郭兴
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个人简历
郭兴博士,男,1983年出生,籍贯山西省太原市。博士研究生毕业于北京协和医学院遗传学专业目前主持国家自然科学基金面上项目1项,蛋白质组学国家重点实验室开放课题1项。在SCI收录期刊杂志上发表文章7篇,代表性论文发表在JCI、NatureCommunications等专业高水平杂志上。近年承担课题情况国家自然科学基金面上项目(项目批准号:31472326),剪接因子SFRS5的泛素化和乙酰化修饰调控研究,2015.01-2018.12,80万元,主持。研究领域
研究方向:(1)线粒体功能紊乱与神经退行性疾病之间的关联(2)线粒体质量控制的分子机制近期论文
代表性论文:1.GuoX,SunXY,HuD,ZhangRL,WangYJ,FujiokaH,LuoY,andQiX,VCPrecruitmenttomitochondriabymutantHuntingtincausesmitophagyimpairmentandneurodegenerationinmodelsofHuntington'sdisease,NatCommun,2016Aug26;7:12646.PMID:275616802.GuoX,DisatnikMH,MonbureauM,ShamlooM,Mochly-RosenDandQiX,InhibitionofmitochondrialfragmentationdiminishesHuntington’sdisease-associatedneurodegeneration.JClinInvest,2013Dec2;123(12):5371-88.PMID:24231356.3.GuoXandQiX,VCPcooperateswithUBXD1todegrademitochondrialoutermembraneproteinMCL1undertheconditionsassociatedwithHuntington'sdisease.BBA-MolecularBasisofDisease,2017Feb;1863(2):552-559.PMID:279132124.GuoX,SesakiHandQiX,Drp1stabilizesp53onthemitochondriatotriggernecrosisunderoxidativestressconditionsinvitroandinvivo.BiochemJ,2014Jul1;461(1):137-46.PMID:24758576.(HighlightedbyBiochemJviapodcast,2014Jul)5.SuYC,GuoXandQiX,Threonine56phosphorylationofBcl-2isrequiredforLRRK2G2019S-inducedmitochondrialdepolarizationandautophagy.BBA-MolecularBasisofDisease,2015Jan,1852(1):12-21(Co-firstauthor)PMID:254469916.GuoX,ShenS,SongSS,HeS,CuiY,XingGC,WangJ,FanLB,HeFC,ZhangLQ.TheE3ligaseSmurf1regulatesWolframsyndromeproteinstabilityattheendoplasmicreticulum.J.Biol.Chem.2011,286(20):18037-18047.PMID:214546197.LuoX,WuJ,LiY,NanZ,GuoX,WangY,ZhangA,WangZ,XiaG,TianY.SynergisticEffectsofGhSOD1andGhCAT1OverexpressioninCottonChloroplastsonEnhancingTolerancetoMethylViologenandSaltStresses.Plosone.2013Jan15;8(1):1-11.PMID:23335985 相关热点
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