个人简历

刘万洋，教授，硕士生导师，营养与食品卫生学教研室。
教育经历
1993-1998年：中国医科大学 预防医学 本科
2002-2005年：中国医科大学 劳动卫生与环境卫生学 硕士
2006-2010年：京都大学 环境卫生学 博士（日本文部省奖学金资助）
工作经历（包括博士后及出国进修经历）
1998-2007年：辽宁省疾病预防控制中心 地方病防治所 医师/主治医师
2010-2013年：京都大学 医学研究科 环境卫生学教研室 博士后（日本学术振兴会外国人特别研究员奖学金资助）
2013-2014年：中国医科大学 公共卫生学院 营养与食品卫生学教研室 讲师
2014-2019年：中国医科大学 公共卫生学院 营养与食品卫生学教研室 副教授
2017-2018年：京都大学 环境卫生学 访问学者（国家留学基金-辽宁省地方合作项目资助）
2019-至 今：中国医科大学 公共卫生学院 营养与食品卫生学教研室 教授
主持课题情况
1. 国家自然科学基金：烟雾病和颅内动脉狭窄闭塞患者致病基因的遗传流行病学研究。2016-2019；68.4万元。
2. 辽宁省省级大学生创新创业项目创新训练甲类：中国汉族烟雾病主要致病基因鉴定。2016-2017；0.5万元。
3. 辽宁省教育厅科学研究一般项目：烟雾病和颅内动脉狭窄闭塞致病基因鉴定。2015-2018；6万元。
4. 日本学术振兴会外国人特别研究员科研奖励基金：烟雾病发病机制的研究。2010-2012年；210万日元。
5. 国家自然科学基金：脑发育关键期碘缺乏损伤海马学习记忆的机制。2006-2008；23万元。
研究生培养情况
硕士招生：2015年开始，共招收15人，4人已毕业（包括1名中国政府奖学金资助国际生）。
获得奖励及荣誉称号情况
2015年：中国医科大学公共卫生学院首届科研墙报比赛一等奖
2012年：京都大学医学研究科G-COE项目国际实习奖
2011年：第81回日本卫生学会学术总会优秀摘要奖
获得科学技术奖情况
1. 辽宁省科技进步二等奖：碘缺乏对学龄儿童智力损伤的调查及致脑发育障碍机制的研究。2011年；第四完成人。
2. 中华预防医学会科学技术奖三等奖：碘缺乏对学龄儿童智力损伤的调查及致脑发育障碍机制的研究。2011年；第四完成人。
3. 辽宁省科技进步三等奖：碘缺乏致亚临床损伤的流行病学调查及致海马神经发育损害的研究。2005年；第七完成人。

研究领域

遗传、营养与慢性病、碘营养与脑神经发育、持久性有机污染物监测与评价。""

近期论文

1. Wang X, Wang Y, Nie F, Li Q, Zhang K, Liu M, Yang L, Zhang Q, Liu S, Zeng F, Shang M, Liang M, Yang Y, Liu X, Liu W*. The association of genetic variants with moyamoya disease in 13,000 individuals: A meta-analysis. Stroke. 2020 (Accepted) (IF: 6.058).
2. Wang Y#, Zhang Z#, Wei L# (#共同第一作者), Zhang Q, Zou Z, Yang L, Li D, Shang M, Han C, Mambiya M, Bao X, Li Q, Hao F, Zhang K, Wang H, Liu S, Liu M, Zeng F, Nie F, Wang K*, Liu W*, Duan L*. Predictive role of heterozygous p.R4810K of RNF213 in phenotype of Chinese moyamoya disease. Neurology. 2020,94(7):e678-e686. (IF= 8.689)
3. Liu M, Shang M, Wang Y, Li Q, Liu X, Yang L, Zhang Q, Zhang K, Liu S, Nie F, Zeng F, Wen Y, Liu W*. Effects of TNF-α-308G/A Polymorphism on the Risk of Diabetic Nephropathy and Diabetic Retinopathy: An Updated Meta-Analysis. Horm Metab Res. 2020; 52: 1–8. (IF= 2.423).
4. Mambiya M#, Shang M# (#equal contribution), Wang Y, Li Q, Liu S, Yang L, Zhang Q, Zhang K, Liu M, Nie F, Zeng F, Liu W*. The Play of Genes and Non-Genetic Factors on Types 2 Diabetes. Front Public Health. 2019 Nov 19;7:349. doi: 10.3389/fpubh.2019.00349. eCollection 2019. (IF= 2.031).
