个人简历

2005.2-至今，南京大学医学院附属鼓楼医院神经内科主任医师、教授、博导、行政主任、国务院政府特殊津贴专家
2003.10-2005.02，南京大学医学院附属鼓楼医院神经科副主任，主任医师，教授
2000.03-2009.09，美国霍普金斯大学博士后研究
1998.03-1999.03，德国海德堡大学神经科访问学者
1995.06-2000.03，扬州大学医学院，副主任医师、副教授
1982.08-1992.09，扬州市第二人民医院 神经科医师、主治医师

研究领域

脑血管病的基础和临床研究
认知障碍的基础和临床研究
干细胞基础和临床转化研究

近期论文

1. Xu Y, Zhang W, Klaus J, Young J, Koerner I, Sheldahl LC, Hurn PD, Martínez-Murillo F,Alkayed NJ. Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Proc Natl Acad Sci U S A. 2006, 103:14489-14494.
2. Zhang M, Wang S, Mao L, Leak R, Shi Y, Zhang W, Hu X, Sun B, Cao G, Gao Y, Xu Y, Chen J, Zhang F. Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1. J Neurosci. 2014, 34:1903-15.
3. Sun Z, Chen Z, Jiang H, Li L, Li E, Xu Y*. Alteration of Ab metabolism-related molecules in predementia induced by AlCl3 and D-galactose. Age (Dordr). 2009,4:277-84.
4. Jia D, Chen Z, Zhang M, Yang W, Jin J, Xia Y, Zhang C, Shao Y, Chen C, Xu Y*. CYP2C19 Polymorphisms and Antiplatelet Effects of Clopidogrel in Acute Ischemic Stroke in China. Stroke. 2013,44:1717-9.
5. Xu Y, Traystman RJ, Hurn PD, Wang MM. Membrane restraint of estrogen receptor alpha enhances estrogen-dependent nuclear localization and genomic function. Mol Endocrinol. 2004, 18:86-96.
6. Zhu X, Ye L, Ge H, Chen L, Jiang N, Qian L, Li L, Liu R, Ji S, Zhang S, Jin J, Guan D, Fang W, Tan R, Xu Y*. Hopeahainol A attenuates memory deficits by targeting b-amyloid in APP/PS1 transgenic mice. Aging Cell. 2013.1:85-92.
7. Zhu X, Wang S, Yu L, Yang H, Tan R, Yin K, Jin J, Zhao H, Guan D, Xu Y. TL-2 attenuates b-amyloid induced neuronal apoptosis through the AKT/GSK-3b/b-catenin pathway. Int J Neuropsychopharmacol. 2014,19:1-9.
8. Niu F, Zhang X, Hu X, Chen J, Chang L, Li J, Liu Z, Cao W, Xu Y. Targeted mutation of Fas ligand gene attenuates brain inflammation in experimental stroke. Brain Behav Immun. 2012, 26:61-71.
9. Zhang M, Li Q, Chen L, Li J, Zhang X, Chen X, Zhang Q, Shao Y, Xu Y.PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia.Neurobiol Dis. 2014 ,68:104-11.
10. Jin JL, Liou AK, Shi Y, Yin KL, Chen L, Li LL, Zhu XL, Qian L, Yang R, Chen J, Xu Y.CART treatment improves memory and synaptic structure in APP/PS1 mice.Sci Rep. 2015 May 11;5:10224. doi: 10.1038/srep10224
11. Pan J, Jin JL, Ge HM, Yin KL, Chen X, Han LJ, Chen Y, Qian L, Li XX, Xu Y. Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner.J Neuroinflammation. 2015 Mar 14;12(1):51. doi: 10.1186/s12974-015-0270-3.
12. Chang L, Chen Y, Li J, Liu Z, Wang Z, Chen J, Cao W, Xu Y*. Cocaine-and amphetamine-regulated transcript modulates peripheral immunity and protects against brain injury in experimental stroke. Brain Behav Immun. 2011,2:260-9.
13. Zhu H, Wang Z, Zhu X, Wu X, Li E, Xu Y*. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha Expression in experimental stroke. Neuropharmacology. 2010,1-2:70-6.
14. Liu R, Zhang Z, Lu Z, Borlongan C, Pan J, Chen J, Qian L, Liu Z, Zhu L, Zhang J, Xu Y*. Human umbilical cord stem cells ameliorate experimental autoimmune encephalomyelitis by regulating immunoinflammation and remyelination. Stem Cells Dev . 2013,22:1053-62.
15. Chen Z, Huang D, Niu F, Zhang X, Lia E, Xu Y. Human Urinary Kallidinogenase Suppresses Cerebral Inflammations in Experimental Stroke via Down-regulation of Nuclear Factor-ｋB. JCBFM. 2010, 30:1356-65.