个人简历

1994年获美国Thomas Jefferson University发育生物学与解剖学专业博士学位，南京大学模式动物研究所创始人。2000年受聘为南京大学教授，2002年受聘为博士生导师及教育部长江奖励计划特聘教授，2008年获国家杰出青年科学基金。国家科技进步二等奖和教育部科技进步特等奖获得者。
基金种类　基金项目名称
中国科学技术部　发育编程及其代谢调节
中国科学技术部　建立国家突变小鼠研究中心
中国科学技术部　通过ENU诱变大规模筛选突变小鼠
江苏省科技厅　用微阵列分析糖尿病小鼠肾脏的基因表达谱
中国科学技术部　几种小鼠疾病模型的表型分析
中国科学技术部　中国小鼠生物信息学数据库平台的建立
中国教育部　肿瘤转移中的PRL-3信号传导
中国自然科学基金　TLR信号在心脏肥大发育调节中的作用
中国教育部　基于血管分子生物学的药物发现和开发
中国科学技术部先天性心脏病发生和筛选小鼠突变体
中国自然科学基金　杰出青年学者基金会
中国科学技术部　为疾病模型生成小鼠突变体
江苏省科技厅　中国突变小鼠资源中心创新研究
中国科学技术部　使用CRISPR / Cas9技术系统生成大鼠疾病模型
中国自然科学基金　用染色体置换研究野生小鼠基因组异质性
江苏省科技厅　发用于药物研发的新型小鼠模型
中国科学技术部　为NRCMM建立无菌小鼠设施

研究领域

本实验室主要研究方向为免疫和代谢对生理稳态的调控及其失调引起的复杂疾病。我们通过基因工程小鼠模型分析多器官或者生物系统来解析生理稳态调控中复杂的基本问题：包括确定大脑、肝脏、脂肪、骨骼、肠道和免疫系统中基因的功能，以及肠道微生物与宿主之间的相互作用。我们希望能够解析这些器官和生物是如何共同工作调节生物体的生理稳态。近年来实验室的工作包括：PP2A-C敲除能够促进肝脏对葡萄糖的处理能力；解析肠道微生物和免疫系统对机体代谢的影响；确定了组蛋白甲基化程度通过下丘脑中雌激素环路影响雌性代谢的机制；在国际上首次证明了Gasdermin家族蛋白的N端在细胞死亡中起关键作用，并通过对脓毒症（Sepsis）模型小鼠的研究，发现了多种Gasdermin相关的细胞焦亡调控机制；通过建立和分析肥胖记忆模型小鼠，首次发现了适应性免疫中的CD4+ T细胞能够储存肥胖记忆""

近期论文

1. Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren, X. Gao, and Z. Lin, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652.
2. Zheng, J., D. Wang, Q. Chen, Q. Liu, Z. Lin, Q. Hu, X. Wu, X. Gao, Q. Li, and J. Ren, Hypertonic saccharide solution delays pyroptosis in murine macrophages regardless of the membrane binding of gasdermin D N-terminal. Eur J Immunol, 2020. 50(3): p. 464-467.
3. Zhang, T., P. Xie, Y. Dong, Z. Liu, F. Zhou, D. Pan, Z. Huang, Q. Zhai, Y. Gu, Q. Wu, N. Tanaka, Y. Obata, A. Bradley, C.J. Lelliott, L.M.J. Nutter, C. McKerlie, A.M. Flenniken, M.F. Champy, T. Sorg, Y. Herault, M.H. Angelis, V.G. Durner, A.M. Mallon, S.D.M. Brown, T. Meehan, H.E. Parkinson, D. Smedley, K.C.K. Lloyd, J. Yan, X. Gao, J.K. Seong, C.L. Wang, R. Sedlacek, Y. Liu, J. Rozman, L. Yang, and Y. Xu, High-throughput discovery of genetic determinants of circadian misalignment. PLoS Genet, 2020. 16(1): p. e1008577.
4. Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao, J. Ren, and Z. Lin, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481.
