个人简历

纪晓俊，教授，博士生导师。 国家自然科学基金优秀青年科学基金获得者。兼任中国化工学会生物化工专业委员会副秘书长，Frontiers in Bioengineering and Biotechnology副主编。\r
2001年9月至2009年12月在南京工业大学本硕博连读，先后获得生物工程学士和生物化工博士学位，博士论文获全国百篇优秀博士论文提名奖。留校工作后承担生物化工领域的教学和科研工作，历任讲师（2010）、副教授（2012）、教授（2018）、博士生导师（2019），先后获得霍英东教育基金会青年教师奖、侯德榜化工科技青年奖等奖励，并先后入选江苏省“333工程”中青年科技带头人、江苏省“六大人才高峰”高层次人才等。2016年8月-2017年8月受国家留学基金委资助在瑞典查尔姆斯理工大学Jens Nielsen教授领导的系统与合成生物学实验室(www.sysbio.se)从事访问研究

研究领域

""代谢工程与合成生物技术指导的生物制造过程，围绕着丝状真菌和非常规酵母两类重要的工业微生物，通过改造或从头设计微生物细胞的代谢途径，实现功能性微生物代谢产物的先进生物制造，进一步通过设计新工艺及新型生物反应器""""

近期论文

1. Ji XJ*, Huang H*. Engineering microbes to produce polyunsaturated fatty acids. Trends in Biotechnology, 2019; 37: 344-346.\r
2. Shi TQ, Gao J, Wang WJ, Wang KF, Xu GQ, Huang H, Ji XJ*. CRISPR/Cas9-based genome-editing in the filamentous fungus Fusarium fujikuroi and its application in strain engineering for gibberellic acid production. ACS Synthetic Biology, 2019; 8: 445-454.\r
3. Ma YR, Wang KF, Wang WJ, Ding Y, Shi TQ, Huang H, Ji XJ*. Advances in the metabolic engineering of Yarrowia lipolytica for the production of terpenoids. Bioresource Technology, 2019;281: 449-456.\r
4. Ding Y, Wang KF, Wang WJ, Ma R, Shi TQ, Huang H, Ji XJ*. Increasing the homologous recombination efficiency of eukaryotic microorganisms for enhanced genome engineering. Applied Microbiology and Biotechnology, 2019; 103: 4313-4324.\r
5. Liu HH, Wang C, Lu XY, Huang H, Tian Y*, Ji XJ*. Improved production of arachidonic acid by combined pathway engineering and synthetic enzyme fusion in Yarrowia lipolytica. Journal of Agricultural and Food Chemistry, 2019; 67: 9851-9857.\r
6. Shi TQ, Huang H, Kerkhoven EJ*, Ji XJ*. Advancing metabolic engineering of Yarrowia lipolytica using the CRISPR/Cas system. Applied Microbiology and Biotechnology, 2018;102:9541-9548.\r
7. Shi K, Gao Z, Lin L, Wang WJ, Shi XQ, Yu X, Song P, Ren LJ, Huang H, Ji XJ*. Manipulating the generation of reactive oxygen species through intermittent hypoxic stress for enhanced accumulation of arachidonic acid-rich lipids. Chemical Engineering Science, 2018;186:36-43.\r
8. Yu Y, Zhang L, Li T, Wu N, Jiang L, Ji XJ*, Huang H*. How nitrogen sources influence Mortierella alpina aging: From the lipid droplet proteome to the whole-cell proteome and metabolome. Journal of Proteomics, 2018; 179: 140-149.\r
9. Guo DS, Ji XJ*, Ren LJ, Li GL, Sun XM, Chen KQ, Gao S, Huang H*. Development of a scale-up strategy for fermentative production of docosahexaenoic acid by Schizochytrium sp. Chemical Engineering Science, 2018;176:600-608.\r
10. Guo DS, Ji XJ*, Ren LJ, Li GL, Huang H*. Improving docosahexaenoic acid production by Schizochytrium sp. using a newly designed high-oxygen-supply bioreactor. AIChE Journal, 2017; 63, 4278-4286.\r
11. Shi TQ, Liu GN, Ji RY, Shi K, Song P, Ren LJ, Huang H, Ji XJ*. CRISPR/Cas9-based genome editing of the filamentous fungi: the state of the art. Applied Microbiology and Biotechnology, 2017; 101: 7435-7443.\r
12. Sun ML, Madzak C, Liu HH, Song P, Ren LJ, Huang H, Ji XJ*. Engineering Yarrowia lipolytica for efficient γ-linolenic acid production. Biochemical Engineering Journal, 2017;117:172-180.\r
13. Liu HH, Madzak C, Sun ML, Ren LJ, Song P, Huang H, Ji XJ*. Engineering Yarrowia lipolytica for arachidonic acid production through rapid assembly of metabolic pathway. Biochemical Engineering Journal, 2017;119:52-58.\r
14. Liu HH, Zeng SY, Shi TQ, Ding Y, Ren LJ, Song P, Huang H, Ji XJ*. A Yarrowia lipolytica strain engineered for arachidonic acid production counteracts metabolic burden by redirecting carbon flux towards intracellular fatty acid accumulation at the expense of organic acids secretion. Biochemical Engineering Journal, 2017; 128: 201-209.\r
15. Tong YJ, Ji XJ*, Shen MQ, Liu LG, Nie ZK, Huang H*. Constructing a synthetic constitutive metabolic pathway in Escherichia coli for (R, R)-2,3-butanediol production. Applied Microbiology and Biotechnology, 2016;100:637-647.\r
16. Ji XJ#*, Liu LG#, Shen MQ, Nie ZK, Tong YJ, Huang H*. Constructing a synthetic metabolic pathway in Escherichia coli to produce the enantiomerically pure (R, R)-2,3-butanediol. Biotechnology and Bioengineering, 2015;112:1056-1059.\r
17. Zhang AH, Ji XJ*, Wu WJ, Ren LJ, Yu YD, Huang H*. Lipid fraction and intracellular metabolite analysis reveal the mechanism of arachidonic acid-rich oil accumulation in the aging process of Mortierella alpina. Journal of Agricultural and Food Chemistry, 2015; 63: 9812-9819.\r
18. Liu HH, Ji XJ*, Huang H*. Biotechnological applications of Yarrowia lipolytica: Past, present and future. Biotechnology Advances, 2015; 33: 1522-1546.\r
19. Ji XJ, Huang H*, Nie ZK, Qu L, Xu Q, Tsao GT. Fuels and chemicals from hemicellulose sugars. Advances in Biochemical Engineering/Biotechnology, 2012; 128: 199-224.