个人简历

华中科技大学同济医学院博士毕业。曾获国际脑研究组织（IBRO）资助，赴匈牙利科学院实验医学研究所神经药理系研究学习二年。另申请到英国威康研究基金（WellcomeTrust）的科研课题资助，在英国伦敦大学学院自主神经科学研究所开展过研究工作。2009年赴美国内布拉斯加大学医学院药理和实验神经科学系进行工作访问，并被聘为内布拉斯加大学医学院药理和实验神经科学系客座教授（VisitingProfessor）。
研究兴趣、领域：
课题组致力于多年来一直从事外周神经节的生理、病理生理与药理学研究工作。主要从事神经病理痛外周神经损伤、心肌缺血与外周神经节病理生理、糖尿病并发外周神经损伤、糖尿病血管内皮损伤等研究。
主持完成国家自然科学基金课题六项
《川芎嗪对P2X3受体介导的伤害性感受的作用及机理研究；主持，批准号：30260030》、《P2X3受体在颈部交感神经节细胞介导心肌痛伤害性信息传递的作用研究；主持，批准号：30460040》、《P2X2/3受体在结状神经节细胞介导心肌痛伤害性信息传递的作用研究；主持，批准号：30660048》、《初级感觉神经元血管内皮生长因子及其受体在神经病理痛中的作用及机理研究；主持，批准号：30860086》、《颈部交感神经节P2X7受体与心肌缺血损伤介导失稳态交感反射的研究；主持，批准号：31060139》和《自主和初级感觉神经节中与糖尿病神经病变相关的类似mRNA的非编码RNA作用研究；主持，项目批准号：81171184》；主持完成一项教育部高等学校博士点专项科研基金课题《葛根素对初级感觉神经元P2X3受体介导烧伤痛的作用研究（批准号：20070403007）》。
现主持二项国家自然科学基金课题《背根神经节嘌呤2X受体介导HIV及其治疗相关神经病理痛的作用机制和拮抗研究；主持，项目批准号：31560276》和《背根神经节神经元与卫星胶质细胞间作用涉及探究糖尿病神经病理痛机制和潜在治疗靶点的新途径；主持，项目批准号：81570735》。发表研究论文130多篇（其中SCI收录杂志69篇）。获江西省自然科学二等奖一项、江西省自然科学三等奖二项（均为第一完成人）。获批美国发明专利一项、中国知识产权局发明专利二项（均为第一完成人）。

研究领域

主要从事神经病理痛外周神经损伤、心肌缺血与外周神经节病理生理、糖尿病并发外周神经损伤、糖尿病血管内皮损伤等研究。

近期论文

XuH,XiongC,HeL,WuB,PengL,ChengY,JiangF,TanL,TangL,TuY,YangY,LiuC,GaoY,LiG,ZhangC,LiuS,XuC,WuH,LiG,LiangS(梁尚栋)*.Trans-ResveratrolAttenuatesHighFattyAcid-InducedP2X7ReceptorExpressionandIL-6ReleaseinPC12Cells:PossibleRoleofP38MAPKPathway.Inflammation.2015,38(1):327-37.LiuSM,ShiQM,ZhuQC,ZouT,LiGL,HuangA,WuB,PengLC,SongMM,WuQ,XieQY,LinWJ,XieW,WenSY,ZhangZD,LvQL,ZouLF,ZhangX,YingMF,LiGD,LiangSD(梁尚栋)*.P2X7receptorofratdorsalrootgangliaisinvolvedintheeffectofmoxibustiononvisceralhyperalgesia.PurinergicSignalling,2015,11(2):161-169.GaoY,ZhangJ,LiGL,XuH,YiY,WuQ,SongMM,BeeYM,HuangLP,TanMG,LiangSD(梁尚栋),LiGD.Protectionofvascularendothelialcellsfromhighglucose-inducedcytotoxicitybyemodin.BiochemicalPharmacology,2015,94(1):39-45.ZhangJ,LiuSM,XuBH,LiGD,LiGL,WuB,PengLC,SongMM,WuQ,XieQY,LinWJ,XieW,WenSY,ZhangZD,XuXL,LvQL,ZouLF,ZhangX,YingMF,LiangSD(梁尚栋)*.StudyofbaicalinonsympathoexcitatoryactivityinducedbymyocardialischemiaviaP2X3receptorinratsuperiorcervicalganglia.AutonomicNeuroscience:BasicandClinical,2015,189:815.XiongW,QiuSY,XuLY,ZhangCP,YiY,WuQ,HuangLP,LiuSM,WuB,PengLC,SongMM,GaoY,LiangSD(梁尚栋)*.EffectofintermedinindorsalrootgangliaonthetransmissionofneuropathicpainofCCIrats.ClinicalandExperimentalPharmacologyandPhysiology,2015,42(7):780–787.WuH,NieYY,XiongHG,LiuSM,LiGL,HuangA,GuoLL,WuB,
