个人简历

陈允梓，男，博士，教授，2005年于南京大学获得生物化学与分子生物学博士学位。曾在J.Clin.Invest.，J.Immunol.，J.Bio.Chem.，Inflamm.BowelDis.等国际著名期刊上发表SCI科研论文20多篇，承担一项国家自然科学基金面上项目（在研）。
研究基金和课题：
《维生素D及其受体(VitaminD/VDR)在内毒素耐受中的作用及机制研究》国家自然科学基金（81371759），70万，2014-2018（主持）

研究领域

营养与免疫性疾病

近期论文

代表性成果：
1.DuJ,ChenY*,ShiY,LiuT,CaoY,TangY,GeX,NieH,ZhengC,LiYC.1,25-DihydroxyvitaminDProtectsIntestinalEpithelialBarrierbyRegulatingtheMyosinLightChainKinaseSignalingPathway.InflammBowelDis.2015Aug17.*Co-correspondingauthor
2.LiYC,ChenY,DuJ.CriticalrolesofintestinalepithelialvitaminDreceptorsignalingincontrollinggutmucosalinflammation.JSteroidBiochemMolBiol.2015Apr;148:179-83
3.ChenY*,DuJ,ZhangZ,LiuT,ShiY,GeX,LiYC.MicroRNA-346MediatesTumorNecrosisFactorα-InducedDownregulationofGutEpithelialVitaminDReceptorinInflammatoryBowelDiseases.InflammBowelDis.2014Nov;20(11):1910-8*Co-correspondingauthor
4.LiYC,ChenY,LiuW,ThadhaniR.MicroRNA-mediatedmechanismofvitaminDregulationofinnateimmuneresponse.JSteroidBiochemMolBiol.2014Oct;144PtA:81-6
5.LiuW*,ChenY*,GolanM.A.,AnnunziataM.L.,DuJ,DoughertyU.,KongJ,MuschM.,HuangY,PekowJ.,ZhengC,BissonnetteM.,HanauerS.B.,LiYCIntestinalepithelialvitaminDreceptorsignalinginhibitsexperimentalcolitis.JClin.Invest.2013,123(9):3983-3996.
*Co-firstauthorsequallycontributedtothework
6.ChenY,LiuW,SunT,HuangY,WangY,DebD.K.,YoonD,KongJ,ThadhaniR.,LiYC1,25-DihydroxyvitaminDpromotesnegativefeedbackregulationofTLRsignalingviatargetingmicroRNA-155-SOCS1inmacrophages.JImmunol.2013,190(7):3687-3695.
7.ChenY,ZhangJ,GeX,DuJ,DebD.K.,LiYCVitaminDreceptorinhibitsnuclearfactorκBactivationbyinteractingwithIκBkinaseβprotein.JBiol.Chem.2013,288(27):19450-19458.
8.KongJ,ChenY,ZhuG,ZhaoQ,LiYC.1,25-DihydroxyvitaminD3upregulatesleptinexpressioninmouseadiposetissue.JEndocrinol.2013,216(2):265-271.
9.WangY,DebD.K.,ZhangZ,SunT,LiuW,YoonD.,KongJ,ChenY,ChangA,LiYCVitaminDreceptorsignalinginpodocytesprotectsagainstdiabeticnephropathy.JAm.Soc.Nephrol.2012,23(12):1977-1986.
10.DebD.K.,WangY,ZhangZ,NieH.,HuangX,YuanZ,ChenY,ZhaoQ,LiYCMolecularmechanismunderlying1,25-dihydroxyvitaminDregulationofnephringeneexpression.JBiol.Chem.2011,286(37):32011-32017.
11.ChenY,KongJ,SunT,LiG,SzetoF.L.,LiuW,DebD.K.,WangY,ZhaoQ,ThadhaniR.,LiYC1,25-DihydroxyvitaminD₃suppressesinflammation-inducedexpressionofplasminogenactivatorinhibitor-1byblockingnuclearfactor-κBactivation.Arch.Biochem.Biophys.2011,507(2):241-247.
12.ZhangJ,ChenY,HuangQ,ChengW,KangY,ShuL,YinW,HuaZCNuclearlocalizationofc-FLIP-LanditsregulationofAP-1activity.Int.JBiochem.CellBiol.2009,41(8-9):1678-1684.
13.ZhangY,DebD.K.,KongJ,NingG,WangY,LiG,ChenY,ZhangZ,StrugnellS.,SabbaghY.,ArbeenyC.,LiYCLongtermtherapeuticeffectofvitaminDanalogdoxercalciferolondiabeticnephropathy:strongsynergismwithAT1receptorantagonist.Am.JPhysiol.Renal.Physiol.2009,297(3):F791-801.
14.DebD.K.,ChenY,ZhangZ,ZhangY,SzetoF.L.,WongK.E.,KongJ,LiYC.1,25-DihydroxyvitaminD3suppresseshighglucose-inducedangiotensinogenexpressioninkidneycellsbyblockingtheNF-{kappa}Bpathway.Am.JPhysiol.Renal.Physiol.2009,296(5):F1212-1218.