5. Lloyd, K.C.K., D.J. Adams, G. Baynam, A.L. Beaudet, F. Bosch, K.M. Boycott, R.E. Braun, M. Caulfield, R. Cohn, M.E. Dickinson, M.S. Dobbie, A.M. Flenniken, P. Flicek, S. Galande, X. Gao, A. Grobler, J.D. Heaney, Y. Herault, M.H. de Angelis, J.R. Lupski, S. Lyonnet, A.M. Mallon, F. Mammano, C.A. MacRae, R. McInnes, C. McKerlie, T.F. Meehan, S.A. Murray, L.M.J. Nutter, Y. Obata, H. Parkinson, M.S. Pepper, R. Sedlacek, J.K. Seong, T. Shiroishi, D. Smedley, G. Tocchini-Valentini, D. Valle, C.L. Wang, S. Wells, J. White, W. Wurst, Y. Xu, and S.D.M. Brown, The Deep Genome Project. Genome Biol, 2020. 21(1): p. 18.
6. Jiang, H., L. Zhang, X. Liu, W. Sun, K. Kato, C. Chen, X. Li, T. Li, Z. Sun, W. Han, F. Zhang, Q. Xiao, Z. Yang, J. Hu, Z. Qin, R.H. Adams, X. Gao, and Y. He, Angiocrine FSTL1 (Follistatin-Like Protein 1) Insufficiency Leads to Atrial and Venous Wall Fibrosis via SMAD3 Activation. Arterioscler Thromb Vasc Biol, 2020. 40(4): p. 958-972.
7. Huang, C., T. Liu, Q. Wang, W. Hou, C. Zhou, Z. Song, Y.S. Shi, X. Gao, G. Chen, Z. Yin, and Y. Hu, Loss of PP2A Disrupts the Retention of Radial Glial Progenitors in the Telencephalic Niche to Impair the Generation for Late-Born Neurons During Cortical Developmentdagger. Cereb Cortex, 2020.
8. Zhou, S., Y. Li, L. Qiao, Y. Ge, X. Huang, X. Gao, H. Ju, W. Wang, J. Zhang, J. Yan, H. Teng, and Q. Jiang, Inactivation of Lkb1 in postnatal chondrocytes leads to epiphyseal growth-plate abnormalities and promotes enchondroma-like formation. FASEB J, 2019. 33(8): p. 9476-9488.
9. Zheng, M., D. Li, Z. Zhao, D. Shytikov, Q. Xu, X. Jin, J. Liang, J. Lou, S. Wu, L. Wang, H. Hu, Y. Zhou, X. Gao, and L. Lu, Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection. Proc Natl Acad Sci U S A, 2019. 116(25): p. 12422-12427.
10. Yuan, X., X. Qin, D. Wang, Z. Zhang, X. Tang, X. Gao, W. Chen, and L. Sun, Mesenchymal stem cell therapy induces FLT3L and CD1c(+) dendritic cells in systemic lupus erythematosus patients. Nat Commun, 2019. 10(1): p. 2498.
11. Xu, Q., X. Jin, M. Zheng, D. Rohila, G. Fu, Z. Wen, J. Lou, S. Wu, R. Sloan, L. Wang, H. Hu, X. Gao, and L. Lu, Phosphatase PP2A is essential for TH17 differentiation. Proc Natl Acad Sci U S A, 2019. 116(3): p. 982-987.
12. Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao, and Z. Lin, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019.
13. Wang, J., R. Xie, X. Kou, Y. Liu, C. Qi, R. Liu, W. You, J. Gao, and X. Gao, A protein phosphatase 2A deficit in the hippocampal CA1 area impairs memory extinction. Mol Brain, 2019. 12(1): p. 51.
14. Quan, C., M. Li, Q. Du, Q. Chen, H. Wang, D. Campbell, L. Fang, B. Xue, C. MacKintosh, X. Gao, K. Ouyang, H.Y. Wang, and S. Chen, SPEG Controls Calcium Reuptake Into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain. Circ Res, 2019. 124(5): p. 712-726.
