个人简历

2010.08-至今，主任, 南京大学江苏小核酸工程技术研究中心
2006.09-至今，教授, 南京大学生命科学学院
2004.09-2006.08，助理教授, 医学院, Emory University, USA
1999.05-2004.08，讲师（Instructor）, 医学院, Emory University, USA
1994.01-1999.03，Research Associate, 医学院, University of Pennsylvania, USA

研究领域

天然免疫与炎症
microRNA与免疫

近期论文

1. Zen K*, Guo Y, Bian Z, Lv Z, Zhu D, Ohnishi H, Matozaki T, Liu Y. (2013) Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state. Nat Commun. 4:2436.
2. Zhu D, Pan C, Li L, Bian Z, Lv Z, Shi L, Zhang J, Li D, Gu H, Zhang CY, Liu Y, Zen K*. (2013) MicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal- regulatory protein α. J Allergy Clin Immunol. 132(2):426-36.e8.
3. Li L, Zhang T, Diao, W , Jin F, Shi L, Meng J, Liu H, Zhang J, Zeng C, Zhang M, Liang S, Liu Y, Zhang CY, Liu ZH, and Zen K*. (2015) Role of myeloid-derived suppressor cells in glucocorticoid-mediated amelioration of focal segmental glomerulosclerosis. J Am Soc Nephrol. pii: ASN.2014050468.
4. Zen K*, Guo YL, Li LM, Bian Z, Zhang CY, Liu Y. (2011) Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood. 117(18):4885-94.
5. Tang R, Li L, Zhu D, Hou D, Cao T, Gu H, Zhang J, Chen J, Zhang CY, Zen K*. (2011) Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system. Cell Res. 22(3):504-15.
6. Li LM, Hu ZB, Zhou ZX, Chen X, Liu FY, Zhang JF, Shen HB, Zhang CY, and Zen K*. (2010) Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res. 70(23):9798-807.
7. Zhang Y, Li L, Yu J, Zhu D, Zhang Y, Li X, Gu H, Zhang CY, Zen K* (2014) Microvesicle-mediated delivery of transforming growth factor β1 siRNA for the suppression of tumor growth in mice. Biomaterials. 2014 Feb 21. [Epub ahead of print]
8. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K*, and Zhang CY. (2010) Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 39(1):133-44.
9. Bian Z, Li LM, Tang R, Hou DX, Chen X, Zhang CY, and Zen K*. (2010). Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Cell Res. 20(9):1076-8.
10. Zhou Z, Li X, Liu J, Dong L, Chen Q, Liu J, Kong H, Zhang Q, Qi X, Hou D, Zhang L, Zhang G, Liu Y, Zhang Y, Li J, Wang J, Chen X, Wang H, Zhang J, Chen H, Zen K*, Zhang CY. (2014) Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Cell Res. doi: 10.1038/cr.2014.130.
11. Yin Y, Cai X, Chen X, Liang H, Zhang Y, Li J, Wang Z, Chen X, Zhang W, Yokoyama S, Wang C, Li L, Li L, Hou D, Dong L, Xu T, Hiroi T, Yang F, Ji H, Zhang J, Zen K*, Zhang CY. (2014) Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Res. 24(10):1164-80.
12. Zhang L, Hou D, Chen X, Li D, Zhu L, Zhang Y, Li J, Bian Z, Liang X, Cai X, Yin Y, Wang C, Zhang T, Zhu D, Zhang D, Xu J, Chen Q, Ba Y, Liu J, Wang Q, Chen J, Wang J, Wang M, Zhang Q, Zhang J, Zen K*, Zhang CY. (2012) Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 22(1):107-26.
13. Chen X, Gao C, Li H, Huang L, Sun Q, Dong Y, Tian C, Gao S, Dong H, Guan D, Hu X, Zhao S, Li L, Zhu L, Yan Q, Zhang J, Zen K*, and Zhang CY. (2010). Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products. Cell Res. 20(10):1128-37.
14. Bian Z, Li L, Cui J, Zhang H, Liu Y, Zhang CY, Zen K*. (2011）Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis. J Pathol. 225(4):544-53.
15. Zhang J, Li L, Li J, Liu Y, Zhang CY, Zhang Y, Zen K*. (2014) Protein Tyrosine Phosphatase 1B Impairs Diabetic Wound Healing Through Vascular Endothelial Growth Factor Receptor 2 Dephosphorylation. Arterioscler Thromb Vasc Biol. pii: ATVBAHA.114.304705.
16. Liu DQ, Guo YL, Bian Z, Chen YY, Chen X, Liu Y, Zhang CY, and Zen K*. (2010). Uncoupling Protein-2 Negatively Regulates Polymorphonuclear Leukocytes Chemotaxis via Modulating [Ca2+] Influx. Arterioscler Thromb Vasc Biol. 30(3):575-81.
17. Cai X, Yin Y, Li N, Zhu D, Zhang J, Zhang CY, Zen K*. (2012) Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155. J Mol Cell Biol. 4(5):341-3.
18. Zhang T, Yu J, Zhang Y, Li L, Chen Y, Li D, Liu F, Zhang CY, Gu H, Zen K*. (2014) Salmonella enterica serovar Enteritidis modulates intestinal epithelial miR-128 levels to decrease macrophage recruitment via M-CSF. J Infect Dis. [Epub ahead of print]
19. Li L, Zhang J, Diao W, Wang D, Wei Y, Zhang CY, Zen K*. (2014) MicroRNA-155 and MicroRNA-21 Promote the Expansion of Functional Myeloid-Derived Suppressor Cells. J Immunol. 192(3):1034-43.
20. Pan Y, Liang H, Liu H, Li D, Chen X, Li L, Zhang CY, Zen K*. (2014) Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor. J Immunol. 192(1):437-46.