-6059) Ma MT, He M (co-first author), Wang Y, Jiao XY, Zhao L, Bai XF, Yu ZJ, Wu HZ, Sun ML, Song ZG, Wei MJ*. MiR-487a resensitizes mitoxantrone (MX)-resistant breast cancer cells (MCF-7/MX) to MX by targeting breast cancer resistance protein (BCRP/ABCG2).Cancer Lett. 2013 Oct 1;339(1):107-1560) Yu J, Zhao L, Li Y, Li N, He M, Bai X, Yu Z, Zheng Z, Mi X, Wang E, Wei M*. Silencing of fanconi anemia complementation group f exhibits potent chemosensitization of mitomycin C activity in breast cancer cells.J Breast Cancer. 2013 Sep;16(3):291-9.61) Ren J, Jin F, Yu Z, Zhao L, Wang L, Bai X, Zhao H, Yao W, Mi X, Wang E, Olopade OI, Wei M*. MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency. Tumor Biology. 2013 Dec;34(6):3945-5862) Jiao X, Zhao L (co-first author), Ma M, Bai X, He M, Yan Y, Wang Y, Chen Q, Zhao X, Zhou M, Cui Z, Zheng Z, Wang E, Wei M*. MiR-181a enhances drug sensitivity in mitoxantone-resistant breast cancer cells by targeting breast cancer resistance protein (BCRP/ABCG2).Breast Cancer Res Treat. 2013 Jun;139(3):717-3063) Wu H, Kang H, Liu Y, Xiao Q, Zhang Y, Sun M, Liu D, Wang Z, Zhao H, Yao W, Jia T, Wang E, Zheng Z, Wei M*. Association of ABCB1 genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis. Pharmacogenomics. 2013 Jun;14(8):897-91164) He M, Sun HG (co-first author), Hao JY, Li YL, Yu JK, Yan YY, Zhao L, Li N, Wang Y, Bai XF, Yu ZJ, Zheng ZH, Mi XY, Wang EH, Wei MJ*. RNA interference-mediated FANCF silencing sensitizes OVCAR3 ovarian cancer cells to adriamycin through increased adriamycin-induced apoptosis dependent on JNK activation.Oncol Rep. 2013 May;29(5):1721-9.65) Wang J, Liu Y, Wei MJ, Mi XY, Wang EH. Clinical correlations and prognostic relevance of Fn14 expression in breast carcinoma. 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Gene Silencing of FANCF Potentiates the Sensitivity to Mitoxantrone through Activation of JNK and p38 Signal Pathways in Breast Cancer Cells.PLoS One. 2012;7(8):e44254.70) Bai X, Song Z, Fu Y, Yu Z, Zhao L, Zhao H, Yao W, Huang D, Mi X, Wang E, Zheng Z,Wei M*. Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer. Plos One. 2012;7(6):e40024. Epub 2012 Jun 29(71) Yang XL, Liu D(Co-first author), Wu HZ, Kang H, Pang H, Wang EH, Wei MJ*. Association of XPC polymorphisms with susceptibility and clinical outcome to chemotherapy in breast cancer patients. Cancer science. 2012,103(7):1207-1214 .72) Wu HZ, Kang H, Liu Y, Tong WW, Liu D, Yang XL, Lian YM, Yao WF, Zhao HS, Huang DS, Sha XZ, Wang EH, Wei MJ*. Roles of ABCB1 gene polymorphisms and haplotype in susceptibility to breast carcinoma risk and clinical outcomes. 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Pharmacokinetic properties and bioequivalence of two compound formulations of 1500 mg ampicillin (1167mg) / probenecid (333mg): a randomized- sequence, single- dose,open- label, two- period crossover study in healthy Chinese male volunteers. Clin Ther,2010 Mar;32(3):597-606.81) Kong J, Kim GH, Wei M, Sun T, Li G, Liu SQ, Li X, Bhan I, Zhao Q, Thadhani R, Li YC. Therapeutic effects of vitamin D analogs on cardiac hypertrophy in spontaneously hypertensive rats.Am J Pathol. 