个人简历

2014.07-至今，副教授，南京大学生命科学学院
2011.07-2014.06，专职助理研究员，南京大学生命科学学院

研究领域

肥胖与Ⅱ型糖尿病的分子机制
心血管疾病分子机制与治疗
从事哺乳动物代谢性疾病的研究，尤其是肥胖导致的Ⅱ型糖尿病和心血管疾病。主要是从转录和转录后加工水平对线粒体的功能进行研究，从线粒体的生理功能到病理转变的全新角度，解释多种代谢性疾病潜在的分子生物学机制与联系。对各种代谢性疾病，尤其是肥胖引起的代谢综合症，从回复线粒体功能，恢复机体能量平衡的角度寻找新的更有效治疗途径和药物靶点

近期论文

1. Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA--149-3p and suppression of PRDM16. Nature Communications. (2016) May 31; 7:11533. Ding H, Zheng S, Garcia-Ruiz D, Hou D, Wei Z, Liao Z, Li L, Zhang Y, Han X, Zen K, Zhang CY, Li J, Jiang X.
2. Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse. Sci Rep. (2015) Dec 3; 5:17543. Liu Y, Li D, Liu Z, Zhou Y, Chu D, Li X, Jiang X, Hou D, Chen X, Chen Y, Yang Z, Jin L, Jiang W, Tian C, Zhou G, Zen K, Zhang J, Zhang Y, Li J, Zhang CY.
3. MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis. Atherosclerosis. (2015) Aug; 241(2):671-81. Xue Y, Wei Z, Ding H, Wang Q, Zhou Z, Zheng S, Zhang Y, Hou D, Liu Y, Zen K, Zhang CY, Li J, Wang D, Jiang X.
4. Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression. Protein Cell. (2015) Jun;6(6):391-6.Li J, Zhang Y, Li D, Liu Y, Chu D, Jiang X, Hou D, Zen K, Zhang CY.
5. Oral Delivery of a Novel Attenuated Salmonella Vaccine Expressing Influenza A Virus Proteins Protects Mice against H5N1 and H1N1 Viral Infection. PLoS One. (2015) Jun 17; 10(6):e0129276. Pei Z, Jiang X, Yang Z, Ren X, Gong H, Reeves M, Sheng J, Wang Y, Pan Z, Liu F, Wu J, Lu S.
6. Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance through inhibition of PTP1B. Diabetologia. (2014) Oct; 57(10):2145-54.Ding H, Zhang Y, Xu C, Hou D, Li J, Zhang Y, Peng W, Zen K, Zhang CY, Jiang X.
7. MicroRNA-495 induces breast cancer cell migration by targeting JAM-A. Protein Cell. (2014) Cao M, Nie W, Li J, Zhang Y, Yan X, Guan X, Chen X, Zen K, Zhang CY, Jiang X, Hou D.
8. Directing RNase P-mediated cleavage of target mRNAs by engineered external guide sequences in cultured cells. Methods Mol Biol. 2014 1103: 45-56. Jiang X, Sunkara N, Lu S, Liu F.
9. Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reaction. J Biol Chem. (2014) Mar 21; 289(12):8432-41. Shi L, Zhang Q, Xu B, Jiang X, Dai Y, Zhang CY, Zen K.
10. miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. Eur J Cancer. (2014) Mar; 50(5):1013-24. Cao M, Hou D, Liang H, Gong F, Wang Y, Yan X, Jiang X, Wang C, Zhang J, Zen K, Zhang CY, Chen X.
11. The smallest capsid protein mediates binding of the essential tegument protein pp150 to stabilize DNA-containing capsids in human cytomegalovirus. PLoS Pathog. (2013) Aug; 9(8):e 1003525. Dai X, Yu X, Gong H, Jiang X, Abenes G, Liu H, Shivakoti S, Britt WJ, Zhu H, Liu F, Zhou ZH.
12. Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis. J Biol Chem. (2013) Aug 9; 288(32):23586-96. Li J, Zhang Y, Liu Y, Dai X, Li W, Cai X, Yin Y, Wang Q, Xue Y, Wang C, Li D, Hou D, Jiang X, Zhang J, Zen K, Chen X, Zhang CY.
13. Effective inhibition of cytomegalovirus infection by external guide sequences in mice. Proc Natl Acad Sci USA. (2012) Aug 7; 109 (32):13070-5. Jiang X, Gong H, Chen YC, Vu GP, Trang P, Zhang CY, Lu S, Liu F.
14. Ribonuclease P-mediated inhibition of human cytomegalovirus gene expression and replication induced by engineered external guide sequences. RNA Biol. (2012) Sep 9 (9):1186-95. Jiang X, Chen YC, Gong H, Trang P, Lu S, Liu F.
15. The inhibitory effect of dexamethasone on platelet-derived growth factor -induced vascular smooth muscle cell migration through up-regulating PGC-1α expression. Exp Cell Res. (2011) May 1; 317(8):1083-92. Xu W, Guo T, Zhang Y, Jiang X, Zhang Y, Zen K, Yu B, Zhang CY.
16. Engineered external guide sequences effectively block viral gene expression and replication in cultured cells. J Biol Chem. (2011) Jan 7; 286(1): 322-30. Jiang X, Rider P, Kim K, Zhang CY, Lu S, Liu F.
17. 17beta-estradiol inhibits oleic acid-induced rat VSMC proliferation and migration by restoring PGC-1alpha expression. Mol Cell Endocrinol. (2010) Feb 5; 315(1-2):74-80. Jiang X, Zhang Y, Hou D, Zhu L, Xu W, Ding L, Qi X, Sun G, Liu C, Zhang J, Zen K, Xiang Y, Zhang CY.
18. PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS One. (2009); 4(1):e4182.Zhu L, Sun G, Zhang H, Zhang Y, Chen X, Jiang X, Jiang X, Krauss S, Zhang J, Xiang Y, Zhang CY.
19. PGC-1alpha inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells. PLoS One. (2007) Nov 7; 2(11):e1137. Zhang Y, Liu C, Zhu L, Jiang X, Chen X, Qi X, Liang X, Jin S, Zhang P, Li Q, Wang D, Liu X, Zeng K, Zhang J, Xiang Y, Zhang CY.