个人简历

叶岚，南京医科大学特聘教授。2009年于香港中文大学生物化学系博士学位，2009年-2013年美国宾夕法尼亚大学医学院糖尿病和代谢系博士后，主要从事研究表观遗传、代谢性疾病与雄性不育的关联性以及乳腺癌疾病发病机制及其治疗。2013年南京医科大学生殖医学国家重点实验室教授。研究成果在Science, Cell Res, Front Genet和J Clin Invest等国际杂志上发表。

承担项目
1.“江苏省高层次创新创业团队”核心成员，项目起止年月2016-2018，正在进行；
2.“Rapamycin调控精子发生机制及临床相关性研究”，江苏省高校自然科学重大项目，批准号15KJA180006，项目起止年月2015.7-2018.6，项目负责人；
3.“Rapamycin引起雄性不育和mTOR信号通路调控精子发生的分子机制研究”，国家自然科学基金面上项目，批准号81471502，项目起止年月2015.1-2018.12，项目负责人；

研究领域

配子发生、表观遗传
乳腺癌发生机制""

近期论文

1. Yue Zhang, Rui Guo, Yiqiang Cui, Zhiping Zhu, Yingwen Zhang, Hao Wu, Bo Zheng, Qiuling Yue, Shun Bai, Wentao Zeng, Xuejiang Guo,Zuomin Zhou, Bin Shen, Ke Zheng, Mingxi Liu#, Lan Ye#, Jiahao Sha#. An essential role for PNLDC1 in piRNA 3′ end trimming and male fertility in mice. Cell Res, 2017, 27(11): cr2017125.
2. Mengneng Xiong, Zhiping Zhu, Suwen Tian, Ruping Zhu,Shun Bai, Kaiqiang Fu, James G. Davis, Zheng Sun,Joseph A. Baur, Ke Zheng, Lan Ye#. Conditional ablation of Raptor in the male germline causes infertility due to meiotic arrest and impaired inactivation of sex chromosomes. FASEB J. May 2017.
3. Dudley W Lamming#, Lan Ye#, PekkaKatajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima, David A Guertin, David M Sabatini, Joseph A Baur: Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science, Mar 2012, 335(6076): 1638-43.
4. Dudley W. Lamming, Lan Ye, David M. Sabatini, and Joseph A. Baur: Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Invest, 2013 Mar, 123(3):980-9.
5. Lan Ye#, Wai M. Gho, Franky L. Chan, Shiuan Chen, Lai K. Leung. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase.
Int J Cancer, Mar 2009, 124(5):1028-36.