个人简历

张邦治，男，1977年生，副教授。 1999年于兰州大学生命科学学院生物化学专业获学士学位， 2005年于兰州大学生命科学学院生物化学与分子生物学专业获博士学位， 2005至2010年任兰州大学生命科学学院讲师。

研究领域

1、多肽药物的设计与合成 2、抗肿瘤多肽药物的构效关系、生理药理活性和作用机制研究

近期论文

1. 王 锐、张邦治、倪京满，“放线菌素D的类似物”，国家发明专利，专利号：ZL200410026093.1 2. Zhang Bangzhi, Wang KR, Yan JX, Zhang W, Song JJ, Ni JM, Wang Rui* In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides, 2010, 31(4): 568-573 (SCI) 3. 张邦治*、王凯荣、王则周、李欣檑、王小丽、倪京满，放线菌素D新类似物的设计、合成与体外抗肿瘤活性研究，高等学校化学学报, 2010, 31(7): 1346-1352 (SCI) 4. Zhang W, Li J, Liu LW, Wang KR, Song JJ, Yan JX, Li ZY, Zhang Bangzhi*, Wang Rui* A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice. Peptides, 2010, 31(10): 1832-1838 (SCI) 5. Jiang XX, Zhang Bangzhi, Zhang YF, Lin L, Yan WJ, Wang Rui* Direct asymmetric Michael addition of thioether-based aryl sulfanyl-propan-2-one to nitroalkenes catalyzed by a chiral amine-thiourea bifunctional organocatalyst. Chirality. 2010, 22(7): 625–634 (SCI) 6. Wang KR, Yan JX, Zhang Bangzhi, Song JJ, Jia PF, Wang Rui* Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer Lett., 2009, 278, 65-72 (SCI) 7. Hong L, Wang L, Chen C, Zhang Bangzhi, Wang Rui* An efficient enantioselective method for asymmetric Friedel-Crafts alkylation of indoles with α,β-unsaturated aldehydes. Adv. Synth. Catal., 2009, 351, 772-778 (SCI) 8. Wang KR1, Zhang Bangzhi1, Zhang W, Yan JX, Li J, Wang Rui* Antitumor effects, cell selectivity and structure-activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides, 2008, 29, 963-968 (SCI) 9. Wang KR1, Zhang Bangzhi1, Zhang W, Yan JX, Li XL, Wang Rui* Potent antitumor effects of a novel actinomycin D analog Leu5AMD. Cancer Lett., 2008, 268, 38-45 (SCI) 10. Chen C, Hong L, Zhang Bangzhi, Wang Rui* Catalytic asymmertric addition of alkynyl zinc reagents to ketones using polymer-supported chiral Schiff-base amino alcohols. Tetrahedron-Asymmetry, 2008, 19, 191-196 (SCI) 11. Liu HM1, Zhang Bangzhi1, Liu XF, Wang CL, Ni JM, Wang Rui* Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg. Med. Chem., 2007, 15, 1694-1702 (SCI) 12. Wang Q, Zhang BangZhi, Hu GW, Chen C, Zhao QY, Wang Rui* Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base–zinc complex. Org. Biomol. Chem., 2007, 5, 1161-1163 (SCI)