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张大雷
2023-05-11 13:23
  • 张大雷
  • 张大雷 - 教授-南昌大学江西医学院-基础医学院-个人资料

近期热点

资料介绍

个人简历


教育和工作背景:
2007毕业于浙江大学获博士学位
2007-2011南昌大学基础医学院讲师
2011-2016南昌大学基础医学院副教授
2016-至今南昌大学基础医学院教授、博士生导师
研究兴趣、领域:
主要研究方向为生殖生理与病理;体外配子发生;肝脏、生殖与发育毒理及其调控。近年来主持国家自然科学基金、江西省自然科学基金及江西省教育厅科技项目等多项科研项目,在国际学术期刊上发表SCI收录论文20余篇。
近年来所获科研项目:
1.国家自然科学基金“PFOA诱导睾丸生殖细胞毒性损伤的机制及Nrf2的调控
作用研究”,2016.1-2019.12,81560248,主持。
2.国家自然科学基金“Nrf2-ARE系统调控环境内分泌干扰物引起的精原细胞
毒性损伤的研究”2011.1-2013.12,81060056,主持。
3.江西省自然科学基金“Nrf2调控PFOA诱导的睾丸生殖毒性损伤的研究”,
2016.1-2018.12,20161BAB205208,主持。
4.江西省教育厅科技项目“内分泌干扰物诱导精原细胞氧化损伤及其修复机
制的研究”,2012.1-2014.12,GJJ12083,主持。
5.江西省教育厅科技项目“人参皂甙对雄性生殖细胞发育调控的研究”,
20109.1-2011.12,主持。
6.国家自然科学基金“雌性骨髓间充质干细胞悬滴培养形成卵泡样结构和产
生性激素的研究”,2010.1-2013.12,30960409,排名第三。
7.国家自然科学基金“甲状旁腺全切除后骨髓细胞甲状旁腺素的合成和调节
研究”,2016.1-2019.12,2015年立项,81502417,在研,排名第二。

