个人简历

学科方向\t 药物分子生物分析
孔德明，1998年毕业于南开大学化学系化学专业，获学士学位，同年保送攻读博士研究生。2003年毕业，获南开大学分析化学博士学位。2003年7月留校任教，2004年12月由讲师晋升为副教授，2009年12月晋升为教授。2014年1月~7月赴美国肯特州立大学进行了为期半年的高级访问学者研究工作。作为第二完成人获2008年度天津市自然科学二等奖1项；获2010年度中国化学会青年化学奖；入选2010年度教育部新世纪优秀人才支持计划；2014年获国家自然科学基金委优秀青年科学基金的资助。
孔德明实验室的主要研究方向是生物分析化学。目前主要从事两方面的研究工作：生物传感器的设计及分子影像探针的研究。共主持国家自然科学基金项目5项，天津市基金项目2项，参与973项目2项。目前，已有70余篇研究论文在“Nucleic Acids Research”、“Analytical Chemistry”、“Chemistry - A European Journal”、“Chemical Communications”、 “Biosensor & Bioelectronics”、“Scientific Reports”等国内外重要期刊上发表。

研究领域

""生物分析""""

近期论文

Gui-Mei Han, Zhen-Zhen Jia, Yan-Jun Zhu, Jia-Jia Jiao, De-Ming Kong*, Xi-Zeng Feng*, Biostable L?DNA-templated aptamer-silver nanoclusters for cell-type-specific imaging at physiological temperature. Analytical Chemistry, 2016, 88, 10800-10804.\r
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Yi-Chen Du, Li-Na Zhu, De-Ming Kong*, Label-free thioflavin T/G-quadruplex-based real-time strand displacement amplification for biosensing applications. Biosensors and Bioelectronics, 2016, 86, 811-817.\r
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Yi-Chen Du, Hong-Xin Jiang, Yan-Fang Huo, Gui-Mei Han, De-Ming Kong*, Optimization of strand displacement amplification-sensitized G-quadruplex DNAzyme-based sensing system and its application in activity detection of uracil-DNA glycosylase. Biosensors and Bioelectronics, 2016, 77, 971-977.\r
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Hong-Xin Jiang, Meng-Yao Zhao, Chen-Di Niu, De-Ming Kong*, Real-time monitoring of rolling circle amplification using aggregation-induced emission: applications in biological detection. Chemical Communications, 2015, 51, 16518-16521.\r
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Qi Zhang, Yan-Chen Liu, De-Ming Kong*, Dong-Sheng Guo*, Tetraphenylethene derivatives with different numbers of positively charged side arms have different multimeric G-quadruplex recognition specificity. Chemistry-A European Journal, 2015, 21, 13253-13260. \r
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Qi Zhang, Chan Song, Ting Zhao, Hai-Wei Fu, Hui-Zhen Wang, Yong-Jian Wang, De-Ming Kong*, Photoluminescent sensing for acidic amino acids based on the disruption of graphene quantum dots/europium ions aggregates. Biosensors and Bioelectronics, 2015, 65, 204-210. \r
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Chan Song, Guan-Yao Wang, De-Ming Kong*, A facile fluorescence method for versatile biomolecular detection based on pristine α-Fe2O3 nanoparticle-induced fluorescence quenching. Biosensors and Bioelectronics, 2015, 68, 239-244. \r
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Hong-Xin Jiang, Yunxi Cui, Ting Zhao, Hai-Wei Fu, Deepak Koirala, Jibin Abraham Punnoose, De-Ming Kong*, Hanbin Mao*, Divalent cations and molecular crowding buffers stabilize G-triplex at physiologically relevant temperatures. Scientific Reports, 2015, 5, 9255. \r
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Xiao-Xi Huang, Li-Na Zhu, Bin Wu, Yan-Fang Huo, Na-Na Duan, De-Ming Kong*, Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes. Nucleic Acids Research, 2014, 42, 8719-8731. \r
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Hong-Xin Jiang, De-Ming Kong*, Han-Xi Shen, Amplified detection of DNA ligase and polynucleotide kinase/phosphatase on the basis of enrichment of catalytic G-quadruplex DNAzyme by rolling circle amplification. Biosensors and Bioelectronics, 2014, 55, 133-138.