个人简历

Professor
State Key Laboratory of Coordination Chemistry
School of Chemistry & Chemical Engineering
Nanjing University, Jiangsu, China
Professional Experience
2015/07-Present Professor (PI), Nanjing University
School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, China
2013/10-2015/05 Postdoctoral Fellow, Harvard Medical School　Department of Biochemistry and Molecular Medicine, Harvard Medical School, Massachusetts, USA
Advisor: Prof. Timothy A. Springer
Education
2008/09-2013/05 Ph.D., University of British ColumbiaDepartment of Chemistry, University of British Columbia, British Columbia, Canada
2005/09-2008/07 B.S., Nanjing University (Chemistry major)Kuang Yaming Honors School (Department of Intensive Instruction), Nanjing University, Jiangsu, China
2004/09-2005/07 School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, China
News
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Congratulations to Guobin Song and Yibing Deng on passing the dissertation defense...
A new paper by Guobin Song was published on J. Phys. Chem. Lett.
A new paper by Guobin Song was published on Analytical Chemistry
A new paper by Shengchao Shi was published on CCS Chemistry

研究领域

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近期论文

Ma, Q., Liu, L., Yang, Z., Zheng, P.,* Facile Synthesis of Peptide-Conjugated Gold Nanoclusters with Different Lengths.Nanomaterials 11, 2932 (2021) Link·PDF
Liu, Y., Tian, F., Shi, S., Deng, Y., Zheng, P.,* Enzymatic Protein–Protein Conjugation through Internal Site Verified at the Single-Molecule Level. Journal of Physical Chemistry Letters 12, 10914-10919 (2021) Link·PDF
Wang, Z., Nie, J., Shi, S., Li, G., Zheng, P.,* Transforming de novo protein α3D into a mechanically stable protein by zinc binding. Chemical Communications 57, 11489-11492 (2021) Link·PDF
Tian, F.,# Tong, B.,# Sun, L., Shi, S., Zheng, B., Wang, Z., Dong, X.,* & Zheng, P.,* N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2. eLife 10, e69091 (2021) Link · PDF
Yuan, G.,# Curtolo, F.,# Deng, Y.,# Wu, T., Tian, F., Ma, Q., Liu, Y., Zuo, J., Arantes, G. M.* & Zheng, P.* Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule. Research 2021 (2021) Link · PDF
Nie, J., Tian, F., Zheng, B., Wang, Z. & Zheng, P.* Exploration of Metal-Ligand Coordination Bonds in Proteins by Single-Molecule Force Spectroscopy. Chemistry Letters 50, 1667-1675 (2021) Link · PDF
Song, G., Tian, F., Liu, H., Li, G. & Zheng, P.* Pioglitazone Inhibits Metal Cluster Transfer of mitoNEET by Stabilizing the Labile Fe-N Bond Revealed at Single-Bond Level. Journal of Physical Chemistry Letters 12, 3860-3867 (2021) Link · PDF
Shi, S., Wang, Z., Deng, Y., Tian, F., Wu, Q. & Zheng, P.* Combination of SPAAC Click Chemistry and Enzymatic Ligation for Stable and Efficient Protein Immobilization for Single-Molecule Force Spectroscopy, CCS Chemistry 3, 841-847 (2021) Link · PDF
2020
Song, G., Ding, X., Liu, H., Yuan, G., Tian, F., Shi, S., Yang, Y., Li, G. & Zheng, P.* Single-Molecule Force Spectroscopy Reveals that the Fe-N Bond Enables Multiple Rupture Pathways of the 2Fe2S Cluster in a MitoNEET Monomer. Analytical Chemistry 92, 14783-14789 (2020) Link · PDF
Tian, F., Li, G., Zheng, B., Liu, Y., Shi, S., Deng, Y. & Zheng, P.* Verification of sortase for protein conjugation by single-molecule force spectroscopy and molecular dynamics simulations. Chemical Communications 56, 3943-3946 (2020) Link · PDF
Deng, Y., Zheng, B., Liu, Y., Shi, S., Nie, J., Wu, T. & Zheng, P.* OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy. Jove-Journal of Visualized Experiments 156 (2020) Link · PDF
Teixeira, M. H., Curtolo, F., Camilo, S. R. G., Field, M. J., Zheng, P., Li, H. & Arantes, G. M. Modeling the Hydrolysis of Iron-Sulfur Clusters. Journal of Chemical Information and Modeling 60, 653-660 (2020) Link · PDF
