个人简历

董静，教授、硕士生导师，尘肺研究室，辽宁省“百千万”人才工程万人层次人选。
教育经历
1997-2002年：中国医科大学 预防医学 本科
2002-2005年：中国医科大学 劳动卫生与环境卫生学 硕士
2005-2008年：中国医科大学 劳动卫生与环境卫生学 博士
工作经历（包括博士后及出国进修经历）
2008-2010年：中国医科大学 公共卫生学院 尘肺研究室 讲师
2010-2015年：中国医科大学 公共卫生学院 尘肺研究室 副教授
2015-至今： 中国医科大学 公共卫生学院 尘肺研究室 教授
主持课题情况
1. 辽宁省自然科学基金：母体邻苯二甲酸二(2-乙基)己酯暴露致后代神经行为和发育损伤的跨代遗传效应及机制研究。2019-2022年；5万元。
2. 国家自然科学基金项目：妊娠期和哺乳期母体邻苯二甲酸酯暴露对子代神经发育的影响及机制研究。2015-2018年；85万元。
3. 辽宁省高等学校优秀人才支持计划：环境内分泌干扰物与脑神经发育。2015-2018年；12万元。
4. 国家自然科学基金：不同程度碘营养不足对大鼠子代海马神经发育的影响及其机制研究。2012-2014年；20万元。
5. 高等学校博士学科点专项科研基金（新教师类）：碘缺乏影响仔鼠海马突触可塑性及钙离子内流的机制。2010-2012年；3.6万元。
获得科学技术奖情况
1. 辽宁省科技进步奖三等奖：脑发育关键期不同摄碘量对脑神经发育及智力影响的应用基础研究。2016年；第二完成人。
2. 辽宁省科技进步奖二等奖、中华预防医学会科学技术奖三等奖：碘缺乏对学龄儿童智力损伤的调查及致脑发育障碍机制的研究。2011年；第二完成人。
3. 教育部科技进步奖二等奖、辽宁省科技进步奖二等奖：生产性粉尘所致肺疾病发病机制、规律及其防制研究。2008年；第八完成人。
研究生培养情况
硕士招生：2012年开始，共招收17人，已毕业7人

研究领域

职业与环境神经毒理学""

