个人简历

南京大学现代工程与应用科学学院教授，博士生导师\r
2007年，北京大学生命科学学院获学士学位\r
2013年，美国亚利桑那州立大学获博士学位\r
2013-2015年，美国耶鲁大学做博士后训练\r
2015年，入选国家高层次人才计划，加入南京大学\r
2018年，入选江苏省双创人才计划

研究领域

"""""课题组主要从事化学和生物学交叉学科方向的研究，以人工核酸为主要研究对象，开展化学生物学和合成生物学方面的研究工作。课题组发展的功能性非天然核酸，可以为肿瘤免疫治疗、肿瘤靶向治疗、解决抗生素耐药性等重要问题，提供新型工具分子和干预手段"

近期论文

A Nucleic Acid Sequence That is Catalytically Active in Both RNA and TNA Backbones Dongying Wei#, Yueyao Wang, Dongfan Song, Ze Zhang, Juan Wang, Jia-Yu Chen, Zhe Li, and Hanyang Yu*ACS Synth Biol. 2022;11(11):3874\r
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DNA-catalysed alternative RNA splicing Dongying Wei#, Mingmei Gao, Jiajie Guo, Yueyao Wang, Xintong Li, Zhe Li*, Hanyang Yu* Chem Commun (Camb). 2022;58(55):7698.\r
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Development of Novel Aptamer-Based Targeted Chemotherapy for Bladder Cancer Yao Wang#，Yang Zhang#，Peng-Chao Li#，Jiajie Guo，Fan Huo，Jintao Yang，Ru Jia，Juan Wang，Qiju Huang，Dan Theodorescu*，Hanyang Yu*，Chao Yan*Cancer Res. 2022; 82(6):1128.\r
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An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination Yueyao Wang#, Yao Wang#, Dongfan Song, Xin Sun, Zhe Li*, Jia-Yu Chen and Hanyang Yu* Nat Chem. 2022; 14(3):350.\r
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A Threose Nucleic Acid Enzyme with RNA Ligase Activity Yao Wang#, Yueyao Wang, Dongfan Song, Xin Sun, Ze Zhang, Xintong Li, Zhe Li, and Hanyang Yu*J. Am. Chem. Soc. 2021;143(21):8154.\r
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Selection of Threose Nucleic Acid Aptamers to Block PD-1/PD-L1 Interaction for Cancer Immunotherapy Xintong Li# , Zhe Li , Hanyang Yu* Chem Commun (Camb).2020;56(93):14653.\r
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Proteomic analysis of cisplatin- and oxaliplatin-induced phosphorylation in proteins bound to Pt-DNA adducts Xin Yuan#, Wanjun Zhang#, Yafeng He, Jian Yuan, Dongfan Song, Hao Chen, Weijie Qin*, Xiaohong Qian, Hanyang Yu*, Zijian Guo*Metallomics. 2020;12(11):1834.\r
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Aptamer-Based Western Blot for Selective Protein Recognition Yao Wang#, Zhe Li, Hanyang Yu*Front Chem. 2020;8:570528.\r
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Direct sequencing of 2'-deoxy-2'-fluoroarabinonucleic acid (FANA) using nanopore-induced phase-shift sequencing (NIPSS).Shuanghong Yan#, Xintong Li#, Panke Zhang, Yuqin Wang, Hong-Yuan Chen, Shuo Huang, and Hanyang Yu* Chem Sci. 2019;10(10):3110. \r
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A Novel Small RNA-Cleaving Deoxyribozyme with a Short Binding Arm. Yueyao Wang#, Jintao Yang, Xin Yuan, Jin Cao, Jiacui Xu, John C. Chaput, Zhe Li* and Hanyang Yu*Sci Rep. 2019;9(1):8224. \r
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Self-Assembly of Large DNA Origami with Custom-Designed Scaffolds Xiaoxing Chen#, Qian Wang#, Jin Peng, Qipeng Long, Hanyang Yu*, and Zhe Li*ACS Appl. Mater. Interfaces. 2018; 10: 24344\r
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An efficient and faithful in vitro replication system for threose nucleic acid H. Yu#, S. Zhang, M. Dunn, and J. C. Chaput*J Am Chem Soc. 2013;135(9):3583.\r
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Synthesis of threose nucleic acid (TNA) triphosphates and oligonucleotides by polymerase-mediated primer extension S. Zhang#, H. Yu, and J. C. Chaput*Curr Protoc Nucleic Acid Chem. 2013;Chapter 4:Unit 4.54.\r
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Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenito H. Yu#, S. Zhang#, and J. C. Chaput*Nat Chem. 2012;4(3):183.\r
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The emerging world of synthetic genetics J. C. Chaput#*, H. Yu, and S. Zhang Chem Biol. 2012;19(11):1360.\r
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Aptamers can discriminate alkaline proteins with high specificity H. Yu#, B. Jiang, and J. C. Chaput* Chembiochem. 2011;12(17):2659. \r
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Generating DNA synbodies from previously discovered peptides R. Liu#, B. Jiang, H. Yu, and J. C. Chaput* Chembiochem. 2011;12(12):1813.