个人简历

高隽博士，2013年国家自然基金优秀青年基金获得者，2004年7月获中国科学技术大学博士学位，同年进入中国科学院上海神经科学研究所从事博士后工作，2006年出站后被南京大学模式动物研究所应聘为副教授、研究员。2013年9月被南京医科大学聘为教授和博士生导师，神经生物学学系主任和学科带头人。相关研究成果发表在Nature、NatureNeuroscience、Neuron、PNAS等国际权威期刊上。历年来，主持国家自然科学基金优秀青年基金项目1项、面上项目1项、青年基金项目1项。主要学术兼职：美国神经学会会员，中国神经学会会员，江苏省细胞和发育生物学学会理事。

研究领域

神经精神疾病以及学习记忆损伤机制的研究

近期论文

近期的代表性论文（*通讯作者）
1.TianT,ZhangHX,HeCP,FanS,ZhuYL,QiC,HuangNP,XiaoZD,LuZH,TannousBA,GaoJ*(2018)SurfaceFunctionalizedExosomesasTargetedDrugDeliveryVehiclesforCerebralIschemiaTherapy.Biomaterials.150:137-149
2.XuM,HanXN,LiuR,LiYJ,QiC,YangZZ,ZhaoCJ*,GaoJ*(2018)PDK1DeficitImpairstheDevelopmentoftheDentateGyrusinMice.CerebralCortex.Feb6
3.YangJJ,LaiBB,XuAL,LiuY,LiXM,ZhaoYN,LiWF,JiMH,HuG,GaoX,GaoJ*(2014)Maged1co-interactingwithCREBthroughahexapeptiderepeatdomainregulateslearningandmemoryinmice.MolecularNeurobiology.51(1):8-18
4.GaoJ,WangWY,MaoYW,Gr?ffJ,GuanJS,PanL,MakG,KimD,SuSC,TsaiLH(2010)AnovelpathwayregulatesmemoryandplasticityviaSIRT1andmiR-134.Nature.466:1105-9
5.ZhaoYN,LiWF,LiF,ZhangZ,DaiYD,XuAL,QiC,GaoJM,GaoJ*(2013)ResveratrolimproveslearningandmemoryinnormallyagedmicethroughmicroRNA-CREBpathway.BiochemBiophysResCommun.435:597-602
6.GaoJ,DuanB,WangDG,DengXH,ZhangGYXuLandXuTL(2005)CouplingbetweenNMDAReceptorandAcid-SensingIonChannelContributestoIschemicNeuronalDeath.Neuron,48:635-646
7.DobbinMM,MadabhushiR,PanL,ChenY,KimD,GaoJ,AhanonuB,PaoPC,QiuY,ZhaoY,TsaiLH(2013)SIRT1collaborateswithATMandHDAC1tomaintaingenomicstabilityinneurons.NatureNeuroscience16:1008-15
8.Gr?ffJ,GaoJ,KahnM,SamieiA,OtaKT,ReiD,andTsaiLH(2012)SIRT1activationasacaloricrestriction-mimetictodelaytheonsetofneurodegeneration.JNeurosci.33:8951-60
9.Giusti-RodríguezP,GaoJ,Gr?ffJ,ReiD,SodaT,TsaiLH(2011)SynapticDeficitsAreRescuedinthep25/Cdk5ModelofNeurodegenerationbytheReductionofβ-Secretase(BACE1).JNeurosci.31:15751-6
10.GuanJS,SuSC,GaoJ,JosephN,XieZ,ZhouY,DurakO,ZhangL,ZhuJJ,ClauserKR,CarrSA,TsaiLH(2011)Cdk5isrequiredformemoryfunctionandhippocampalplasticityviathecAMPsignalingpathway.PLoSOne.6:e25735
11.YeJH,XuYJ,GaoJ,YanSG,ZhaoJ,TuQ,ZhangJ,DuanXJ,SommerCA,MostoslavskyG,KaplanDL,WuYN,ZhangCP,WangL,ChenJ(2011).Critical-sizecalvarialbonedefectshealinginamousemodelwithsilkscaffoldsandSATB2-modifiediPSCs.Biomaterials.32:5065-76
12.SchwerB,SchumacherB,LombardDB,XiaoC,KurtevMV,GaoJ,SchneiderJI,ChaiH,BronsonRT,TsaiLH,DengCX,AltFW(2010)Neuralsirtuin6(Sirt6)ablationattenuatessomaticgrowthandcausesobesity.ProcNatlAcadSciUSA.107:21790-4
13.GuanJS,HaggartySJ,GiacomettiE,DannenbergJ,JosephN,GaoJ,NielandTJF,ZhouY,WangX,MazitschekR,BradnerJE,DePinhoRA,JaenischR&TsaiLH(2009)HDAC2negativelyregulatesmemoryformationandsynapticplasticity.Nature.459:55-63