PengLC,SongMM,LiGD,LiangSD(梁尚栋)*.P2X7receptorexpressioninperipheralbloodmonocytesiscorrelatedwithplasmaCreactiveproteinandcytokinelevelsinpatientswithtype2diabetesmellitus:apreliminaryreport.Inflammation,2015,38(6):2076-2081.LvQL,XueY,LiGD,ZouLF,ZhangX,YingMF,WangSY,GuoLL,GaoY,LiGL,XuH,LiuSM,XieJY,LiangSD(梁尚栋)*.BeneficialeffectsofevodiamineonP2X4-mediatedinflammatoryinjuryofhumanumbilicalveinendothelialcellsduetohighglucose.InternationalImmunopharmacology,2015,28:1044–1049.LvQL,WangK,XuDZ,LiuMY,WanQ,HuangHY,LiangSD(梁尚栋),ZhangXY(张小勇),WeiY.SynthesisofamphiphilichyperbranchedAIE-activefluorescentorganicnanoparticlesandtheirapplicationinbiologicalapplication.MacromolecularBioscience,2016,16(2):223-230.DOI:10.1002/mabi.201500256ZouLF,TuGH,XieW,WenSY,XieQY,LiuSM,LiGL,GaoY,XuH,WangSY,XueY,WuB,LvQL,YingMF,ZhangX,LiangSD(梁尚栋)*.ThelongnoncodingRNANONRATT021972isinvolvedinthepathophysiologicprocessesmediatedbyP2X7receptorsinstellategangliaaftermyocardialischemicinjury.PurinergicSignalling,2016,12(1):127-137.WangSY,XuH,ZouLF,XieJY,WuH,WuB,YiZH,LvQL,ZhangX,YingMF,LiuSM,LiGL,GaoY,XuCS,ZhangCP,XueY,LiangSD(梁尚栋)*.LncRNAuc.48+isinvolvedindiabeticneuropathicpainmediatedbytheP2X3receptorinthedorsalrootganglia.PurinergicSignalling,2016,12:139-148.WuB,ZhangCP,ZouLF,MaYC,HuangKY,LvQL,ZhangX,WangSY,XueY,YiZH,JiaTY,ZhaoSH,LiuSM,XuH,LiGL,LiangSD(梁尚栋)*.LncRNAuc.48+siRNAimproveddiabeticsympatheticneuropathyintype2diabeticratsmediatedbyP2X7receptorinSCG.AutonomicNeuroscience:BasicandClinical,2016,197:14–18.LiGL,ZouLF,XieW,WenSY,XieQY,GaoY,XuCS,XuH,Liu,SM,WangSY,XueY,WuB,LvQL,YingMF,ZhangX,LiangSD(梁尚栋)*.TheeffectsofNONRATT021972lncRNAsiRNAonPC12neuronalinjurymediatedbyP2X7receptorafterexposuretooxygen-glucosedeprivation.Purin
ergicSignalling,2016,12(3):479-87.DOI:10.1007/s11302-016-9513-8(出版年:2016-Sep(EpubApr21))LiuSM,ZouLF,XieJJ,XieW,WenSY,XieQY,GaoY,LiGL,ZhangCP,XuCS,XuH,WuB,LvQL,ZhangX,WangSY,XueY,LiangSD(梁尚栋)*.LncRNANONRATT021972siRNAregulatesneuropathicpainbehaviorsintype2diabeticratsthroughtheP2X7receptorindorsalrootganglia.MolBrain.2016;9:44.Publishedonline2016April23.doi:10.1186/s13041016-0226-2TuGH,ZouLF,LiuSM,WuB,LvQL,WangSY,XueY,ZhangCP,YiZH,ZhangX,LiGL,LiangSD(梁尚栋)*.LongnoncodingNONRATT021972siRNAnormalizedabnormalsympatheticactivitymediatedbytheupregulationofP2X7receptorinsuperiorcervicalgangliaaftermyocardialischemia.PurinergicSignalling,2016,12:521–535.LvQL,WangK,XuDZ,LiuMY,WanQ,HuangHY,LiangSD(梁尚栋),ZhangXY,WeiY.Facilepreparationandbiologicalimagingofluminescentpolymericnanoprobeswithaggregation-inducedemissioncharacteristicsthroughMichaeladditionreaction.ColloidsandSurfacesB:Biointerfaces,2016,145:795–801.XuH,HeLL,LiuCL,TangL,XuYH,XiongMQ,YangM,FanYF,HuFF,LiuXZ,DingL,GaoY,XuCS,LiGL,LiuSM,WuB,ZouLF,LiangSD(梁尚栋)*.LncRNANONRATT021972siRNAattenuatesP2X7receptorexpressionandinflammatorycytokineproductioninducedbycombinedhighglucoseandfreefattyacidsinPC12cells.PurinergicSignalling,2016,12(2):259–268.Publishedonline2016Feb10.doi:10.1007/s11302-016-9500-0WuH,LiGD,NieYJ,ZouLF,ZhangX,LiuSM,LiGL,XuH,ZhangCP,LiangSD(梁尚栋)*.PotentialinvolvementofP2receptorsinthepathologicalprocessesofhyperthyroidism:apilotstudy.AnnalsofClinicalandLaboratoryScience,2016,46(3):254-259.ChenQ,HuJ,QinSS,LiuCL,WuH,WangJR,LuXM,WangJ,ChenGQ,LiuY,LiuBY,XuCS,Liang,S(梁尚栋).Protectiveeffectsofnaringinagainstgp120-inducedinjurymediatedbyP2X7receptorsinBV2microglialcells.GeneticsandMolecularResearch,2016,15(2):DOI:10.4238/gmr.15028649
XuH,LiuCL,RaoSQ,HeLL,ZhangTL,SunSS,WuB,ZouLF,WangSY,XueY,JiaTY,ZhaoSH,LiGL,LiuSM,LiGD,LiangSD(梁尚栋)*.LncRNANONRATT021972siRNArescueddecreasedheartratevariabilityindiabeticratsinsuperiorcervicalganglia.AutonomicNeuroscience:BasicandClinical,2016,201:1–7.WangJ,LiuSM,NieYJ,WuB,WuQ,SongMM,TangM,XiaoL,XuP,TanXM,ZhangLY,LiG,LiangSD,ZhangCP.ActivationofP2X7receptorsdecreasestheproliferationofmurinelutealcells.Reproduction,Fertility,andDevelopment,2015,27(8):1262-1271.DOI:10.1071/RD14381LiuH,LiuJN,XuEQ,TuGH,GuoML,LiangSD(梁尚栋),XiongHG.HumanimmunodeficiencyvirusproteinTatinducesoligodendrocyteinjurybyenhancingoutwardK+currentconductedbyKV1.3.NeurobiologyofDisease,2017,97(PartA):1-10.PengHY,ZouLF,XieJY,WuH,WuB,ZhuGC,LvQL,ZhangX,LiuSM,LiGL,XuH,GaoY,XuCS,ZhangCP,WangSY,XueY,LiangSD(梁尚栋)*.LncRNANONRATT021972siRNAdecreasesdiabeticneuropathicpainmediatedbytheP2X3receptorindorsalrootganglia.MolecularNeurobiology,2017,54:511–523.LiGL,ShengX,XuYR,JiangHD,ZhengCR,GuoJJ,SunSS,YiZH,QinSL,LiuSM,GaoY,ZhangCP,XuH,WuB,ZouLF,LiangSD(梁尚栋)*,ZhuGC.Co-expressionchangesoflncRNAsandmRNAsinthecervicalsympatheticgangliaindiabeticcardiacautonomicneuropathicrats.JournalofNeuroscienceResearch,2017,95:1690–1699.RaoSQ,LiuSM,ZouLF,JiaTY,ZhaoSH,WuB,YiZH,WangSY,XueY,GaoY,XuCS,LiGL,XuH,ZhangCP,LiangSD(梁尚栋)*.TheeffectofsinomenineindiabeticneuropathicpainmediatedbytheP2X3receptorindorsalrootganglia.PurinergicSignalling,2017,13(2):227–235.(Erratum:PurinergicSignalling(2017)13:237).XieJY,LiuSM,WuB,LiGL,RaoSQ,ZouLF,YiZH,ZhangCP,JiaTY,ZhaoSH,SchmalzingG,HausmannR,NieH,LiGD,LiangSD(梁尚栋)*.TheprotectiveeffectofresveratrolinthetransmissionofneuropathicpainmediatedbytheP2X7receptorinthedorsalrootganglia.NeurochemistryInternational,2017,103:24-35.
