个人简历

教育背景\r
2006.09~2009.07 中科学院上海营养与健康研究所 生化与分子生物学 博士\r
2003.09~2006.07 南京大学 植物学 硕士\r
1996.09~2003.06 聊城大学 生命科学 学士\r
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工作经历 \r
2022.01~至今 中国海洋大学 医药学院 教授\r
2016.01~2021.12 中国海洋大学 医药学院 副教授\r
2009.07~2015.12 中国海洋大学 医药学院 讲师

研究领域

""(1)慢性代谢性疾病先导药物的发现、结构优化与应用转化\r
(2) 基于线粒体代谢通路的中药及海洋药物新作用模式、作用靶点及调控网络和分子机制研究""""

近期论文

He, Meijia; Hao, Jiejie*; Feng, Changning; Yang, Yajing; Shao, Zhuling; Wang, Lei; Mao, Wenjun*. Anti-diabetic activities of a sulfated galactoarabinan with unique structural characteristics from Cladophora oligoclada (Chlorophyta). CARBOHYDRATE POLYMERS (IF 9.3) 278: 118933 Feb 2022.\r
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Li, Dan; Zhang, Shuai; Yang, Cheng; Li, Quancai; Wang, Shixin; Xu, Ximng; Hao, Jiejie*; Li, Chunxia*. A Novel PTP1B Inhibitor-Phosphate of Polymannuronic Acid Ameliorates Insulin Resistance by Regulating IRS-1/Akt Signaling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (IF 5.9) 22: 12693 NOV 2021.\r
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Wang, Xueliang; Jiang, Hao; Zhang, Ning; Cai, Chao; Li, Guoyun; Hao, Jiejie*; Yu, Guangli*. Anti-diabetic activities of agaropectin-derived oligosaccharides from Gloiopeltis furcata via regulation of mitochondrial function. CARBOHYDRATE POLYMERS (IF 9.3) 229: 115482 FEB 2020.\r
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Li, Qiong; Bai, Donghui; Qin, Ling; Shao, Meng; Zhang, Shuai; Yan, Chengxiu; Yu, Guangli*; Hao, Jiejie*. Protective effect of D-tetramannuronic acid tetrasodium salt on UVA-induced photo-aging in HaCaT cells. BIOMEDICINE & PHARMACOTHERAPY (IF 6.5) 126: 110094 JUN 2020.\r
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Liu, Xi; Li, Qiong; Cheng, Xiaolei; Liu, Zhichun; Zhao, Xiaoliang; Zhang, Shuai; Yu, Guangli; Zhao, Xia*; Hao, Jiejie*. Oligomannuronate prevents mitochondrial dysfunction induced by IAPP in RINm5F islet cells by inhibition of JNK activation and cell apoptosis. CHINESE MEDICINE (IF 5.5) 15: 1 MAR 24 2020.\r
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Shan, Xindi; Wang, Xueliang; Jiang, Hao; Cai, Chao; Hao, Jiejie*; Yu, Guangli*. Fucoidan fromAscophyllumnodosumSuppresses Postprandial Hyperglycemia by Inhibiting Na+/Glucose Cotransporter 1 Activity. MARINE DRUGS (IF 5.1) 18: 9 SEP 2020.\r
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Li, Qiong; Bai, Donghui; Qin, Ling; Shao, Meng; Liu, Xi; Zhang, Shuai; Yan, Chengxiu; Yu, Guangli*; Hao, Jiejie*. Protective Effect of L-Hexaguluroic Acid Hexasodium Salt on UVA-Induced Photo-Aging in HaCaT Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (IF 5.9) 21: 4 FEB 2020.\r
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Wang, Xueliang; Shan, Xindi; Dun, Yunlou; Cai, Chao; Hao, Jiejie*; Li, Guoyun; Cui, Kaiyun; Yu, Guangli*. Anti-Metabolic Syndrome Effects of Fucoidan from Fucus vesiculosus via Reactive Oxygen Species-Mediated Regulation of JNK, Akt, and AMPK Signaling. MOLECULES (IF 4.3) 24 :18 SEP 2019.\r
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Wang, Xueliang; Wang, Xin; Jiang, Hao; Cai, Chao; Li, Guoyun; Hao, Jiejie*; Yu, Guangli. Marine polysaccharides attenuate metabolic syndrome by fermentation products and altering gut microbiota: An overview. CARBOHYDRATE POLYMERS (IF 6.0) 195: 601-612 SEP 2018.\r
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Xin, Meng; Sun, Yang; Chen, Haijiao; Li, Quancai; Dun, Yunlou; Guan, Huashi; Hao, Jiejie*; Li, Chunxia*. Propylene glycol guluronate sulfate (PGGS) reduces lipid accumulation via AMP-activated kinase activation in palmitate-induced HepG2 cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (IF 5.1) 114: ‏26-34 JUL 2018.\r
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Yang, Yi; Zhao, Xiaoliang; Li, Jia; Jiang, Hao; Shan, Xindi; Wang, Ya; Ma, Wenbang; Hao, Jiejie*; Yu, Guangli*. A beta-glucan from Durvillaea Antarctica has immunomodulatory effects on RAW264.7 macrophages via toll-like receptor 4. CARBOHYDRATE POLYMERS (IF 6.0) 191: 255-265 JUL 1 2018.\r
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Liu, Xue ; Hao, Jiejie* ; He, Xiaoxi ; Wang, Shuyao; Cao, Sujian; Qin, Ling ; Mao, Wenjun*. A rhamnan-type sulfated polysaccharide with novel structure from Monostroma angicava Kjellm (Chloroph yta) and its bioactivity. CARBOHYDRATE POLYMERS (IF 5.1) 173: 732-748 OCT 2017