个人简历
学习和进修经历2016-09至2019-06，南京大学，生命科学学院，博士，导师: 戈惠明2013-09至2016-06，南京大学，生命科学学院，硕士, 导师: 焦瑞华2009-09至2013-06，山东中医药大学，药学院，学士工作经历：2019-07至2021-06，南京大学, 生命科学学院, 博士后, 合作导师: 戈惠明2021-07至今，南京大学, 生命科学学院, 副研究员, 合作导师: 戈惠明主持项目：1. 中国博士后科学基金，第66批面上资助，2019M661797，含肉桂酰非核糖体肽类化合物的基因挖掘和生物合成研究，2020-01至2021-12，8万，在研，主持。2. 中国博士后科学基金，第13批特别资助（站中），2020T130290，基因信息指导的新型肉桂酰多肽的发现，2020-01至2021-12，18万，在研，主持。3. 国家重点研发计划子课题，2019YFC0312504，2019-08至2020-12，73万，在研，主持。4. 中央高校基本科研业务费国家重点平台研究项目，肉桂酰非核糖体多肽的基因挖掘，2020-01至2020-12，13万，结题，主持。5. 国家自然科学基金委员会，面上项目，81773591，新型beta-内酯化合物strepenlactone的生物合成研究，2018-01至2021-12，54万，在研，参加。6. 国家自然科学基金委员会，面上项目，21572100，一类抗幽门螺旋杆菌大环内酯化合物的生物合成研究，2016-01至2019-12，77万，已结题，参加。专利1. 戈惠明、杨成龙、史净、王佳琦，龙纳霉素及其制备方法和应用，中国，20190863023.8。2. 戈惠明、史净、郭文洁、刘程丽、韩浩，肯塔森纳霉素及其制备方法和应用, 中国，201910195394.3。
研究领域
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近期论文
1. Jing Shi, Jiaqi Ma, Yongchao Wang, Zifei Xu, Bo Zhang, Ruihua Jiao, Ren Xiang Tan, Hui Ming Ge,*Discovery of daspyromycins A and B, 2-aminovinyl-cysteine containing lanthipeptides, through a genomics-based approach. Chinese Chemical Letters, accepted 31 May 2021.2. Jing Shi#; Xiang Xu#; Pei Yi Liu; Yi Ling Hu; Bo Zhang; Rui Hua Jiao; Ghader Bashiri; Ren Xiang Tan*; Hui Ming Ge*, Discovery and biosynthesis of guanipiperazine from a NRPS-like pathway. Chemical science, 2021, 12, 2925-2930.3. Jing Shi#; Cheng Li Liu; Bo Zhang; Wen Jie Guo;Jiapeng Zhu;Chin-Yuan Chang; Er Juan Zhao;Rui Hua Jiao;Ren Xiang Tan*; Hui Ming Ge*, Genome mining and biosynthesis of kitacinnamycins as a STING activator. Chemical science, 2019, 10, 4839-4846.4. Jing Shi; Ying Jie Zeng ; Bo Zhang; Fen Li Shao; Yan Chi Chen; Xiang Xu; Yang Sun; Qiang Xu; Ren Xiang Tan*; Hui Ming Ge*, Comparative genome mining and heterologous expression of an orphan NRPS gene cluster direct the production of ashimides. Chemical science, 2019, 10, 3042-3048.5. Jing Shi#; Xiang Xu#; Er Juan Zhao; Bo Zhang; Wei Li; Yang Zhao; Rui Hua Jiao; Ren Xiang Tan*; Hui Ming Ge* ;Genome Mining and Enzymatic Total Biosynthesis of Purincyclamide. Organic Letters,2019, 21, 6825-6829. 6. Li Zhang; Jing Shi; Cheng Li Liu; Lang Xiang; Shi Ying Ma; Wei Li; Rui Hua Jiao; Ren Xiang Tan*; Hui Ming Ge*; New borrelidin derivatives from an endophytic Streptomyces sp. Tetrahedron Letters, 2018, 59,4517-4520.7. Zi Fei Xu, Sheng Tao Bo, Mei Jing Wang,Jing Shi, Rui Hua Jiao, Yang Sun, Qiang Xu, Ren Xiang Tan* and Hui Ming Ge*; iscovery and biosynthesis of bosamycins from treptomyces sp. 120454. Chemical science, 2020, 11, 9237-9245.8. Wei Li, Fang Wen Jiao, Jia Qi Wang, Jing Shi, Ting