15. Ma, P., N.N. Song, Y. Li, Q. Zhang, L. Zhang, L. Zhang, Q. Kong, L. Ma, X. Yang, B. Ren, C. Li, X. Zhao, Y. Li, Y. Xu, X. Gao, Y.Q. Ding, and B. Mao, Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Rep, 2019. 28(2): p. 541-553 e4.
16. Lai, S.S., X. Fu, Q. Cheng, Z.H. Yu, E.Z. Jiang, D.D. Zhao, D.C. Yu, Y.D. Qiu, X. Gao, H.X. Ju, W. Wang, Q. Jiang, M.S. Zhu, C.J. Li, and B. Xue, HSC-specific knockdown of GGPPS alleviated CCl4-induced chronic liver fibrosis through mediating RhoA/Rock pathway. Am J Transl Res, 2019. 11(4): p. 2382-2392.
17. Giannuzzi, G., P.J. Schmidt, E. Porcu, G. Willemin, K.M. Munson, X. Nuttle, R. Earl, J. Chrast, K. Hoekzema, D. Risso, K. Mannik, P. De Nittis, E.D. Baratz, Y. Herault, X. Gao, C.C. Philpott, R.A. Bernier, Z. Kutalik, M.D. Fleming, E.E. Eichler, and A. Reymond, The Human-Specific BOLA2 Duplication Modifies Iron Homeostasis and Anemia Predisposition in Chromosome 16p11.2 Autism Individuals. Am J Hum Genet, 2019. 105(5): p. 947-958.
18. Geng, L., X. Tang, K. Zhou, D. Wang, S. Wang, G. Yao, W. Chen, X. Gao, W. Chen, S. Shi, N. Shen, X. Feng, and L. Sun, MicroRNA-663 induces immune dysregulation by inhibiting TGF-beta1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Cell Mol Immunol, 2019. 16(3): p. 260-274.
19. Gao, J., A. Qin, D. Liu, R. Ruan, Q. Wang, J. Yuan, T.S. Cheng, A. Filipovska, J.M. Papadimitriou, K. Dai, Q. Jiang, X. Gao, J.Q. Feng, H. Takayanagi, C. Zhang, and M.H. Zheng, Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network. Sci Adv, 2019. 5(11): p. eaaw7215.
20. Dai, J., S. Zhou, Q. Ge, J. Qin, J. Li, H. Ju, Y. Cao, M. Zheng, C. Li, X. Gao, H. Teng, and Q. Jiang, Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression. J Orthop Surg Res, 2019. 14(1): p. 59.
21. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren, Z. Lin, and X. Gao, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508.
22. Chen, Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X. Gao, and Z. Lin, Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.
23. Zou, J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P. Shi, X. Tu, D. Wang, L. Lu, Z. Lin, and X. Gao, CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, 2018. 15(6): p. 630-639.
24. Yu, F., X. Han, K. Zhang, B. Dai, S. Shen, X. Gao, H. Teng, X. Wang, L. Li, H. Ju, W. Wang, J. Zhang, and Q. Jiang, Evaluation of a polyvinyl alcohol-alginate based hydrogel for precise 3D bioprinting. J Biomed Mater Res A, 2018.
25. Wang, Q., J. Tang, S. Jiang, Z. Huang, A. Song, S. Hou, X. Gao, and H.B. Ruan, Inhibition of PPARgamma, adipogenesis and insulin sensitivity by MAGED1. J Endocrinol, 2018.
26. Rozman, J., B. Rathkolb, M.A. Oestereicher, C. Schutt, A.C. Ravindranath, S. Leuchtenberger, S. Sharma, M. Kistler, M. Willershauser, R. Brommage, T.F. Meehan, J. Mason, H. Haselimashhadi, I. Consortium, T. Hough, A.M. Mallon, S. Wells, L. Santos, C.J. Lelliott, J.K. White, T. Sorg, M.F. Champy, L.R. Bower, C.L. Reynolds, A.M. Flenniken, S.A. Murray, L.M.J. Nutter, K.L. Svenson, D. West, G.P. Tocchini-Valentini, A.L. Beaudet, F. Bosch, R.B. Braun, M.S. Dobbie, X. Gao, Y. Herault, A. Moshiri, B.A. Moore, K.C. Kent Lloyd, C. McKerlie, H. Masuya, N. Tanaka, P. Flicek, H.E. Parkinson, R. Sedlacek, J.K. Seong, C.L. Wang, M. Moore, S.D. Brown, M.H. Tschop, W. Wurst, M. Klingenspor, E. Wolf, J. Beckers, F. Machicao, A. Peter, H. Staiger, H.U. Haring, H. Grallert, M. Campillos, H. Maier, H. Fuchs, V. Gailus-Durner, T. Werner, and M. Hrabe de Angelis, Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun, 2018. 9(1): p. 288.
