周国春
近期热点
资料介绍
个人简历
教育背景\r1997,9 - 2000,7 博士 中国科学院上海药物研究所\r1986,9 - 1989,6 硕士 兰州大学化学系\r1982,9 -1986,7 本科 南京大学 化学系\r\r工作经历\r2010,3-现在, 教授、课题负责人、博士生导师 南京工业大学药学院 研究方向:药物化学,化学生物学\r2005,3-2010,3, 研究员、课题组长 (PI)、博士生导师 中国科学院广州生物医药与健康研究院 研究方向:药物化学,化学生物学\r2002,8 – 2005,2 Research Associate 美国爱因斯坦医学院生物化学系 \r2001,2 – 2002,8 博士后 美国 麻省理工学院 (MIT) 癌症研究中心和约翰霍普金斯大学医学院分子药理系\r2000,8 - 2001,1 博士后 美国乔治城大学医学中心药物发现研究部\r1989,6 - 1997,8 助理工程师、工程师 江苏省农药研究所研究领域
""药物化学,化学生物学""""近期论文
Z Liu, W-K Law, D Wang, X Nie, D Sheng, S Song, K Guo, P Wei, P Ouyang, C-W Wong*, Guo-Chun Zhou (周国春)* “Synthesis and discovery of andrographolide derivatives as non-steroidal farnesoid X receptor (FXR) antagonists” RSC Adv., 2014, 4, 13533–13545 (*共同通讯作者)\r\rGuo-Chun Zhou (周国春)*, Fang Liu, Junting Wan, Jing Wang*, Decai Wang, Ping Wei, Pingkai Ouyang “Design, synthesis and evaluation of a cellular stable and detectable biotinylated fumagillin probe and investigation of cell permeability of fumagillin and its analogs to endothelial and cancer cells” Eur J Med Chem 2013, 70, 631-639. (共同通讯作者)\r\rGuo-Chun Zhou (周国春)*, Zhibing Weng, Xiaoxia Shao, Fang Liu, Xin Nie, Jinsong Liu, Decai Wang, Chunguang Wang, Kai Guo* “Discovery and SAR studies of methionine–proline anilides as dengue virus NS2B-NS3 protease inhibitors”, Bioorg Med Chem Lett 2013, 23, 6549–6554. (共同通讯作者)\r\rJing Wang, Shaopeng Chen, Hao Cheng, Fangyi Yang, Junting Wan, Jian Bo, Yingxue Liu, Junyun Yang, Jinsong Liu, and Guo-Chun Zhou “Identification, Structural Properties and Chelating Capacity of Miltipolone as a Broad-spectrum Growth Inhibitor to Cancer Cells”, Eur. J. Med. Chem. 2011, 46, 1117-1121. (通讯作者)\r\rQijun Liu, Hong Li, Shaopeng Chen, Guo-Chun Zhou “Synthesis of (3S,4R)-bengamide E”, Chin. Chem. Lett., 2011, 22, 505–507.. (通讯作者)\r\rHuimin Cheng, Lianwen Zhang, Yingxue Liu, Shaopeng Chen, Hao Cheng, Xin Lu, Zhuxia Zheng, Guo-Chun Zhou “Design, Synthesis and Discovery of 5-Hydroxyaurone Derivatives as Growth Inhibitors against HUVEC and Some Cancer Cell Lines”, Eur. J. Med. Chem., 2010, 45, 5950-5957. (通讯作者)\r\rHong Li, Yingxue Liu, Qijun Liu, Wenhui Hu, Guo-Chun Zhou “Asymmetric Synthesis of 2-Amino-5-Hydroxy-Caprolactam Derivatives Mediated by E-Selective Olefination and Asymmetric Oxidation of Enol Ether”, Synthesis, 2010, 23, 4068-4074. (通讯作者)\r\rFangyi Yang, Jie Wang, Hao Cheng, Junting Wan, Zhiyu Xiao, Guo-Chun Zhou “Amplification in vitro of Unknown RNAs and RNA Mixtures Based on Unique Restriction Enzyme Cleavage”, Acta Biochim Biophys Sin, 2010, 42, 873-882. (通讯作者)\r\rXin Liu, Yingyong Ou, Shaopeng Chen, Xin Lu, Hao Cheng, Xian Jia, Decai Wang, Guo-Chun Zhou “Synthesis and inhibitory evaluation of cyclohexen-2-yl and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells”, Eur. J. Med. Chem., 2010, 45, 2147-2153. (通讯作者)\r\rWenjuan Zhang, Jing Xu, Fang Liu, Chunfang Li, Yanling Jie, Shaopeng Chen, Zhiyuan Li, Jinsong Liu, Ling Chen, Guo-ChunZhou “Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A”, Chin J Chem, 2010, 28 (8), 1417-1423. (通讯作者)\r\rYuan Chen, Shaopeng Chen, Xin Lu, Hao Cheng, Yingyong Ou, Huimin Cheng, Guo-Chun Zhou “Synthesis, Discovery and Preliminary SAR Study of Benzofuran Derivatives as Angiogenesis Inhibitors”, Bioorg. Med. Chem. Lett. 2009, 19, 1851-1854. (通讯作者)\r\rZhang, L.; Yan, K.; Zhang, Y.; etal and Guochun Zhou “High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections”, Proc. Natl. Acad. Sci. USA 2007, 104, 4606–4611.\r\rGuo-Chun Zhou, Sapan L. Parikh, Peter C. Tyler, Gary B. Evans, Richard H. Furneaux, Olga V. Zubkova, Paul A. Benjes and Vern L. Schramm “Inhibitors of ADP-Ribosylating Bacterial Toxins Based on Oxacarbenium Ion Character at their Transition States ”,J Am Chem Soc. 2004, 126 (18), 5690-5698.\r\rGuochun Zhou, Chiawei Tsai, Jun O. Liu “Fumagalone, a reversible inhibitor of type 2 methionine aminopeptidase and angiogenesis”, J Med Chem. 2003, 46 (16), 3452-3454. 相关热点
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