Ting Wang, Salman Khan, Rui Hua Jiao, Ren Xiang Tan*, Hui Ming Ge*;Unguisin G, a new kynurenine-containing cyclic heptapeptide from the sponge-associated fungus Aspergillus candidus NF2412. Tetrahedron Letters, 2020, 61, 152322-152326.9. Cheng Long Yang, Bo Zhang, Wen Wen Xue, Wu Li, Zi Fei Xu, Jing Shi, Yan Shen, Rui Hua Jiao, Ren Xiang Tan, and Hui Ming Ge*; Discovery, Biosynthesis, and Heterologous Production of Loonamycin, a Potent Anticancer Indolocarbazole Alkaloid. Organic Letters,2020,22, 4665-4669.10. Yingzi Tan, Zhikai Guo, Mengyue Zhu, Jing Shi, Wei Li, Ruihua Jiao, Renxiang Tan, Huiming Ge*; Anti-inflammatory spirobisnaphthalene natural products from a plant-derived endophytic fungus Edenia gomezpompae. Chinese Chemical Letters, 2020, 31, 1406-1409.11. Hao Han, Zhi Kai Guo, Bo Zhang, Mei Zhang, Jing Shi, Wei Li, Ruihua Jiao, Renxiang Tan, Huiming Ge*; Bioactive phenazines from an earwig-associated Streptomyces sp. Chinese Journal of Natural Medicines, 2019, 17, 475-480.12. Shuang He Liu, Wen Wang, Kai Biao Wang, Bo Zhang, Wei Li, Jing Shi, Rui Hua Jiao, Ren Xiang Tan, and Hui Ming Ge*; Heterologous Expression of a Cryptic Giant Type I PKS Gene Cluster Leads to the Production of Ansaseomycin. Organic Letters, 2019, 21, 3758-3788.13. Bo Zhang, Kai Biao Wang, Wen Wang, Xin Wang, Fang Liu, Jiapeng Zhu, Jing Shi, Ling Yu Li, Hao Han, Kuang Xu, Hong Yun Qiao, Xiao Zhang, Rui Hua Jiao, Kendall N. Houk*, Yong Liang*, Ren Xiang Tan*, Hui Ming Ge*; Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products. Nature, 2019, 568, 122-126.14. Chengli Liu, Chenglong Yang, Yingjie Zeng, Jing Shi, Lingyu Li, Wei Li, Ruihua Jiao, Renxiang Tan, Huiming Ge*; Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069. Chinese Chemical Letters, 2019, 30, 44-46.15. Yong Sheng Xiao, Bo Zhang, Mei Zhang, Zhi Kai Guo, Xin Zhao Deng, Jing Shi, Wei Li, Rui Hua Jiao, Ren Xiang Tan*, Hui Ming Ge*; Rifamorpholines A-E, Potential Antibiotics from a Locust-Associated Actinobacteria Amycolatopsis sp. Hca4. Org. Biomol. Chem., 2017,15, 3909-3916.16. Mei Zhang, Cheng Long Yang, Yong Sheng Xiao, Bo Zhang, Xin Zhao Deng, Li Yang,Jing Shi, Yi Shuang Wang, Wei Li, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge*; Aurachin SS, a new antibiotic from Streptomyces sp. NA04227. The Journal of Antibiotics, 2017, 70, 853-855.17. Wenjing Zhang, Wei Wei, Jing Shi, Chaojun Chen, Guoyan Zhao, Ruihua Jiao*, Ren Xiang Tan*; Natural Phenolic Metabolites from Endophytic Aspergillus sp. IFB-YXS with Antimicrobial Activity. Bioorg. Med. Chem. Lett.2015, 25, 2698-2701.