5. Nie F, Yu M, Zhang K, Yang L, Zhang Q, Liu S, Liu M, Shang M, Zeng F, Liu W*. Association of MTHFR gene polymorphisms with pancreatic cancer: meta-analysis of 17 case-control studies. Int J Clin Oncol. 2020,25(2),312-321. (IF= 2.503).
6. Liu S, Liu M# (#equal contribution), Li Q, Liu X, Wang Y, Mambiya M, Zhang K, Yang L, Zhang Q, Shang M, Zeng F, Nie F, Liu W*. Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure. Biosci Rep. 2019 Dec 20;39(12). pii: BSR20191454. doi: 10.1042/BSR20191454. (IF= 2.535).
7. Nie F, Yu M, Liu M, Shang M, Zeng F, Liu W*. NINJ2 gene polymorphisms and susceptibility to ischemic stroke: an updated meta-analysis. Curr Neurovasc Res. 2019 Jun 18. doi: 10.2174/1567202616666190618125241. (IF= 1.811, Times Cited: 0)
8. Liu M#, Liu S# (#共同第一作者) , Shang M, Liu X, Wang Y, Li Q, Mambiya M, Yang L, Zhang Q, Zhang K, Nie F, Zeng F, Liu W*. Association between ADIPOQ G276T and C11377G polymorphisms and the risk of non-alcoholic fatty liver disease: An updated meta-analysis. Mol Genet Genomic Med. 2019 Mar 5:e624. (IF= 2.448, Times Cited: 0)
9. Wang Y#, Mambiya M#, Li Q, Yang L, Jia H, Han Y, Liu W*. RNF213 p.R4810K polymorphism and the risk of Moyamoya Disease, Intracranial Major Artery Stenosis/Occlusion and Quasi-Moyamoya Disease: a meta-analysis. J Stroke Cerebrovasc Dis. 2018,27(8): 2259-2270. (IF= 1.646, Times Cited: 3)
10. Wang Y, Li Q, Mambiya M, Zhang K, Yang L, Zhang Q, Liu S, Liu M, Yin J, Liu W*. A Meta-Analysis of the Association between MicroRNA-196a2 and Risk of Ischemic Stroke and Coronary Artery Disease in Asian population. J Stroke Cerebrovasc Dis. 2018,27(11):3008-3019. (IF= 1.646, Times Cited: 2)
11. Kobayashi H, Kabata R, Kinoshita H*, Morimoto T, Ono K, Takeda M, Choi J, Okuda H, Liu W, Harada KH, Kimura T, Youssefian S, Koizumi A. Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice. Pulm Circ. 2018 Jul-Sep;8(3):2045894018778155. (IF= 2.075, Times Cited: 2)
12. Cao Y, Harada KH, Liu W, Yan J, Zhao C, Niisoe T, Adachi A, Fujii Y, Nouda C, Takasuga T, Koizumi A*. Short-chain chlorinated paraffins in cooking oil and related products from China. Chemosphere. 2015;138:104-111. (IF= 3.340, Times Cited: 27)
13. Nanayakkara S, Senevirathna ST, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne ED, Yan J, Hitomi T, Muso E, Komiya T, Harada KH, Liu W, Kobayashi H, Okuda H, Sawatari H, Matsuda F, Yamada R, Watanabe T, Miyataka H, Himeno S, Koizumi A*. An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. J Occup Health. 2014;56(1):28-38. (IF= 1.096, Times Cited: 36)
14. Liu W, Senevirathna ST, Hitomi T, Kobayashi H, Roder C, Herzig R, Kraemer M, Voormolen MH, Cahová P, Krischek B*, Koizumi A*. Genomewide association study identifies no major founder variant in Caucasian moyamoya disease. J Genet. 2013;92(3):605-609. (IF= 1.013, Times Cited: 27)
15. Liu W, Yin T, Okuda H, Harada KH, Li Y, Xu B, Yang J, Wang H, Fan X, Koizumi A, Miyata T*. Protein S K196E mutation, a genetic risk factor for venous thromboembolism, is limited to Japanese. Thromb Res. 2013; 132(2):314-315. (IF= 2.427, Times Cited: 12)
16. Liu W, Takahashi S, Sakuramachi Y, Harada KH, Koizumi A*. Polyfluorinated telomers in indoor air of Japanese houses. Chemosphere 2013;90(5):1672-1677. (IF= 3.499, Times Cited: 15)
