个人简历

教育背景
2008 – 2013 新加坡南洋理工大学 生命科学学院 生物化学博士
2003 – 2006 马来西亚沙巴大学 科学技术学院 理学学士BSc (Hons)
工作经历
2018 – 至今 南方科技大学生物医学工程系 助理教授
2014 – 2018 新加坡国立大学杨潞龄医学院合成生物学临床和技术创新中心（SynCTI） 研究员、治疗研究组长
2013 – 2013 新加坡南洋理工大学化学和生物医学工程学院 项目主管
2012 – 2013 新加坡南洋理工大学生命科学学院 项目主管

研究领域

主要集中在利用合成生物学和蛋白质工程来解决各种健康和环境问题，包括建立一个可以使研究人员共享并系统地收集用于蛋白质工程目的基因结构的平台。2013年获得新加坡南洋理工大学生物化学博士学位，师从Liang Zhao-xun教授，从事利用多模块聚酮合酶酶法生产次级代谢产物，和设计蛋白质作为生物传感器用于追踪细菌胞内信号分子cyclic di-GMP内在水平的科学研究

近期论文

1. Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, Yew WS, Thiery JP, Chang MW. Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention. Nature Biomedical Engineering, 2018, 2, 27-37
2. Lubkowicz D*, Ho CL*, Lee YS, Chang MW. Reprogramming probiotic Lactobacillus reuteri as a biosensor for detecting Staphylococcal quorum sensing. ACS Synthetic Biology., 2018 DOI: 10.1021/acssynbio.8b00063 (* all authors contributed equally)
3. Hoang LP*, Ho CL*, Wong Adison*, Lee YS, Chang MW. Applying the design-build-test paradigm in microbiome engineering. Current Opinion in Biotechnology, 2017, 48, 85-93 (* all authors contributed equally)
4. Ho CL, Hwang IY, Loh K, Chang MW. Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin. MedChemComm, 2015, 6, 486-491
5. Ho CL, Chong KSJ, Akosua JO, Chuah MLC, Tan SM, Liang ZX. Visualizing the Perturbation of Cellular Cyclic di-GMP Levels in Bacterial Cells. Journal of the American Chemical Society, 2013, 135 (2), pp 566–569
6. Ho CL, Koh SL, Chuah MLC, Luo Z, Tan WJ, Low DKS, Liang ZX. Rational Design of Fluorescent Biosensor for cyclic di-GMP. Chembiochem: a European journal of chemical biology., 2011, 12(18):2753-8
7. Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, Chang MW. Reprogramming Microbes to Be Pathogen-Seeking Killers. ACS Synthetic Biology., 2013, DOI: 10.1021/sb400077j
8. Rasouliha BH, Ling H, Ho CL, Chang MW. A predicted immunity protein confers resistance to pyocin S5 in a sensitive strain of Pseudomonas aeruginosa. Chembiochem: a European journal of chemical biology., 2013, DOI: 10.1002/cbic.201300410
9. Sun H, Ho CL, Ding F, Soehano I, Liu XW, Liang ZX. Synthesis of (R)-Mellein by a Partially Reducing Iterative Polyketide Synthase. Journal of the American Chemical Society. 2012; 134(29):11924-7.
10. Qi Y, Xu LH, Dong XM, Yau YH, Ho CL, Koh SL, Shochat SG, Chou SH, Tang K, Liang ZX. Functional Divergence of FimX in PilZ binding and Type IV Pili Regulation. Journal of bacteriology. 2012
11. Lim J, Kong R, Murugan E, Ho CL, Liang ZX. Solution Structures of the Acyl Carrier Protein Domain from the Highly Reducing Type I Iterative Polyketide Synthase CalE8. PloS one. 6(6):e20549.