胡贞贞
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教育和工作背景:2004赣南医学院临床医学专业学士2007中山大学医学院病理生理学硕士2012韩国忠北国立大学药学专业博士2017-2018中国科学院上海神经科学研究所访问学者2017-至今南昌大学基础医学院副教授、硕士生导师研究兴趣、领域:课题组致力于中脑边缘脑内多巴胺能和GABA能神经通路研究。从而为临床治疗相关神经精神疾病,如药物成瘾,老年痴呆,帕金森等疾病提供新的思路。近年来研究成果发表在本领域的国际期刊:BehaviouralPharmacology,Neurochemistryinternational,BrainResearch,PLoSOne,FrontCellNeurosci.,JournalofNeurochemistry等。所获项目、荣誉、奖励及参加学术团体的情况:1.神经科学国家重点实验室开放课题,SKLN-201701,基于GABA能神经元GABABR转运上膜的可卡因成瘾分子机制,2018.1-2018.12,5万元,在研,主持2.江西省自然科学青年基金重点项目,20171ACB21002,伏隔核CART活性肽治疗毒品成瘾的作用及机制研究,2017.1-2019.12,20万元,在研,主持3.江西省自然科学基金一般项目,20161BBG70065,CART基因应用于抑郁症诊断和治疗及机制研究,2016.1-2018.12,5万元,在研,主持4.江西省卫生厅青年项目,2015A041,酸枣仁汤对原发性失眠和抑郁症失眠的治疗及机制研究,0.4万元,在研,主持5.国家自然科学基金青年基金项目,81201035,伏隔核CART通过钙离子调节CaMK-D3R负反馈调节可卡因奖赏效应,2013/01-2015/12,23万元,已结题,主持近期论文
1XiongL,MengQ,SunX,LuX,FuQ,PengQ,YangJ,OhKW,HuZ#.CARTpeptideinthenucleusaccumbensshellinhibitscocaine-inducedlocomotorsensitizationtotransientoverexpressionofα-Ca2+/Calmodulin-dependentProteinKinaseII.JNeurochem.2018Jan4.doi:10.1111/jnc.14289.(#Correspondingauthor)2HuQ,HuZ,ChenQ,HuangY,MaoZ,XuF,ZhouX.BML-111equilibratedACE-AngII-AT1RandACE2-Ang-(1-7)-Masaxistoprotecthepaticfibrosisinrats.ProstaglandinsOtherLipidMediat.2017Jul;131:75-82.doi:10.1016/j.prostaglandins.2017.08.008.3YuC,ZhouX,FuQ,PengQ,OhKW,HuZ#.ANewInsightintotheRoleofCARTinCocaineReward:InvolvementofCaMKIIandInhibitoryG-ProteinCoupledReceptorSignaling.FrontCellNeurosci.2017Aug15;11:244.doi:10.3389/fncel.(#CorrespondingAuthor)4FuQ,ZhouXY,DongY,HuangYH,YangJH,OhKW,andHuZ#.DecreasedCaffeine-InducedLocomotorActivityviaMicroinjectionofCARTPeptideintotheNucleusAccumbensIsLinkedtoInhibitionofthepCaMKIIa-D3RInteraction.2016,PLoSOne11:e0159104(#CorrespondingAuthor)5HuZZ,OhEH,ChungYB,HongJT,andOhKW.PredominantD1ReceptorsInvolvementintheOver-expressionofCARTPeptidesafterRepeatedCocaineAdministration。2015,KoreanJPhysiolPharmacol19:89-976PengQH,SunX,LiuZY,YangJH,OhKW,andHuZ#.MicroinjectionofCART(cocaine-andamphetamine-regulatedtranscript)peptideintothenucleusaccumbensinhibitsthecocaine-inducedupregulationofdopaminereceptorsandlocomotorsensitization.2014.Neurochemistryinternational75:105-111.(#CorrespondingAuthor)7CaiZY,ZhangDL,YingY,YanM,YangJH,XuFY,OhKW,andHuZ#.InhibitoryModulationofCARTPeptidesinAccumbalneuronthroughDecreasingInteractionofCaMKIIαwithDopamineD3receptors.2014.BrainResearch1557:101-110.(#CorrespondingAuthor)8HuZZ,LeeCII,HanJY,OhEH,RyuJH,HongJT,KimYSandOhKW.Caffeineinducesbehaviouralsensitizationandoverexpressionofcocaine-regulatedandamphetamine-regulatedtranscriptpeptidesinmice(2014).BehaviouralPharmacology25:32-43.9HuZZ,LeeChung-II,ShahVikashKumar,OhEun-Hye,HanJin-Yi,BaeJae-Ryong,LeeKinam,Chongyong-Soo,HongJinTae,andOhKi-Wan.CordycepinIncreasesNonrapidEyeMovementSleepviaAdenosineReceptorsinRats(2013).Evid-BasedComplementAlternatMed.2013:1-810HuZZ,Park,K.S.,Han,J.Y.etal.Markersinmophine-andcocaineaddictedanimals(2011).BiomolTher,19:52-54. 相关热点
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