17. Liu W, Tanabe M, Harada KH, Koizumi A*. Levels of urinary isoflavones and lignan polyphenols in Japanese women. Environ Health Prev Med. 2013;18(5):394-400. (Times Cited: 9)
18. Mineharu Y*, Takagi Y, Takahashi JC, Hashikata H, Liu W, Hitomi T, Kobayashi H, Koizumi A, Miyamoto S. Rapid progression of unilateral moyamoya disease in a patient with a family history and an RNF213 risk variant. Cerebrovasc Dis. 2013;36(2):155-157. (IF= 3.698, Times Cited: 22)
19. Kobayashi H, Yamazaki S, Takashima S, Liu W, Okuda H, Yan J, Fujii Y, Hitomi T, Harada KH, Habu T, Koizumi A*. Ablation of Rnf213 retards progression of diabetes in the Akita mouse. Biochem Biophys Res Commun. 2013;432(3):519-525. (IF= 2.281, Times Cited: 27)
20. Yan J, Takahashi T, Ohura T, Adachi H, Takahashi I, Ogawa E, Okuda H, Kobayashi H, Hitomi T, Liu W, Harada KH, Koizumi A*. Combined linkage analysis and exome sequencing identifies novel genes for familial goiter. J Hum Genet. 2013;58(6):366-377. (IF= 2.526, Times Cited: 13)
21. Liu W, Harada KH, Hitomi T, Kobayashi H, Koizumi A*. Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian populations. Neurol Med Chir (Tokyo). 2012;52(5):299-303. (IF= 0.493, Times Cited: 66)
22. Koizumi A*, Kobayashi H, Liu W, Fujii Y, Senevirathna STMLD, Nanayakkara S, Okuda H, Hitomi T, Harada KH, Takenaka K, Watanabe T, Shimbo S. P.R4810K, a Polymorphism of RNF213, the Susceptibility Gene for Moyamoya Disease, Is Associated with Blood Pressure. Environ Health Prev Med. 2012; 18(2): 121-129. (Times Cited: 36)
23. Liu W, Chen S, Harada KH, Koizumi A*. Analysis of perfluoroalkyl carboxylates in vacuum cleaner dust samples in Japan. Chemosphere 2011;85(11):1734-1741. (IF= 3.206, Times Cited: 15)
24. Liu W#, Morito D#, Takashima S#, Mineharu Y#, Kobayashi H#, Hitomi T#, Hashikata H#, Matsuura N# (#共同第一作者), Yamazaki S, Toyoda A, Kikuta K, Takagi Y, Harada KH, Fujiyama A, Herzig R, Krischek B, Zou L, Kim JE, Kitakaze M, Miyamoto S, Nagata K, Hashimoto N*, Koizumi A*. Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One. 2011;6(7):e22542. (IF= 4.092, Times Cited: 263)
25. Dong J#, Liu W# (#共同第一作者), Wang Y, Hou Y, Xu H, Gong J, Xi Q, Chen J*. Developmental iodine deficiency and hypothyroidism impair spatial memory in adolescent rat hippocampus: involvement of CaMKII, Calmodulin and Calcineurin. Neurotox Res. 2011;19(1):81-93. (IF= 3.514, Times Cited: 11)
26. Kobayashi H#, Abe K#, Matsuura T# (#共同第一作者), Ikeda Y, Hitomi T, Akechi Y, Habu T, Liu W, Okuda H, Koizumi A*. Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement. Am J Hum Genet. 2011;89(1):121-130. (IF= 10.603, Times Cited: 140)
27. Mineharu Y, Liu W, Hashikata H, Inoue K, Matsuura N, Kobayashi H, Kikuta K, Takagi Y, Hitomi T, Hashimoto N, Miyamoto S, Koizumi A*. A polymorphism in Raptor is associated with moyamoya disease in the East Asian populations. Stroke 2011;42(3): E142-E142. Meeting abstract (IF= 5.729, Times Cited: 0)
28. Liu W, Dong J, Wang Y, Xi Q, Chen J*. Developmental iodine deficiency and hypothyroidism impaired in vivo synaptic plasticity and altered PKC activity and GAP-43 expression in rat hippocampus. Nutr Neurosci. 2010;13(5):213-222. (IF= 1.301, Times Cited: 1)
