个人简历

2008-2013 Sanford-Burnham 医学研究所, USA，博士后，导师：Daniel P. Kelly
2013-2015 副教授, 南京大学模式动物研究所
2015-2018 教授，南京大学模式动物研究所
2018-至今 教授、副所长，南京大学模式动物研究所

研究领域

线粒体重塑与代谢疾病。主要是运用基因工程小鼠为模式动物，通过分子细胞生物学手段探索包括肥胖症、糖尿病与慢性肌肉病在内的代谢疾病发生的分子机制。主要的研究方向有：1）骨骼肌线粒体代谢重塑与疾病的发生；2）利用全基因组染色体状态谱动态分析及代谢组学分析的方法，研究运动代谢的分子基础；3）重要细胞器的交互对话在代谢稳态调节中的作用机制

近期论文

1. Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, XueB, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*.Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis. Proc Natl Acad Sci USA. 2019 May 23. doi: 10.1073/pnas.1814480116.
2. Xu Z, Fu T, Guo Q, Sun W, Gan Z*. Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.Pharmacol Res. 2018; 141:176-180.3. Zhu Z, Wang Z, Zhang C, Wang Y, Zhang H, Gan Z, Guo Z, Wang X. Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism.Chem Sci. 2019; 10(10):3089-3095.
4. Gan Z*, Fu T, Kelly DP*, Vega RB*. Skeletal muscle mitochondrial remodeling in exercise and diseases. Cell Research.2018; 28(10): 969-980.
5. Fu T, Xu Z, Lin L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu M, Chen Q*, Gan Z*. Mitophagy directs muscle-adipose dialogue to alleviate dietary obesity. Cell Reports. 2018; 23: 1357–1372.
6. Ma Y, Sun L, Li J, Hu Y, Gan Z, Zong G, Zheng H, Jin Q, Li H, Hu FB, Zeng R, Sun Q, Lin X. Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese.2019; 60(2):421-429.
7. Yang J, Cao Q, Zhang H, Hao L, Zhou D, Gan Z, Li Z, Tong YX, Ji LN, Mao ZW. Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium (I)-DCA conjugate.Biomaterials.2018; 176:94-105. 8. Yang J, Zhao JX, Cao Q, Hao L, Zhou D, Gan Z, Ji LN, Mao ZW.Simultaneously Inducing and Tracking Cancer Cell Metabolism Repression by Mitochondria-Immobilized Rhenium (I) Complex.ACS Appl Mater Interfaces.2017; 9(16):13900-13912. 9. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega R, Zhu MS, Kelly DP, Gao X, Gan Z*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med.2016; 8(10):1212-1228. Cover story.
10. Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Lai L, Kong Y, Xie H, Yi F, Lai L, Vega R, Kelly DP, Smith SR, Gan Z*. Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle. J. Biol. Chem. 2016; 291(49):25306-25318.
11. Kong Y*, Li K, Fu T, Wan C, Zhang D, Song H, Zhang Y, Liu N, Gan Z*, Yuan L*. Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression.Oncotarget. 2016; 7(42):67716-67731.