个人简历

Education Experience 2009-2016 Postdoctoral Genetics Harvard Medical School, U.S.A 2003-2009 Ph. D. Molecular Genetics Georgia Institude of Technology, U.S.A 1997-1999 M.S. Microbiology Hanyang University, S. Korea Professional Experience 2009-2016 Research fellow Harvard Medical School, U.S.A 2004-2009 Research and Teaching assistant Georgia Institute of Technology, U.S.A 1999-2003 Research scientist Hanyang University Medical School, S.Korea 1997-1998 Research and Teaching assistant Hanyang University, S.Korea

研究领域

We are interested in understanding the DNA repair mechanism in the germline. Especially, we have focused on investigating the epigenetic regulation of DNA damage response and repair. We use a microscopic size nematode C. elegans and mammalian cells to study epigenetic control of DNA repair mechanism. 1. The role of conserved Epigenetic regulators in DNA repair and damage response. 2.The role of novel and conserved gene of DNA repair and damage response.    

近期论文

2018 Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Kim, H. M.; Beese-Sims, S. E.; Colaiácovo, M. P. Genetics 209 2018 Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis Ferrandiz, N.; Barroso, C.; Telecan, O.; et al. Nat Commun 9 2017 Wrestling with Chromosomes:The Roles of SUMO during meiosis Amanda C.Nottke, Hyun-Min Kim and Monica P. Colaiacovo 2016 N-terminal acetylation promotes synaptonemal complex assembly in C. elegans Gao, J.; Barroso, C.; Zhang, P.; et al. Genes Dev 30 2015 DNA Damage Sensitivity Assays in Caenorhabditis elegans Kim, H. M.; Colaiacovo, M. P. Bio-Protocol Bio-protocol 5(11): e1487. 2015 Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual Marker Selection Cassettes Norris, A. D.; Kim, H. M.; Colaiacovo, M. P.; et al. Genetics 2015 NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis Gao, J.; Kim, H. M.; Elia, A. E.; et al. PLoS Genet 11 2015 New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans Kim, H. M.; Colaiacovo, M. P. Genetics 2014 A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans Kim, H.; Ishidate, T.; Ghanta, K. S.; et al. Genetics 197 2014 REST and stress resistance in ageing and Alzheimer’s disease Lu, T.; Aron, L.; Zullo, J.; et al. Nature 507 2014 ZTF-8 Interacts with the 9-1-1 Complex and Is Required for DNA Damage Response and Double-Strand Break Repair in the C. elegans Germline Kim, H. M.; Colaiacovo, M. P. PLoS Genet 10 2013 ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans Sengupta, M. S.; Low, W. Y.; Patterson, J. R.; et al. J Cell Sci 126 2013 Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis Saito, T. T.; Lui, D. Y.; Kim, H. M.; et al. PLoS Genet 9 2012 Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools Waisertreiger, I. S.; Liston, V. G.; Menezes, M. R.; et al. Environ Mol Mutagen 53 2012 Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells Oh, B.; Kim, T. Y.; Min, H. J.; et al. Anticancer Drugs 24 2011 Friedreich’s ataxia (GAA)n*(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae Tang, W.; Dominska, M.; Greenwell, P. W.; et al. PLoS Genet 7 2008 Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair Kim, H. M.; Narayanan, V.; Mieczkowski, P. A.; et al. EMBO J 27 2006 The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks Narayanan, V.; Mieczkowski, P. A.; Kim, H. M.; et al. Cell 125 2001 Sequence analysis and insertional inactivation of a gene encoding Moraxella sp. CK-1 cell wall hydrolase Kim, H. M.; Ohn, T. B.; Min, B. R.; et al. Antonie Van Leeuwenhoek 79