27. Moore, B.A., B.C. Leonard, L. Sebbag, S.G. Edwards, A. Cooper, D.M. Imai, E. Straiton, L. Santos, C. Reilly, S.M. Griffey, L. Bower, D. Clary, J. Mason, M.J. Roux, H. Meziane, Y. Herault, C. McKerlie, A.M. Flenniken, L.M.J. Nutter, Z. Berberovic, C. Owen, S. Newbigging, H. Adissu, M. Eskandarian, C.W. Hsu, S. Kalaga, U. Udensi, C. Asomugha, R. Bohat, J.J. Gallegos, J.R. Seavitt, J.D. Heaney, A.L. Beaudet, M.E. Dickinson, M.J. Justice, V. Philip, V. Kumar, K.L. Svenson, R.E. Braun, S. Wells, H. Cater, M. Stewart, S. Clementson-Mobbs, R. Joynson, X. Gao, T. Suzuki, S. Wakana, D. Smedley, J.K. Seong, G. Tocchini-Valentini, M. Moore, C. Fletcher, N. Karp, R. Ramirez-Solis, J.K. White, M.H. de Angelis, W. Wurst, S.M. Thomasy, P. Flicek, H. Parkinson, S.D.M. Brown, T.F. Meehan, P.M. Nishina, S.A. Murray, M.P. Krebs, A.M. Mallon, K.C.K. Lloyd, C.J. Murphy, and A. Moshiri, Identification of genes required for eye development by high-throughput screening of mouse knockouts. Commun Biol, 2018. 1: p. 236.
28. Ma, H., C. Liu, B. Shi, Z. Zhang, R. Feng, M. Guo, L. Lu, S. Shi, X. Gao, W. Chen, and L. Sun, Mesenchymal Stem Cells Control Complement C5 Activation by Factor H in Lupus Nephritis. EBioMedicine, 2018. 32: p. 21-30.
29. Luan, X.R., X.L. Chen, Y.X. Tang, J.Y. Zhang, X. Gao, H.P. Ke, Z.Y. Lin, and X.N. Zhang, CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse. Mol Ther Nucleic Acids, 2018. 12: p. 220-228.
30. Lu, K., T.S. Shi, S.Y. Shen, W.L. Lu, J. Wu, K.J. Zhang, X.B. Zhu, Y. Shi, X.L. Liu, F. Yu, L. Li, H.J. Teng, X. Gao, H.X. Ju, W. Wang, C.J. Li, Q. Jiang, and B. Xue, Egr1 deficiency disrupts dynamic equilibrium of chondrocyte extracellular matrix through PPARgamma/RUNX2 signaling pathways. Am J Transl Res, 2018. 10(6): p. 1620-1632.
31. Lu, K., T. Shi, L. Li, K. Zhang, X. Zhu, S. Shen, F. Yu, H. Teng, X. Gao, H. Ju, W. Wang, and Q. Jiang, Zhuangguguanjie formulation protects articular cartilage from degeneration in joint instability-induced murine knee osteoarthritis. Am J Transl Res, 2018. 10(2): p. 411-421.
32. Lin, Z., F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen, J. Li, and X. Gao, Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 2018. 9(1): p. 47.
33. Lai, B., J. Zou, Z. Lin, Z. Qu, A. Song, Y. Xu, and X. Gao, Haploinsufficiency of hnRNP U Changes Activity Pattern and Metabolic Rhythms. Am J Pathol, 2018. 188(1): p. 173-183.