研究领域


生殖生理与病理;体外配子发生;肝脏、生殖与发育毒理及其调控。

近期论文


1.DaleiZhang,YalingWu,YangyangYuan,WenwenLiu,Haibin,Kuang,JianhuaYang,BeiYang,LeiWu,WeiyingZou,ChangshuiXu.Exposureto2,4-dichlorophenoxyaceticacidinducesoxidativestressandapoptosisinmousetestis.PesticideBiochemistryandPhysiology,2017,141:18-22
2.YuanY,GeS,LvZ,WuM,KuangH,YangB,WuLei,ZhangD*.Attenuationofperfluorooctanoicacid-inducedtesticularoxidativestressandapoptosisbyquercetininmice.RSCAdvances,2017,7(71),45045-45052
3.MoLi,YifanJia,YanLing,YiluChen,LuZhang,DanLuo,LidanLai,MeijunGuo,DaleiZhang,MinRen,HongXu,HaibinKuang.ReducedexpressionoffolliclestimulatinghormonereceptormRNAandproteininpregnanciescomplicatedbypre-eclampsia.Molecularmedicinereports,2017,16(1),367-372.
4.WenwenLiu,ChangshuiXu,XiSun,HaibinKuang,XiaodongKuang,WeiyingZou,BeiYang,LeiWu,FangmingLiu,TingZou,DaleiZhang*.Grapeseedproanthocyanidinextractprotectsagainstperfluorooctanoicacid-inducedhepatotoxicitybyattenuatinginflammatoryresponse,oxidativestressandapoptosisinmice.ToxicologyResearch,2016,5:224-234.
5.ZouWeiying,LinHua,LiuWenwen,YangBei,WuLei,DuanLimin,LingPing,ZhuLingyan,DaiQun,ZhaoLintong,ZouTing,DaleiZhang*.Moxibustion
relievesvisceralhyperalgesiaviainhibitionoftransientreceptorpotentialvanilloid1(TRPV1)andheatshockprotein(HSP)70expressioninratbonemarrowcells.AcupunctMed,2016,34(2):114-119.
6.ChenYilu,ZhouLing,XuJingjie,Zhang,Lu,LiMo,XieXingxing,XieYajuan,LuoDan,ZhangDalei,YuXiaochun,YangBei,KuangHaibin.Maternalexposuretoperfluorooctanoicacidinhibitslutealfunctionviaoxidativestressandapoptosisinpregnantmice.ReprodToxicol,2017,69:159-166.
7.QinShanshan,ChenQiang,WuHui,LiuChenglong,HuJing,ZhangDalei,XuChangshui.Effectsofnaringinonlearningandmemorydysfunctioninducedbygp120inrats.BrainResBull,2016,124:164-171.
8.WenwenLiu,BeiYang,LeiWu,WeiyingZou,XiaolingPan,TingZou,LipingXia,DaleiZhang*.InvolvementofNRF2inPerfluorooctanoicAcid-InducedTesticularDamageinMaleMice.BiologyofReproduction.2015,93,41:1-7.
9.WeiyingZou,WenwenLiu,BeiYang,LeiWu,JianhuaYang,TingZou,LipingXia,DaleiZhang*.Quercetinprotectsagainstperfluorooctanoicacid-inducedliverinjurybyattenuatingoxidativestressandinflammatoryresponseinmice.InternationalImmunopharmacology.2015,28:129-135.10.XuJingjie,LiMo,ZhangLu,XiongHao,LaiLidan,GuoMeijun,ZongTeng,ZhangDalei,YangBei,WuLei,TangMin,KuangHaibin*.Expressionandregulationofandrogenreceptorinthemouseuterusduringearlypregnancyanddecidualization.MolReprodDev,2015,82(11):898-906.
11.ZongTeng,LaiLidan,HuJia,GuoMeijun,LiMo,ZhangLu,ZhongChengxue,YangBei,WuLei,ZhangDalei,TangMin,KuangHaibin*.Maternalexposuretodi-(2-ethylhexyl)phthalatedisruptsplacentalgrowthanddevelopmentinpregnantmice.JHazardMater,2015,297:25-33.
12.Fen-FangHong,Fa-XianGuo,YingZhou,Qin-HuaMin,Da-LeiZhang,BeiYang,Wei-YingZhou,LeiWu,Zhi-PingWei,HuiLiu,Shu-LongYang*.ShenfuinjectionprotectshumanECV304cellsfromhydrogenperoxideviaitsanti-apoptosisway.JournalofEthnopharmacology,2015,163(2):203-209.
13.BeiYang,WeiyingZou,ZhenzhenHu,FangmingLiu,LingZhou,ShulongYang,HaibinKuang,TingZou,DaleiZhang*,InvolvementofOxidativeStressandInflammationinLiverInjuryCausedbyPerfluorooctanoicAcidExposureinMice,BioMedResearchInternational,2014,409837:1-7
14.ZhenyuCai,DaleiZhang,YingYing,MinYan,JianhuaYang,FangyunXu,KiwanOh,ZhenzhenHu*.InhibitorymodulationofCARTpeptidesinaccumbalneuronthroughdecreasinginteractionofCaMKIIαwithdopamineD3receptors.BrainResearch,2014,1557:101-110.(co-firstauthor)
15.DaleiZhang,BeiYang,WeiyingZou,,MingdiXiong,LeiWu,JingleiWang,,SifanXu,TingZou*,Estradiolsynthesisandreleaseinculturedfemaleratbonemarrowstemcells.BioMedResearchInternational,2013,301540:1-6
16.LipingZheng,JiangHuang,DaleiZhang,LiangquangXu,FangLi,LeiWu,ZhengyuLiu,YuehuiZheng*.c-erbB(2)andc-mybInduceMouseOocyteMaturationInvolvingActivationofMaturationPromotingFactor.DNAandCellBiology,2012,31(2):164-170.(co-firstauthor)
17.ZhengLP,ZhangDL,HuangJ,XuLQ,XuAX,DuXY,TangDF,ZhengYH.Proto-oncogenec-erbB2initiatesratprimordialfolliclegrowthviaPKCandMAPKpathways.ReproductiveBiologyandEndocrinology.2010,8(66):1-16.(co-firstauthor)
18.ZhangDalei,WangKaiming,ZhangCaiqiao.GinsenosidesstimulatedtheproliferationofmousespermatogoniainvolvingactivationofproteinkinaseC.JZhejiangUnivSciB.2009,10(2):87-92.
19.ZhangDa-lei,MiYu-Ling,WangKai-ming,ZengWei-dong,ZhangCai-qiao.Attenuatingeffectofdaidzeinonpolychlorinatedbiphenyls-inducedoxidativetoxicityinmousetesticularcells.JZhejiangUnivSciB.2008,9(7):567-571.
20.DaleiZhang,CaiqiaoZhang,JianxinLiu.Ginsenosidespromotemeioticmaturationofmouseoocytesincumulus-oocytecomplexesinvolvingincreasedexpressionofnitricoxidesynthase.NutritionResearch.2006,26(11):585-590.

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