个人简历

工作经历
2014—至今，南方科技大学生物系，副教授
2007-2014， 中国科学院广州生物医药与健康研究院，研究员
1999-2007， 德国哥廷根大学医学院博士后
1989-1995， 西北师范大学生物系，助教、讲师
教育背景
1999年，获德国Essen大学动物生理系博士学位
1989年，获西北师范大学生物系硕士学位
1986年，获西北师范大学生物系学士学位

研究领域

1. 胰腺发育与再生的分子机理
2. 癌症动物模型

近期论文

1. Shi, Z., Xin, H., Tian, D., Lian, J., Wang, J., Liu, G., Ran, R., Shi, S., Zhang, Z., Shi, Y., Deng, Y., Hou, C., and Chen, Y. 2019. Modeling human point mutation diseases in Xenopus tropicalis with a modified CRISPR/Cas9 system. FASEB J. 33, 6962-6968.
2. Shi, Z., Tian, D., Xin, H., Lian, J., Guo, X., and Chen, Y. 2017. Targeted integration of genes in Xenopus tropicalis. Genesis 55(1-2).
3. Shi, Z., Wang, F., Cui, Y., Liu, Z., Guo, X., Zhang, Y., Deng, Y., Zhao, H., and Chen, Y. 2015. Heritable CRISPR/Cas9-mediated targeted integration in Xenopus tropicalis. FASEB J.29, 4914-4923.
4. Guo, X., Zhang, T., Hu, Z., Zhang, Y., Shi, Z., Wang, Q., Cui, Y., Wang, F., Zhao, H., and Chen, Y. 2014. Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development 141, 707-714.
5. Zhao, H., Han, D., Dawid, I.B., Pieler, T., and Chen, Y. 2012. Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos. Proc. Natl. Acad. Sci. U S A. 109，8594-8599.
6. Lei, Y., Guo, X., Liu, Y., Cao, Y., Deng, Y., Chen, X., Cheng, C.H., Dawid, I.B., Chen, Y., and Zhao, H. 2012. Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc. Natl. Acad. Sci. U S A. 109, 17484-17489.
7. Wen, L., Yang, Y., Wang, Y., Xu, A., Wu, D., and Chen, Y. 2010. Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells. Dev. Dyn. 239, 2198-2207.
8. Afelik, S., Chen, Y. and Pieler, T. 2006. Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue. Genes Dev. 20, 1441-1446.
9. Chen, Y., Pan, F. C., Brandes, N., Afelik, S., Sölter, M. and Pieler, T. 2004. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev. Biol. 271, 144-160.
10. Hollemann, T., Chen, Y., Grunz, H. and Pieler, T. 1998. Regionalized metabolic activity establishes boundaries of retinoic acid signalling. EMBO J. 17, 7361-7372.