2019
Deng, Y., Wu, T., Wang, M., Shi, S., Yuan, G., Li, X., Chong, H., Wu, B. & Zheng, P.* Enzymatic biosynthesis and immobilization of polyprotein verified at the single-molecule level. Nature Communications 10, 2775(2019) Link· PDF
Yuan, G., Ma, Q., Wu, T., Wang, M., Li, X., Zuo, J. & Zheng, P.* Multistep Protein Unfolding Scenarios from the Rupture of a Complex Metal Cluster Cd3S9. Scientific Reports 9 (2019) Link · PDF
Yuan, G., Liu, H., Ma, Q., Li, X., Nie, J., Zuo, J. & Zheng, P.* Single-Molecule Force Spectroscopy Reveals that Iron-Ligand Bonds Modulate Proteins in Different Modes. Journal of Physical Chemistry Letters 10, 5428-5433 (2019) Link ·PDF
Yin, Z., Song, G., Jiao, Y., Zheng, P., Xu, J. & Zhang, X., Dissipative Supramolecular Polymerization Powered by Light, CCS Chemistry 1, 335-342 (2019) Link ·PDF
Lai, J.-C., Jia, X.-Y., Wang, D.-P., Deng, Y.-B., Zheng, P., Li, C.-H., Zuo, J.-L. & Bao, Z. Thermodynamically stable whilst kinetically labile coordination bonds lead to strong and tough self-healing polymers. Nature Communications 10, 1164 (2019) Link · PDF
Zhang, Z., Huang, Q., Tao, X., Song, G., Zheng, P., Li, H., Sun, H. & Xia, W. The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping. Journal of Biological Chemistry 294, 7990-8000 (2019) Link · PDF
2018
Li, H. & Zheng, P. Single molecule force spectroscopy: a new tool for bioinorganic chemistry. Current Opinion in Chemical Biology 43, 58-67 (2018) Link · PDF
2016
Li, C.-H., Wang, C., Keplinger, C., Zuo, J.-L., Jin, L., Sun, Y., Zheng, P., Cao, Y., Lissel, F., Linder, C., You, X.-Z. & Bao, Z. A highly stretchable autonomous self-healing elastomer. Nature Chemistry 8, 619-625 (2016) Link · PDF
2015
Zheng, P., Arantes, G. M., Field, M. J. & Li, H. Force-induced chemical reactions on the metal centre in a single metalloprotein molecule. Nature Communications 6, 7569 (2015) Link · PDF
2014 and Before
Zheng, P., Wang, Y. & Li, H. Reversible Unfolding-Refolding of Rubredoxin: A Single-Molecule Force Spectroscopy Study. Angewandte Chemie-International Edition 53, 14060-14063 (2014) Link · PDF
Zheng, P., Takayama, S.-i. J., Mauk, A. G. & Li, H. Single Molecule Force Spectroscopy Reveals That Iron Is Released from the Active Site of Rubredoxin by a Stochastic Mechanism. Journal of the American Chemical Society 135, 7992-8000 (2013) Link · PDF
Zheng, P., Chou, C.-C., Guo, Y., Wang, Y. & Li, H. Single Molecule Force Spectroscopy Reveals the Molecular Mechanical Anisotropy of the FeS4 Metal Center in Rubredoxin. Journal of the American Chemical Society 135, 17783-17792 (2013) Link · PDF
Zheng, P., Takayama, S.-i. J., Mauk, A. G. & Li, H. Hydrogen Bond Strength Modulates the Mechanical Strength of Ferric-Thiolate Bonds in Rubredoxin. Journal of the American Chemical Society 134, 4124-4131, (2012) Link · PDF
Li, Y. D., Lamour, G., Gsponer, J., Zheng, P. & Li, H. The Molecular Mechanism Underlying Mechanical Anisotropy of the Protein GB1. Biophysical Journal 103, 2361-2368 (2012) Link · PDF
Zheng, P. & Li, H. Highly Covalent Ferric-Thiolate Bonds Exhibit Surprisingly Low Mechanical Stability. Journal of the American Chemical Society 133, 6791-6798 Link · PDF
Zheng, P. & Li, H. Direct Measurements of the Mechanical Stability of Zinc-Thiolate Bonds in Rubredoxin by Single-Molecule Atomic Force Microscopy. Biophysical Journal 101, 1467-1473 (2011) Link · PDF
Zheng, P., Cao, Y. & Li, H. Facile Method of Constructing Polyproteins for Single-Molecule Force Spectroscopy Studies. Langmuir 27, 5713-5718 (2011) Link · PDF
Zheng, P., Cao, Y., Bu, T., Straus, S. K. & Li, H. Single Molecule Force Spectroscopy Reveals that Electrostatic Interactions Affect the Mechanical Stability of Proteins. Biophysical Journal 100, 1534-1541 (2011) Link · PDF