个人简历

2018-至今，教授, 南京大学生命科学学院
2015-2018，讲师，哈佛大学医学院
2010-2015，博后，哈佛大学医学院

研究领域

蛋白质化学

近期论文

1. Feng J.*, Dong X.*, Pinello J.F.*,Zhang J.*, Lu C., Iacob R.E., Engen J.R., Snell W.J., Springer T.A. (2018) Fusion surface structure, function, and dynamics of gamete fusogen HAP2. Elife. 2018, 7, e39772
2. Dong X.*, Zhao B.*, Lin F. Lu C., Roger B.N., Springer T.A. (2018) High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate.Proc Natl Acad Sci 115(7), E1429-E1436
3. Zhao B., Xu S, Dong X., Lu C., Springer T.A. (2018) Prodomain-Growth Factor Swapping in the Structure of pro-TGF-β1. J. Biol. Chem. Journal of Biological Chemistry293 (5), 1579-1589
4. Dong X.*, Zhao B.*, Iacob R.E., Zhu J., Koksal A.C., Lu C., Engen J.R., Springer T.A. (2017) Force Interacts with Macromolecular Structure in Activation of TGF-b. Nature542, 55-59
5. Kotecha A., Wang Q., Dong X., Ilca S., Ondiviela M., Rao Z., Seago J., Charleston B., Fry E., Abrescia N., Springer A. *, Huiskonen J. *, Stuart D.*Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus. Nature communication. 2017
6. Wang J,Dong X., Zhao B., Li J., Lu C., Springer T.A.* Atypical Interactions of Integrin αvβ8 with pro-TGF-β1, Proc Natl Acad Sci, 2017,
7. Dong X., Hudson N., Lu C., Springer T.A. (2014)Structural determinants of integrin β-subunit specificity for latent TGF-β. Nat. Struct. & Mol. Biol.21 (12), 1091-1096
8. Blenner M.A., Dong X., Springer T.A. (2014) Towards the structural basis of regulation by force of von Willebrand factor binding to Glycoprotein Ib. J. Biol. Chem.289, 5565-5579
9. Dong X.,Mi L., Zhu J., Wang W., Hu P., Luo B. H., Springer T.A. (2012) αVβ3 Integrin crystal structures and their functional implications.Biochemistry51, 8814-8828
10. Wang R., Zhu J., Dong X., Shi M., Lu C., Springer T.A. (2012) GARP regulates the bioavailability and activation of TGF-β. Mol. Biol. Cell.23, 1129-1139
11. Chen H., Dong X., Zhou M., Shi H., Luo X. (2011) Docking-based virtual screening of potential human P2Y12 receptor antagonists. Acta. Biochim. Biophys. Sin. 43, 400-408.
12. Zhou M.*, Dong X.*, Baldauf C., Chen H., Zhou Y., Springer T.A., Lu X., Zhong, C., Grater, F., Ding, J. (2011) A novel calcium-binding site of von Willebrand factor A2 domain
regulates its cleavage by ADAMTS13. Blood.117, 4623-4631.
13. Zhou B., Wang S., Xu L.X., Meng F.L., Xuan Y.J., Duan Y.M., Wang J.Y., Hu H., Dong X., Ding J., Zhou J.Q. (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol. Cell. Biol.30, 2391-2400.
14. Zhou M.*, Dong X.*, Shen N., Zhong C., Ding J. (2010) Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design. Nucleic Acids Res.38, 3399-3413.