2010 Aug;177(2):622-31.82) Zhao L, Wang L, Jin F, Ma W, Ren J, Wen X, He M, Sun M, Tang H, Wei M*. Silencing of Estrogen receptor α (ERα) gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast cancer, Breast Cancer Research and Treatment. 2009 Sep;117(2):253-259.83) Liu MY, Wang S, Yao WF, Wu HZ, Meng SN, Wei MJ*. 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Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers. Breast Cancer Res Treat, 2008 Sep;111(1):113-120.88) Wei M, Grushko TA, Dignam J, Hagos F, Nanda R, Sveen L, Xu J, Fackenthal J, Tretiakova M, Das S, Olopade OI. BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. Cancer Research,2005;65(23):10692-10699.89) Song QB, Wei MJ, Duan ZQ, Zhang HQ, Schwartz LB, Xin SJ. Batroxobin reduces intracellular calcium concentration and inhibits proliferation of vascular smooth muscle cells.Chinese Medical Journal,;117(6):917-921. 200490) Grushko TA, Dignam JJ, Das S, Blackwood AM, Perou CM, Ridderstrale KK, Anderson KN, Wei MJ, Adams AJ, Hagos FG, Sveen L, Lynch HT, Weber BL, Olopade OI. MYC is amplified in BRCA1-associated breast cancers. Clin Cancer Res. 2004 Jan 15;10(2):499-507.91) Olopade OI, Wei M. 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(-)-Epigallocatechin-3-gallate ameliorates learning and memory impairments by attenuating peroxidation in APP/PS1 transgenic mice. Mol Neurodegener. 2012 Feb 7;7 Suppl 1:S29.96) Wang S, Liu M, Zhang Z, Yao W, Tang Q, Wei M*. EGCG and nimodipine improve the symptoms of AD by inhibiting [Ca2+]i in hippocampal neurons of APP/PS1 transgenic mice. Mol Neurodegener. 2012 Feb 7;7 Suppl 1:S30.97) Ren J, Wei MJ*, Zhao L, Wang L, Ma WF, Sun ML.Correlation analysis of BRCA1 and related genes expression and pathological parameters in sporadic breast carcinoma. Journal of Pharmacological Sciences, 2009,109(1): 268.98) Wei MJ*, Ren J. The hypermethylation of BRCA1 promoter related to sporadic breast carcinomas genesis in Chinese women. Journal of Pharmacological Sciences,2009,109(1): 268.99) Zhao L, Wang L, Ren J, Jin F, Wen XY, He M, Wei MJ*. Methylation and inactivation of estrogen receptor α (ERα) promoter in Chinese women with sporadic breast cancer. 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Journal of Pharmacological Sciences, 2009, 109(1):206.主编教材、专著11部1) 《药理学》(第1版),全国高等医学院校药学类专业“十三五”规划教材,主编,中国医药科技出版社,2016年。2) 《药理学实验指导》(第1版),主编,中国医药科技出版社,2016年。3) 《药理学》电子书,第八版全国统编教材,人民卫生出版社,魏敏杰(主编),2015年编写。4) 《临床药理学》(第2版),“十二五”普通高等教育本科国家级规划教材、卫生部“十二五”规划教材、全国高等医学教材建设研究会“十二五”规划教材,主编,人民卫生出版社,2015-03-015) 《药理学》(第2版),成人高等教育专业教材,主编,上海科学技术出版社,2016-126) 《临床药物代谢动力学(药学专业)》(第2版),成人高等教育专业教材,主编,上海科学技术出版社,2016-117) 《临床药物代谢动力学(药学专业)》,成人高等教育专业教材,主编,上海科学技术出版社,2011-10-018) 《药事管理学(药学专业)》,成人高等教育专业教材,主编,上海科学技术出版社,2011-08-019) 《药理学》,主编,上海出版社,2010年10) 《药理学(护理专业)》,成人高等教育专业教材,主编,上海科学技术出版社,2010-08-0111) 《注射药联合应用手册》,主编,人民军医出版社,2010-03-01兼任中国药理学会常务理事及中国药理学会化疗药理专业委员会副主任等多项学术兼职,国家新药评审专家。主办第一届、第三届两岸三地国际药理学术会议大会、承办2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议、承办2016年“中国药理学会第十三届全国化疗药理学术研讨会”。 相关热点
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