34. Geng, L., S. Wang, X. Li, D. Wang, H. Chen, J. Chen, Y. Sun, W. Chen, G. Yao, X. Gao, W. Chen, S. Shi, X. Feng, and L. Sun, Association between Type I interferon and depletion and dysfunction of endothelial progenitor cells in C57BL/6 mice deficient in both apolipoprotein E and Fas ligand. Curr Res Transl Med, 2018. 66(3): p. 71-82.
35. Geng, L., X. Tang, K. Zhou, D. Wang, S. Wang, G. Yao, W. Chen, X. Gao, W. Chen, S. Shi, N. Shen, X. Feng, and L. Sun, MicroRNA-663 induces immune dysregulation by inhibiting TGF-beta1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Cell Mol Immunol, 2018.
36. Dai, J., S. Zhou, Q. Ge, J. Qin, D. Chen, Z. Xu, D. Shi, J. Li, H. Ju, Y. Cao, M. Zheng, C.J. Li, X. Gao, H. Teng, and Q. Jiang, Bi-directional regulation of cartilage metabolism by inhibiting BET proteins-analysis of the effect of I-BET151 on human chondrocytes and murine joints. J Orthop Surg Res, 2018. 13(1): p. 118.
37. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren, Z. Lin, and X. Gao, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2018.
38. Wang, Q., S. Jiang, A. Song, S. Hou, Q. Wu, L. Qi, and X. Gao, HOXD-AS1 functions as an oncogenic ceRNA to promote NSCLC cell progression by sequestering miR-147a. Onco Targets Ther, 2017. 10: p. 4753-4763.
39. Song, A., S. Jiang, Q. Wang, J. Zou, Z. Lin, and X. Gao, JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function. Endocrinology, 2017. 158(6): p. 1798-1811.
40. Meehan, T.F., N. Conte, D.B. West, J.O. Jacobsen, J. Mason, J. Warren, C.K. Chen, I. Tudose, M. Relac, P. Matthews, N. Karp, L. Santos, T. Fiegel, N. Ring, H. Westerberg, S. Greenaway, D. Sneddon, H. Morgan, G.F. Codner, M.E. Stewart, J. Brown, N. Horner, M. Haendel, N. Washington, C.J. Mungall, C.L. Reynolds, J. Gallegos, V. Gailus-Durner, T. Sorg, G. Pavlovic, L.R. Bower, M. Moore, I. Morse, X. Gao, G.P. Tocchini-Valentini, Y. Obata, S.Y. Cho, J.K. Seong, J. Seavitt, A.L. Beaudet, M.E. Dickinson, Y. Herault, W. Wurst, M.H. de Angelis, K.C.K. Lloyd, A.M. Flenniken, L.M.J. Nutter, S. Newbigging, C. McKerlie, M.J. Justice, S.A. Murray, K.L. Svenson, R.E. Braun, J.K. White, A. Bradley, P. Flicek, S. Wells, W.C. Skarnes, D.J. Adams, H. Parkinson, A.M. Mallon, S.D.M. Brown, and D. Smedley, Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet, 2017. 49(8): p. 1231-1238.
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45. Bowl, M.R., M.M. Simon, N.J. Ingham, S. Greenaway, L. Santos, H. Cater, S. Taylor, J. Mason, N. Kurbatova, S. Pearson, L.R. Bower, D.A. Clary, H. Meziane, P. Reilly, O. Minowa, L. Kelsey, G.P. Tocchini-Valentini, X. Gao, A. Bradley, W.C. Skarnes, M. Moore, A.L. Beaudet, M.J. Justice, J. Seavitt, M.E. Dickinson, W. Wurst, M.H. de Angelis, Y. Herault, S. Wakana, L.M.J. Nutter, A.M. Flenniken, C. McKerlie, S.A. Murray, K.L. Svenson, R.E. Braun, D.B. West, K.C.K. Lloyd, D.J. Adams, J. White, N. Karp, P. Flicek, D. Smedley, T.F. Meehan, H.E. Parkinson, L.M. Teboul, S. Wells, K.P. Steel, A.M. Mallon, and S.D.M. Brown, A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nat Commun, 2017. 8(1): p. 886.
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