29. Liu W#, Hashikata H#, Inoue K# (#共同第一作者), Matsuura N, Mineharu Y, Kobayashi H, Kikuta KI, Takagi Y, Hitomi T, Krischek B, Zou LP, Fang F, Herzig R, Kim JE, Kang HS, Oh CW, Tregouet DA, Hashimoto N, Koizumi A*. A rare Asian founder polymorphism of Raptor may explain the high prevalence of Moyamoya disease among East Asians and its low prevalence among Caucasians. Environ Health Prev Med. 2010;15(2): 94-104. (Times Cited: 38)
30. Hashikata H#, Liu W# (#共同第一作者), Inoue K, Mineharu Y, Yamada S, Nanayakkara S, Matsuura N, Hitomi T, Takagi Y, Hashimoto N, Miyamoto S, Koizumi A*. Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients. Stroke. 2010 ;41(6):1138-1144. (IF= 5.756, Times Cited: 29)
31. Gong J, Dong J, Wang Y, Xu H, Wei W, Zhong J, Liu W, Xi Q, Chen J*. Developmental iodine deficiency and hypothyroidism impair neural development, up-regulate Caveolin-1, and down-regulate Synaptophysin in rat hippocampus. J Neuroendocrinol. 2010;22:129-139. (IF= 4.650, Times Cited: 25)
32. Dong J, Liu W, Wang Y, Xi Q, Chen J*. Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats. Int J Dev Neurosci. 2010;28(7):589-596. (IF= 1.938, Times Cited: 11)
33. Gong J, Liu W, Dong J, Wang Y, Xu H, Wei W, Zhong J, Xi Q, Chen J*. Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of Doublecortin and NCAM-180. BMC Neurosci. 2010;11:50. (IF= 3.091, Times Cited: 38)
34. Dong J, Liu W, Wang Y, Hou Y, Xi Q, Chen J*. Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats. BMC Neurosci. 2009;10:149. doi:10.1186/1471-2202-10-149. (IF= 2.744, Times Cited: 17)
35. Mineharu Y#, Liu W# (#共同第一作者), Inoue K, Matsuura N, Inoue S, Takenaka K, Ikeda H, Houkin K, Takagi Y, Kikuta K, Nozaki K, Hashimoto N, Koizumi A*. Autosomal dominant moyamoya disease maps to chromosome 17q25.3. Neurology. 2008;70 (24 Pt 2):2357-2363. (IF= 7.043, Times Cited: 110)
36. Tang Z, Liu W, Yin H, Wang P, Dong J, Wang Y, Chen J*. Investigation of intelligence quotient and psychomotor development in schoolchildren in areas with different degrees of iodine deficiency. Asia Pac J Clin Nutr. 2007;16(4):731-737. (IF= 1.180, Times Cited: 24)
37. Inoue S, Liu W, Inoue K, Mineharu Y, Takenaka K, Yamakawa H, Abe M, Jafar JJ, Herzig R, Koizumi A*. Combination of linkage and association studies for brain arteriovenous malformation. Stroke. 2007;38 (4):1368-1370. (IF= 6.296, Times Cited: 10)
38. Dong J, Yin H, Liu W, Wang P, Jiang Y, Chen J*. Congenital iodine deficiency and hypothyroidism impair LTP and decrease C-fos and C-jun expression in rat hippocampus. Neurotoxicology. 2005;26:417-426. (IF= 2.576, Times Cited: 85)
39. Chen Y, Chen J*, Dong J, Liu W. Antifibrotic effect of interferon gamma in silicosis model of rat. Toxicol Lett. 2005;155:353-360. (IF= 2.430, Times Cited: 39)
教材/著作：
2017年：《Moyamoya Disease Explored Through RNF213》 Springer出版社 编委
2020.1-2025.1    辽宁省营养学会第七届理事会 理事
2018.5-2021.5    辽宁省环境科学学会环境与健康分会第一届理事会 理事
2018.10-2022.10  辽宁省营养学会老年营养专业委员会 委员
2018.10-2022.10  辽宁省营养学会营养与烹饪专业委员会 委员
2018.12-2022.12  辽宁省营养学会第二届公共营养专业委员会 委员
2017.4-2021.3    辽宁省预防医学会食品安全与营养专业委员会 委员
2014.12-2017.3   辽宁省预防医学会食品卫生专业委员会 委员
2014.7-至今      中国营养学会 会员
2014.7-至今      中国毒理学会 会员
2006.2-2013.3    日本卫生学会 会员