个人简历

2009-至今，副教授，南京大学模式动物研究所
2008-2009，Associate Research Scientist, 美国哥伦比亚大学医学院
2003-2008，Research Associate, 美国贝勒医学院

研究领域

小鼠模型
表观遗传
肿瘤复发和转移

近期论文

1. Zhuang J, Lu Q, Shen B, Huang X, Shen L, Huang R, Yan J*, Guo H*. TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT. (under revision in Sci Rep)
2. Li L, Zhang D, Wang X, Yao X, Ye C, Zhang S, Wang H, Xia H, Wang Y, Fang J, Yan J*, Ying H*. Hypoxia-inducible miR-182 enhances HIF1α signaling via targeting PHD2 and FIH1 in prostate cancer. (under revision in Sci Rep)
3. Xu CH, Cao L, Zhang XW, Yan J, Yu LK. Prognostic value of soluble H7-B4 in pleural effusion associated with lung cancer. Tumour Biol. 2015 Feb 1. [Epub ahead of print]
4. Jing Y, Liu W, Cao H, Zhang D, Yao X, Zhang S, Xia H, Li D, Wang YC, Yan J, Hui L, Ying H. Hepatic p38α regulates gluconeogenesis through suppressing AMPK. J Hepatol. 2015 Jan 13. pii: S0168-8278(15)00005-7. doi: 10.1016/j.jhep.2014.12.032
.5. Liu W, Cao H, Ye C, Chang C, Lu M, Jing Y, Zhang D, Yao X, Duan Z, Xia H, Wang YC, Jiang J, Liu MF, Yan J, Ying H. Hepatic miR-378 targets p110α and controls glucose and lipid homeostasis by modulating hepatic insulin signalling. Nat Commun. 2014. 5:5684 doi: 10.1038/ncomms6684
6. Li X, Li Y, Zhao L, Zhang D, Yao X, Zhang H, Wang YC, Wang XY, Xia H, Yan J, Ying H. Circulating muscle-specific miRNAs in Duchenne Muscular Dystrophy patients. Mol Ther Nucleic Acids 2014;3:e177.
7. Liu C, Zhou Z, Yao X, Chen P, Sun M, Su M, Chang C, Yan J, Jiang J, Zhang Q. Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila. Cell Res. 2014;24(5):595-609.
8. Hou Z, Zhao W, Zhou J, Shen L, Zhan P, Xu C, Chang C, Bi H, Zou J, Yao X, Huang R, Yu L*, Yan J*. A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. Int J Biochem Cell Biol. 2014; 53: 380-388.
9. Zhou J, Bi H, Zhan P, Chang C, Xu C, Huang X, Yu L, Yao X*, Yan J*. Overexpression of HP1g is associated with poor prognosis in non-small cell lung cancer cell through promoting cell survival. Tumor Biol. 2014; 35(10):9777-9785.
10. Zhao W, Chang C, Cui Y, Zhao X, Yang J, Shen L, Zhou J, Hou Z, Zhang Z, Ye C, Hasenmayer D, Perkins R, Huang X, Yao X, Yu L, Huang R, Zhang D, Guo H*, Yan J*. Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible-factor 1α. J Biol Chem. 2014;289(16):11219- 11229.
11. Wang YC, Li Y, Wang XY, Zhang D, Zhang H, Wu Q, He YQ, Wang JY, Zhang L, Xia H, Yan J, Li X, Ying H. Circulating miR-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity. Diabetologia. 2013;56:2275-85.
12. Wang J, Wang X, Song Y, Wang J, Zhang C, Chang C, Yan J, Qiu L, Wu M, Guo Z. A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticlest. Chem Sci. 2013.4:2605-2612.
13. Zhao Q, Xie B, Yan J, Zhao F, Xiao J, Yao L, Zhao B, Huang Y. In vitro anti-oxidant and antitumor activities of polysaccharides extracted from Asparagus officinalis. Carbohydr Polym. 2012;87(1):392-396.
14. Song Y, Shan S, Zhang Y, Liu W, Ding W, Ren W, Xia H, Li X, Zhang Q, Zhao L, Li X, Yan J, Ying H. Ligand-Dependent Corepressor acts as a novel corepressor of thyroid hormone receptor β1 and represses hepatic lipogenesis in mice. J Hepatol. 2012; 56(1):248-254.
15. Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L, Tsai SY, Tsai MJ. The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 2009; 9:77-87.
16. Ayala G, Yan J, Rile Li, Deng Y, Thompson TC, Mims M, Hayes T, MacDonnell V, Lynch G, Frolov A, Miles B, Wheeler T, Harper W, Tsai MJ, Ittmann M, Kadmon D. Bortezomib mediated inhibition of SRC-3 degradation leads to activated AKT. Clin. Cancer Res. 2008; 14:7511-7518.
17. Kinkade CW, Castillo-Martin M, Puzio-Kuter A, Yan J, Foster TH, Gao H, Sun Y, Ouyang X, Gerald WL, Cordon-Cardo C, Abate-Shen C. Targeting Akt/mTor and MEK/Erk MAP kinase signaling inhibits hormone-refractory prostate cancer in a pre-clinical mouse model. J Clin. Invest. 2008; 118:3051-3064.
18. Yan J, Erdem H, Li R, Cai Y, Ayala G, Ittmann M, Yu-Lee L, Tsai SY, Tsai MJ. SRC-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res. 2008; 68:5460-5468.
19. Yan J, Yu CT, Ozen M, Ittmann M, Tsai SY, Tsai MJ. Steroid receptor coactivator-3 and AP-1 coordinately regulates the transcription of components of the IGF/AKT signaling pathway. Cancer Res. 2006; 66: 11039-11046.
20. Zhou HJ, Yan J, Luo W, Ayala G, Lin SH, Erdem H, Ittmann M, Tsai SY, Tsai MJ. SRC-3 is required for prostate cancer cell proliferation and survival. Cancer Res. 2005; 65: 7976-7983.