近期论文

1. Dong J, Cong Z (joint first author), You M, Fu Y, Wang Y, Wang Y, Fu H, Wei L, Chen J. Effects of Perinatal Di (2-ethylhexyl) phthalate Exposure on Thyroid Function in Rat Offspring. Environmental Toxicology and Pharmacology，2019；67:53-60.
2. Fu Y, Dong J (joint first author), You M, Cong Z, Wei L, Fu H, Wang Y, Wang Y, Chen J*. Maternal di-(2-ethylhexyl) phthalate exposure inhibits cerebellar granule precursor cell proliferation via down-regulating the Shh signaling pathway in male offspring. Chemosphere, 2018; 215:313-322.
3. You M, Dong J (joint first author), Fu Y, Cong Z, Fu H, Wei L, Wang Y, Wang Y, Chen J*. Exposure to Di-(2-ethylhexyl) Phthalate during Perinatal Period Gender-Specifically Impairs the Dendritic Growth of Pyramidal Neurons in Rat Offspring. Frontiers in Neuroscience, 2018; 12: 444.
4. Fu Y, Dong J (joint first author), Wang J, You M, Wei L, Fu H, Wang Y, Chen J. Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway. Experimental Neurobiology. 2018; 27(6): 472-488.
5. Dong J, Song H, Wang Y, Li M, Yu Y, Wang Y, Chen J*. Maternal Different Degrees of Iodine Deficiency during Pregnant and Lactation Impair the Development of Cerebellar Pinceau in Offspring. Frontiers in Neuroscience, 2017; 11: 298.
6. Yu Y, Dong J (joint first author), Wang Y, Wang Y, Min H, Shan Z, Teng W, Chen J*. Effects of Maternal Marginal Iodine Deficiency on Interactions between Cerebellar Cerebellar Bergmann Glia Cells and Purkinje Cells in Rat Offspring. Biomed Environ Sci. 2017; 30(12):932-937.
7. Dong J, Lei X, Wang Y, Wang Y, Song H, Li M, Min H, Yu Y, Xi Q, Teng W, Chen J*. Different Degrees of Iodine Deficiency Inhibit Differentiation of Cerebellar Granular Cells in Rat Offspring, via BMP-Smad1/5/8 Signaling. Mol. Neurobio. 2016; 53(7): 4606-4617.
8. Min H, Dong J (joint first author), Wang Y, Wang Y, Teng W, Xi Q, Chen J* Maternal Hypothyroxinemia-Induced Neurodevelopmental Impairments in the Progeny. Mol. Neurobio. 2016; 53(3): 1613-1624.
9. Dong J, Wang Y, Wang Y, Wei W, Min H, Song B, Xi Q, Teng W, Chen J*. Iodine deficiency increases apoptosis and decreases synaptotagmin-1 and PSD-95 in rat hippocampus. Nutr Neurosci. 2013; 16(3):135-141.
10. Dong J, Liu W, Wang Y, Hou Y, Xu H, Gong J, Xi Q, Chen J*. Developmental iodine deficiency and hypothyroidism impair spatial memory in adolescent rat hippocampus: involvement of CaMKII, Calmodulin and Calcineurin. Neurotox Res. 2011; 19: 81-93.
11. Dong J, Liu W, Wang Y, Xi Q, Chen J*. Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats. Int J Dev Neurosci. 2010, 28: 589-596.
12. Dong J, Liu W, Wang Y, Hou Y, Xi Q, Chen J*. Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats. BMC Neurosci. 2009; 10: 149.
13. Dong J, Yin H, Liu W, Wang P, Jiang Y, Chen J*. Congenital iodine deficiency and hypothyroidism impair LTP and decrease c-fos and c-jun expression in rat hippocampus. Neurotoxicology, 2005; 26: 417-426.
14. Min H, Dong J, Wang Y, Wang Y, Yu Y, Shan Z, Xi Q, Teng W, Chen J*. Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton. Molecular Neurobiology, 2017; 54(1):437-449.
15. Yu Y, Dong J, Wang Y, Wang Y, Min H, Shan Z, Teng W, Chen J*. Maternal marginal iodine deficiency limits dendritic growth of cerebellar purkinje cells in rat offspring by NF-κB signaling and MAP1B. Environ Toxicol, 2017; 32(4):1241-1251.
16. Wang Y, Dong J, Wang Y, Wei W, Song B, Shan Z, Teng W, Chen J*. Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel fiber–Purkinje cell Synapses in Rat Offspring by Downregulation of Neurexin1/Cbln1/GluD2 Tripartite Complex. Biol Trace Elem Res, 2016; 173(2): 465-474.
17. Wang B, Liu F, Dong J, You M, Fu Y, Li C, Lu Y, Chen J*. Maternal exposure to environmental DEHP exacerbated OVA-induced asthmatic responses in rat offspring. Science of the Total Environment，2018; 615:253-261.
18. Min H, Wang Y, Dong J, Wang Y, Yu Y, Shan Z, Xi Q, Teng W, Chen J*. Effects of Maternal Marginal Iodine Deficiency on Dendritic Morphology in the Hippocampal CA1 Pyramidal Neurons in Rat Offspring. Neuromolecular Med, 2016; 18(2): 203-215.
19. Wei W, Wang Y, Dong J, Wang Y, Min H, Song B, Shan Z, Teng W, Xi Q, Chen J*. Hypothyroxinemia Induced by Maternal Mild Iodine Deficiency Impairs Hippocampal Myelinated Growth in Lactational Rats. Environmental Toxicology, 2015, 30(11):1264-1274
20. Wang Y, Wang Y, Dong J, Wei W, Song B, Min H, Yu Y, Lei X, Zhao M, Teng W*, Chen J*. Developmental hypothyroxinemia and hypothyroidism reduce proliferation of cerebellar granule neuron precursors in rat offspring by downregulation of the sonic hedgehog signaling pathway. Mol Neurobiol. 2014; 49(3): 1143-1152.
21. Wang Y, Wang Y, Dong J, Wei W, Song B, Min H, Teng W*, Chen J *. Developmental hypothyroxinaemia and hypothyroidism limit dendritic growth of cerebellar Purkinje cells in rat offspring: involvement of microtubule-associated protein 2 (MAP2) and stathmin. Neuropathol Appl Neurobiol. 2014; 40(4): 398-415.
22. Wei W, Wang Y, Dong J, Wang Y, Min H, Song B, Shan Z, Teng W, Xi Q, Chen J*. Hypothyroxinemia induced by mild iodine deficiency deregulats thyroid proteins during gestation and lactation in dams. Int J Environ Res Public Health. 2013; 10(8): 3233-3245.
教材：
2015年：全国高等学校长学制临床医学专业规划教材《预防医学学习指导与习题集》 人民卫生出版社 编委