个人简历

闫超博士，2003年获得南京大学生物化学本科学位，2011年获得美国科罗拉多大学毒理学博士学位。2011年到2015年在科罗拉多大学癌症研究中心从事博士后研究。2015年入选 ；2016年起任南京大学药理学教授，博士生导师。

研究领域

主要研究方向为小分子抗肿瘤药物的作用机理和新型靶向药物的研发；实验室的工作涉及小分子抗癌药物的的设计，筛选，合成，药效，药理，和毒理学等药物研发的各个环节。

近期论文

1. Yan C, Jones D, Theodorescu D. Drugging the Ral GTPase. Small GTPases. 2015,6(3):157-9. 2. Yan C, Theodorescu D. One step closer to targeting RAS. Cell Cycle. 2015, 14(3):287-8. 3. Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe EW, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014, 515(7527):443-447. 4. Inman M, Visconti A, Yan C, Siegel D, Ross D, Moody CJ. Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells. Org Biomol Chem. 2014, 12(27):4848-61. 5. Siegel D, Yan C, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012, 83(8):1033-40. 6. Yan C, Siegel D, Newsome J, Chilloux A, Moody CJ, Ross D. Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin teductase and activation of redox signaling. Mol Pharmacol. 2012, 81(3):401-10. 7. Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, and Ross D. Indolequinone inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Characterization of mechanism of inhibition in both cell-free and cellular systems. Biochemistry. 2011, 50(31):6678-88. 8. Dufour M, Yan C (co-first author), Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Siegel D, Li Y, De Matteis CI, Ross D, and Moody CJ. Mechanism-based inhibition of quinone reductase 2 (NQO2). Selectivity for NQO2 over NQO1 and structural basis for inhibition. Chembiochem. 2011, 12(8):1203-8. 9. Siegel D, Shieh B, Yan C, Kepa JK, and Ross D. Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(Allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells. J. Pharmacol. Exp. Ther. 2011, 36(3):874-80. 10. Yan C, Shieh B, Reigan P, Zhang Z, Colucci MA, Chilloux A, Newsome JJ, Siegel D, Chan D, Moody CJ, and Ross D. Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target. Molecular Pharmacology. 2009, 76(1):163-72. 11. Yan C, Kepa JK, Siegel D, Stratford IJ, and Ross D. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). Molecular Pharmacology. 2008, 74(6):1657-65.