个人简历

工作经历
2019.08–至今，南方科技大学生物系，助理教授
2015–2019，英国约翰英纳斯中心，博士后
2015，澳门科技大学中药质量控制国家重点实验室，博士后

学习经历
2010-2014，澳大利亚阿德莱德大学，博士
2009-2010，华南理工大学，硕士研究生
2005-2009，华南农业大学，学士

研究领域

天然产物生物合成途径发现与解析
植物功能基因组学和代谢组学
合成生物学和代谢工程
酶学催化反应机理和酶工程改造
小分子化合物介导的植物-微生物互作

近期论文

1.Huang, A.C.#; Jiang, T.#; Liu, Y.X.; Bai, Y.C.; Reed, J.; Qu, B; Goossens, A.; Nutzmann, H.-W.; Bai, Y.; Osbourn, A. A specialized metabolic network selectively modulates Arabidopsis root microbiota. Science, 2019, 364(6440): eaau6389. (# Co-first author)
2.Huang, A.C., Osbourn, A. Plant terpenes that mediate below‐ground interactions: prospects for bioengineering terpenoids for plant protection. Pest Management Science, 2019, DOI:10.1002/ps.5410.
3.Huang, A.C.; Hong, Y. J.; Bond, A. D.; Tantillo, D. J.; Osbourn, A. Diverged terpene synthases reroute the carbocation cyclization path towards the formation of unprecedented 6/11/5 and 6/6/7/5 sesterterpene scaffolds. Angewandte Chemie International Edition, 2018, 57(5), 1291-1295.
4.Huang, A.C.; Kautsar S. A..; Hong, Y. J.; Bond, A. D.; Madema M. H.; Tantillo, D. J.; Osbourn, A. Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveal convergent evolution. Proceedings of the National Academy of Science, U.S.A., 2017, 114(29), E6005-6014.
5.Huang, A.-C.; Sefton, M. A.; Sumby, C. J.; Tiekink, E. R.T.; Taylor, D. K. Mechanistic studies on the autoxidation of a-guaiene: The structural diversity of the sesquiterpenoid downstream products. Journal of Natural Products, 2015, 78, 131-145.
6.Huang, A.-C.; Sefton, M. A.; Taylor, D. K. Comparison of the formation of peppery and woody sesquiterpenes derived from a-guaiene and a-bulnesene under aerial oxidative conditions. Journal of Agricultural and Food Chemistry, 2015, 63(8), 2137-2144
7.Huang, A.-C.; Sumby, C. J.; Tiekink, E. R.T.; Taylor, D. K. Synthesis of guaia-4(5)-en-11-ol, guaia-5(6)-en-11-ol, aciphyllene, 1-epi-melicodenone C and E and other guaiane-type sesquiterpenoids via the diastereoselective epoxidation of guaiol. Journal of Natural Products, 2014, 77(11), 2522-2536.
8.Huang, A.-C.; Burrett, S.; Sefton, M. A.; Taylor, D. K. Production of the pepper aroma compound, (-)-rotundone by aerial oxidation of α-guaiene. Journal of Agricultural and Food Chemistry, 2014, 62 (44), 10809–10815.
9.Huang, A.-C.; Wilde, A.; Ebmeyer, J.; Skouroumounis, G. K.; Taylor, D. K. Examination of the phenolic profile and antioxidant activity of the leaves of the Australian native plant Smilax glyciphylla. Journal of Natural Products, 2013, 76 (10), 1930-1936.
10.Xue Z.; Tan Z.; Huang A.; Zhou Y.; Sun J.; Wang X.; Thimmappa R. B.; Stephenson M. J.; Osbourn A.; Qi X. Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species. New Phytologist. 2018, 218(3):1076-1088.
11.Owen C.; Patron N. J.; Huang A.; Osbourn A. Harnessing plant metabolic diversity. Current Opinion in Chemical Biology, 2017, 40, 24-30.
12.Nützmann H.-W.; Huang A.; Osbourn A. Plant metabolic clusters-from genetics to genomics. New Phytologist. 2016, 211(3), 711-789.
13.Davies, C; Böttcher, C; Nicholson, E. L.; Burbidge, C. A.; Bastian, S; Harvey, K. E.; Huang, A.-C.; Taylor, D. K.; Boss, P. K. Shiraz wines made from grape berries (Vitis vinifera) delayed in ripening by plant growth regulator treatment have elevated rotundone levels and ‘pepper’ flavor and aroma. Journal of Agricultural and Food Chemistry, 2015, 63(8), 2137-2144.