YiZH,RaoSQ,OuyangSA,BaiY,WuB,ZouLF,WangSY,XueY,JiaTY,ZhaoSH,GaoY,LiuSM,XuH,ZhangCP,LiangSD(梁尚栋)*,GuilinLi.A317491relievedHIVgp120-associatedneuropathicpaininvolvedinP2X3receptorindorsalrootganglia.BrainResearchBulletin,2017,130:81–89.YingM,LiuH,ZhangT,JiangC,GongY,WuB,ZouL,YiZ,RaoS,LiG,ZhangC,JiaT,ZhaoS,YuaH,ShiL,LiL,LiangS(梁尚栋)*,LiuS.EffectofartemisininonneuropathicpainmediatedbyP2X4receptorindorsalrootganglia.NeurochemistryInternational,2017,108:27-33.SongMM,ZouLF,PengLC,LiuSM,WuB,YiZH,GaoY,ZhangCP,XuH,XuYR,TangMX,WangSY,XueY,JiaTY,ZhaoSH,LiangSD(梁尚栋)*,LiGL.LncRNANONRATT021972siRNAnormalizedthedysfunctionofhepaticglucokinasethroughAKTsignalinginT2DMrats.EndocrineResearch,2017,42(3):180-190.WuB,MaYC,YiZH,LiuSM,RaoSQ,ZouLF,WangSY,XueY,JiaTY,ZhaoSH,ShiLR,LinLi,YuanHL,LiangSD(梁尚栋)*.Resveratrol-decreasedhyperalgesiamediatedbytheP2X7receptoringp120-treatedrats.MolecularPain,2017,13:1–9.XuH,GongCX,HeLL,RaoSQ,LiuXZ,NieYJ,LiuCL,LiT,DingL,TuYM,YangYP,HuFF,FanYF,WangH,WangS,XiongCP,ZhongPP,TangL,LiangSD(梁尚栋)*.PurinergicP2X7receptorfunctionalgeneticpolymorphismsareassociatedwiththesusceptibilitytoosteoporosisinChinesepostmenopausalwomen.PurinergicSignalling,2017,May11.doi:10.1007/s11302-017-9566-3.[Epubaheadofprint].XiongW,TanM,HeL,OuX,JinY,YangG,HuangL,ShenY,GuanS,XuC,LiG,LiuS,XuH,LiangS(梁尚栋)*,GaoY.InhibitoryeffectsoftetramethylpyrazineonpaintransmissionoftrigeminalneuralgiainCCI-IONrats.BrainResBull.,2017,134:72-78.LiG,JiangH,ZhengC,ZhuG,XuY,ShengX,WuB,GuoJ,ZhuS,ZhanY,LinW,DingR,ZhangC,LiuS,ZouL,YiZ,LiangS(梁尚栋)*.LongnoncodingRNAMRAK009713isanovelregulatorofneuropathicpaininrats.Pain.2017Oct;158(10):2042-2052.LiL,ShengX,ZhaoSH,ZouLF,HanXY,GongYX,YuanHL,ShiL
R,GuoLL,JiaTY,LiuSM,WuB,YiZH,LiuH,GaoY,LiGL,LiGD,ZhangCP,XuH,LiangSD(梁尚栋)*.Nanoparticle-encapsulatedemodindecreasesdiabeticneuropathicpainprobablyviaamechanisminvolvingP2X3receptorinthedorsalrootganglia.PurinergicSignalling,2017,13:559–568.ShiLR,WuB,YiZH,ZhaoSH,ZouLF,LiL,YuanHL,JiaTY,LiuSM,LiuH,GaoY,LiGL,XuH,ZhangCP,LiangSD(梁尚栋)*.P2Y12shRNAtreatmentrelievedHIVgp120-inducedneuropathicpaininrats.NeurochemistryInternational,2018,112:259-266.ZhaoS,YangJ,HanX,GongY,RaoS,WuB,YiZ,ZouL,JiaT,LiL,YuanH,ShiL,ZhangC,GaoY,LiG,LiuS,XuH,LiuH,LiangS(梁尚栋)*.Effectsofnanoparticle-encapsulatedcurcuminonHIV-gp120-associatedneuropathicpaininducedbytheP2X3receptorindorsalrootganglia.BrainResBull.2017Oct;135:53-61.WuB,PengL,XieJ,ZouL,ZhuQ,JiangH,YiZ,WangS,XueY,GaoY,LiG,LiuS,ZhangC,LiG,LiangS(梁尚栋)*,XiongH.TheP2X7receptorindorsalrootgangliainvolvedinHIVgp120-associatedneuropathicpain.BrainResBull.2017Oct;135:25-32.ZouLF,GongYX,ZhaoSH,YiZH,HanXY,WuB,JiaTY,LiL,YuaHL,ShiLR,ZhangCP,GaoY,LiGL,XuH,LiuH,LiangSD(梁尚栋)*,LiuSM.DownregulationofP2Y12inthesuperiorcervicalgangliaalleviatesabnormalsympatheticactivityaftermyocardialischemia.JournalofCellularPhysiology,2018,233(4):3375–3383.2017.DOI:10.1002/jcp.26184GuoLL,LiL,LiuMY,WanQ,TianJW,HuangQ,WenYQ,LiangSD(梁尚栋)*,ZhangXY*,WeiY*:Bottom-uppreparationofnitrogendopedcarbonquantumdotswithgreenemissionundermicrowave-assistedhydrothermaltreatmentandtheirbiologicalimaging.MaterialsScienceandEngineering:C2017;60-66.JiaT,RaoJ,ZouL,ZhaoS,YiZ,WuB,LiL,YuanH,ShiL,ZhangC,GaoY,LiuS,XuH,LiuH,LiangS(梁尚栋)*,LiG.Nanoparticle-EncapsulatedCurcuminInhibitsDiabeticNeuropathicPainInvolvingtheP2Y12ReceptorintheDorsalRootGanglia.Frontiersinneuroscience.2017;11:755.YiZH,XieLH,ZhouCF,YuanHL,OuyangSA,FangZ,ZhaoSH,JiaTY,ZouLF,WangSY,XueY,WuB,GaoY,LiGL,LiuSM,XuH,Xu
CS,ZhangCP,LiangSD(梁尚栋)*.P2Y12receptorupregulationinsatelliteglialcellsisinvolvedinneuropathicpaininducedbyHIVglycoprotein120and2′,3′-dideoxycytidine.PurinergicSignalling,2018,14(1),47-58.YiZ,OuyangS,ZhouC,XieL,FangZ,YuanH,YangJ,ZouL,JiaT,ZhaoS,LiL,ShiL,GaoY,LiG,LiuS,XuH,XuC,ZhangCandLiangS(梁尚栋)*.AndrographolideInhibitsMechanicalandThermalHyperalgesiainaRatModelofHIV-InducedNeuropathicPain.Front.Pharmacol.2018,9:593.doi:10.3389/fphar.2018.00593ZouL,HanX,LiuS,GongY,WuB,YiZ,LiuH,ZhaoS,JiaT,LiL,YuaH,ShiL,ZhangC,GaoY,LiG,XuH,LiangS(梁尚栋)*.BaicalinDepressestheSympathoexcitatoryReflexInducedbyMyocardialIschemiaviatheDorsalRootGanglia.Front.Physiol.2018,9:928.doi:10.3389/fphys.2018.00928YangR,LiL,YuanH,LiuH,GongY,ZouL,LiS,WangZ,ShiL,JiaT,ZhaoS,WuB,YiZ,GaoY,LiG,XuH,LiuS,ZhangC,LiG,LiangS(梁尚栋)*.QuercetinrelieveddiabeticneuropathicpainbyinhibitingupregulatedP2X4receptorindorsalrootganglia.JournalofCellularPhysiology,2018,accepted.XueY,GuoT,ZouL,GongY,WuB,YiZ,JiaT,ZhaoS,ShiL,LiL,YuanH,LiuH,GaoY,LiG,LiuS,XuH,ZhangC,LiangS(梁尚栋)*,LiG.EvodiamineattenuatesP2X7-mediatedinflammatoryinjuryofhumanumbilicalveinendothelialcellsexposedtohighfreefattyacids.OxidativeMedicineandCellularLongevity,2018,accepted.
国际脑研究组织会员、中国神经科学会理事、江西省生理科学会理事长、江西省神经科学学会副理事长。AutonomicNeuroscience:BasicandClinical(SCI收录)杂志编委。Pain、MolecularNeurobiology、BritishJournalofPharmacology、Neuropharmacology、JournalofCellularPhysiology、ACSChemicalNeuroscience、JournalofBiomedicine&Pharmacotherapy、CurrentMedicinalChemistry、PLoseone、PurinergicSignaling、AdvancesinPharmacology等国际杂志审稿专家。