个人简历

段晓品，女，博士生导师，中国抗癌协会纳米肿瘤学专业委员会委员。2008年在河北大学药学院获取学士学位，2013年以沈阳药科大学与上海药物研究所联合培养的方式获博士学位，之后进入美国芝加哥大学进行主要研究方向为新型纳米制剂用于肿瘤免疫治疗及体内肿瘤/免疫细胞示踪。迄今为止共发表SCI论文22篇，5篇入选为ESI“高被引论文”，第一作者或共同第一作者15篇，其中IF>10论文8篇，包括J. Am. Chem. Soc.，ACS Nano，Angew. Chem. Int. Ed.，Nat. Commun.，Small，Biomaterials。获授权中国发明专利1项，申请PCT专利1项，研发的两款药物制剂正在美国进行I期临床试验。
获得奖励：
ACS-Yao Yuan Award of Medicinal Chemistry （2017）
中国药学会科技奖一等奖（2015）
康缘药业奖学金（2012）
卡乐康奖学金（2010）
专利
1. 李亚平，段晓品，肖计生，顾王文，张志文。一种用作非病毒基因载体的两亲性梳状SMA-PEI接枝共聚物及其制备方法和用途。中国科学院上海药物研究所，专利号：201210102333.6
2. W. Lin, X. Duan, C. Chan, W. Han, C. He. Nanoparticles for Chemotherapy, Targeted Therapy, Photodynamic Therapy, Immunotherapy, and Any Combination Thereof. Application No. PCT/US2017/033822, Publication No. WO/2017/201528
主持课题（包括教学、科研）：
序号
课题名称
项目来源
资助金额
起止年份
1
新型纳米制剂用于肿瘤综合治疗及诊断
高水平大学建设-引进高层次人才科研经费
300万
2018-2021
2
靶向NF-kB信号通路的智能纳米制剂用于结直肠癌联合免疫治疗的研究
广州市科学技术局
20万
2020-2023

研究领域

1. 新型纳米制剂用于肿瘤免疫治疗2. 新型纳米制剂用于体内肿瘤/免疫细胞示踪

近期论文

代表性论文/著作（包括教学、科研）：
Xiaopin Duan#, Christina Chan#, Wenbo Han#, Nining Guo, Ralph R Weichselbaum, Wenbin Lin*, Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors. Nat Commun. 2019, 10: 1899
Xiaopin Duan#, Christina Chan#, Wenbin Lin*, Nanoparticle-mediated immunogenic cell death enables and potentiates cancer immunotherapy. Angew. Chem. Int. Ed. 2019, 58: 670-680.
Xiaopin Duan, Christina Chan, Nining Guo, Wenbo Han, Ralph R Weichselbaum, Wenbin Lin*, Photodynamic therapy mediated by nontoxic core-shell nanoparticles synergize with immune checkpoint blockade to elicit antitumor immunity and antimetastatic effect on breast cancer. J. Am. Chem. Soc. 2016, 138: 16686-16695.
Chunbai He#, Xiaopin Duan#, Nining Guo#, Christina Chan, Christopher Poon, Ralph R Weichselbaum, Wenbin Lin*, Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy. Nat. Commun. 2016, 7: 12499.
Xiaopin Duan, Demin Liu, Christina Chan, Wenbin Lin*, Polymeric Micelle-Mediated Delivery of DNA-Targeting Organometallic Complexes for Resistant Ovarian Cancer Treatment. Small 2015, 11: 3962-3972.
Zhi-Ming Zhang#, Xiaopin Duan#, Shuang Yao, Zhishu Wang, Zekai Lin, Yang-Guang Li, La-Sheng Long, En-Bo Wang*, Wenbin Lin*, Cation-mediated optical resolution and anticancer activity of chiral polyoxometalates built from entirely achiral building blocks. Chem. Sci. 2016, 7: 4220-4229.
Xiaopin Duan, Chunbai He, Steven J. Kron, Wenbin Lin*, Nanoparticle formulations of cisplatin for cancer therapy. WIRES Nanomed. Nanobi. 2016, 8: 776-791.
Christopher Poon#, Xiaopin Duan#, Christina Chan, Wenbo Han, Wenbin Lin*, Nanoscale coordination polymers codeliver carboplatin and gemcitabine for highly effective treatment of platinum-resistant ovarian cancer. Mol. Pharma. 2016, 13: 3665-3675.
Xiaopin Duan#, Jisheng Xiao#, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*, Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram. ACS Nano 2013, 7: 5858-5869.
Jisheng Xiao#, Xiaopin Duan#, Qingshuo Meng, Qi Yin, Zhiwen Zhang, Haijun Yu, Lingli Chen, Wangwen Gu, Yaping Li*, Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis. Acta Biomater. 2014, 10: 2674-2683.
Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao, Yaping Li*, Multi-targeted inhibition of tumor growth and metastasis by disulfiram-loaded redox-sensitive shell crosslinked micelles. Nanotechnology 2014, 25: 125102.
Jisheng Xiao#, Xiaopin Duan#, Qi Yin, Zhiwen Zhang, Haijun Yu, Yaping Li*, Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer. Biomaterials 2013, 34: 9648-9656.
Jisheng Xiao, Xiaopin Duan, Qi Yin, Zehong Miao*, Haijun Yu, Chunying Chen, Zhiwen Zhang*, Jun Wang, Yaping Li*, The inhibition of metastasis and growth of breast cancer by blocking the NF-kB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles. Biomaterials 2013, 34: 5381-5390.
Xiaopin Duan, Yaping Li*, Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking. Small 2013, 9: 1521-1532.
Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Shirui Mao*, Yaping Li*, Amphiphilic graft copolymer based on poly(styrene-co-maleic anhydride) with low molecular weight polyethylenimine for efficient gene delivery. Int. J. Nanomed. 2012, 7: 4961-4972.
Jisheng Xiao, Xiaopin Duan, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*, Low molecular weight polyethylenimine-graft-tween 85 for effective gene delivery: synthesis and in vitro characteristics. Bioconjugate Chem. 2011, 23: 222-231.
Xiaopin Duan, Shirui Mao*, New strategies to improve the intranasal absorption of insulin. Drug Discov. Today 2010, 15: 416-427.
Kaiyuan Ni#, Guangxu Lan#, Samuel S Veroneau, Xiaopin Duan, Yang Song, Wenbin Lin*, Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy. Nat. Commun. 2018, 9: 4321
Ruoyu Xu#, Youfu Wang#, Xiaopin Duan, Kuangda Lu, Daniel Micheroni, Aiguo Hu, Wenbin Lin*, Nanoscale metal–organic frameworks for ratiometric oxygen sensing in live cells. J. Am. Chem. Soc. 2016, 138: 2158–2161
Christina Chan#, Nining Guo#, Xiaopin Duan, Wenbo Han, Lai Xue, Darren Bryan, Sean C Wightman, Nikolai N Khodarev, Ralph R Weichselbaum, Wenbin Lin*, Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer, Biomaterials 2019, 210: 94-104
Kaiyuan Ni#, Guangxu Lan#, Christina Chan, Xiaopin Duan, Nining Guo, Samuel S Veroneau, Ralph R Weichselbaum, Wenbin Lin*, Ultrathin Metal-Organic-Layer Mediated Radiotherapy-Radiodynamic Therapy, Matter 2019, in press (https://doi.org/10.1016/j.matt.2019.06.007).
中国抗癌协会纳米肿瘤学专业委员会委员