个人简历

2017-至今 兰州大学药学院、功能有机分子化学国家重点实验室，教授
2011-2017 兰州大学药学院，副教授
2006-2011 美国梅奥诊所 (导师: Yuan-Ping Pang)，博士后
2001-2006 兰州大学 (导师: 涂永强教授)，理学博士
1997-2001 兰州大学 (导师: 涂永强教授)，理学学士

研究领域

具有生物（药物）活性的小分子的设计与合成，以及天然药物分子全合成和相关合成方法学研究

近期论文

1. Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence. Zhang, Y.; Zheng, T.-L.; Cheng, F.; Dai, K.-L.; Zhang, K.; Ma, A.-J.; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H*.; Tu, Y.-Q.* Chem. Sci. 2020, 11, 3878-3884.
2. A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton. Liu, L.; Lei, L.-S.; Zhan, Z.-S.; Liu, S.-Z.; Wang, Y.-X.; Tu, Y.-Q.*; Zhang, F.-M.; Zhang, X.-M.; Ma, A.-J.; Wang, S.-H.*, Chem. Commun. 2019, 55, 3789-3792
3. Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Liu, L.; Cheng, H.-L.; Ma, W.-Q.; Hou, S.-H.; Tu, Y.-Q.*; Zhang, F.-M.; Zhang, X.-M.; Wang, S.-H.*, Chem. Commun. 2018, 54 , 196-199;
4. Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. Bao, W.; Wang, J.-Q.; Xu, X.-T.; Zhang, B.-H.; Liu, W.-T.; Lei, L.-S.; Liang, H.; Zhang, K.; Wang, S.-H.*, Chem. Commun. 2018, 54, 8194-8197.
5. Construction of the [6,5,7,5] Tetracyclic Core of Calyciphylline A Type Alkaloids via a Tandem Semipinacol Rearrangement/Nicholas Reaction. Shao, H.; Bao, W.; Jing, Z.-R.; Wang, Y.-P.; Zhang, F.-M.; Wang, S.-H.*; Tu, Y.-Q.*, Org. Lett. 2017, 19, 4648-4651;
6. Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles. Zhang, B.-H.; Lei, L.-S.; Liu, S.-Z.; Mou, X.-Q.; Liu, W.-T.; Wang, S.-H.*; Wang, J.; Bao, W.; Zhang, K., Chem. Commun. 2017, 53, 8545-8548;
7. Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis. Zhang, X.-M.; Tu, Y.-Q.*; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H.*, Chem. Soc. Rev. 2017, 46, 2272-2305;
8. Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice. Xu, X.-T.*; Mou, X.-Q.; Xi, Q.-M.; Liu, W.-T.; Liu, W.-F.; Sheng, Z.-J.; Zheng, X.; Zhang, K.; Du, Z.-Y.; Zhao, S.-Q.; Wang, S.-H.*, Bioorg. Med. Chem. Lett. 2016, 26, 5334-5339;
9. The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction. Mou, X.-Q.; Xu, Z.-L.; Xu, L.; Wang, S.-H.*; Zhang, B.-H.; Zhang, D.; Wang, J.; Liu, W.-T.; Bao, W., Org. Lett. 2016, 18, 4032-4035;
10. A Tin(IV) Chloride Promoted Tandem C-O Bond Cleavage/Nazarov Cyclization/Nucleophilic Addition Reaction of 1,1-Disubstituted Allylic Ethers toward the Synthesis of Multisubstituted Indenes. Yang, C.; Xu, Z.-L.; Shao, H.; Mou, X.-Q.; Wang, J.; Wang, S.-H.*, Org. Lett. 2015, 17, 5288-5291;
11. An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted- 1,4,5,6-tetrahydrocyclopenta[b]pyrrole. Mou, X.-Q.; Xu, Z.-L.; Wang, S.-H.*; Zhu, D.-Y.; Wang, J.; Bao, W.; Zhou, S.-J.; Yang, C.; Zhang, D., Chem. Commun. 2015, 51, 12064-12067;
12. Catalytic asymmetric semipinacol rearrangements. Wang, S.-H.; Li, B.-S.; Tu, Y.-Q.*, Chem. Commun. 2014, 50, 2393-2408;
13. Xu, L.; Mou, X.-Q.; Chen, Z.-M.; Wang, S.-H.*, Copper-catalyzed intermolecular azidocyanation of aryl alkenes. Chem. Commun. 2014, 50, 10676-10679;
14. Hou, S.-H.; Tu, Y.-Q.*; Liu, L.; Zhang, F.-M.; Wang, S.-H.*; Zhang, X.-M., Divergent and Efficient Syntheses of the Lycopodium Alkaloids (−)-Lycojaponicumin C, (−)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Angew. Chem. Int. Ed. 2013, 52, 11373-11376;