个人简历
教育背景： 1983年9月至1988年7月 在原兰州医学院临床医学系攻读本科 1988年9月至1991年7月 在原兰州医学院药理学攻读硕士 2003年9月至2006年6月 在兰大生命科学学院攻读博士 工作经历： 1991年7月至1994年7月 兰州医学院药理学教研室 助教 1994年7月至1998年7月 兰州医学院药理学教研室 讲师 1998年7月至2003年12月 兰州医学院药理学教研室 副教授 2003年12月至2004年11月 兰州医学院药理学教研室 教授 2004年11月至今 兰州大学药学院药理学教研室 教授
研究领域
抗肿瘤药理学。 新药临床前药理学。
近期论文
LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI) 。 LI Wenguang, ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin. 2002; 23(8): 727?732. (SCI) WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG.. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941?949. (SCI) Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008；60(2): 179-188. (SCI) WU Yong-jie, LI Wen-guang, ZHANG Zhen-ming and TIAN Xuan. Antioxidative activity of 4-oxy and 4-hydroxy nitroxides in tissues and erythrocytes from rats. cta Pharmacologica Sinica. 1997; 18(6):510-514 XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247?1257. (SCI) XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect and reverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309?318. (SCI) XiaoYu ZHANG, WenGuang LI, YongJie WU and MingTang GAO. Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice. J. Pharmacy Pharmacol. 2005: 57(8): 1043?1052. (SCI) XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432?438. (SCI) TIAN Xuan, ZHANG Fu-min and LI Wen-guang. Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congener. Life Sciences. 2002; 70:2433-2443 WANG Jun-zhi, BAI De-cheng, RAO Chun-ming, LI Wen-guang, GAO Ming-tang, WANG Xiao-qi and WU Yong-jie. Effects of 2.5s mouse nerve growth factor on regeneration of injured sciatic nerves in mice and rats. Acta Pharmacologica Sinica. 1997; 18(6):501-504 ZHANG Yi, WANG Jun-zhi, WU Yong-jie and LI Wen-guang. Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism. Acta Pharmacologica Sinica. 2002; 23(5):439-444 XUE Xiao-chang, WU Yong-jie, GAO Ming-tang, LI Wen-guang, ZHAO Ning, WANG Zen-glu, BAO Chun-jie, YAN Zhen and ZHANG Ying-qi. Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats. World J. Gastroenterol. 2004; 10(7):1032-1036 Xiaoyu ZHANG, Decheng BAI, Yongjie WU, Wenguang LI and Naifa LIU. Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533?538. (SCI) WANG Jun-zhi, WU Yong-jie, RAO Chun-ming, GAO Ming-tang and LI Wen-guang. Effect of recombinant human basic fibroblast growth factor on stomach ulcers in rats and mice. Acta Pharmacologica Sinica. 1999; 20(8):763-768 ZHANG XiaoYu, LI WenGuang, ZHENG TianZhen and LI Wei. Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals. Chin J Appl Physiol. 2005; 21(4): 383-386. (CSCD) ZHANG XiaoYu, LI WenGuang, GAO MingTang and TIAN Xuan. Protectective effect on injured myocardial cells of proanthocyanidins in vitro. Pharmacol Clin Chin Materia Med. 2001; 17(6): 14-16.(CSCD) ZHANG XiaoYu, GAO MingTang, LI WenGuang, TIAN Xuan and ZHU JuHua. The anti-lipoperoxidative effect of grape seed extract in vitro. Advanced in Free Badical Life Sciences. 1999; 7: 116-120. ZHANG XiaoYu, ZHANG YongPing and LI WenGuang. Anti-tumor activity of lanthanum nitrate Complexes with bis(2-pyridyl-N-Oxide)disulphide in vitro. J. Lanzhou University ( Natural Sci). 2004; 40Supp: 34?36. .(CSCD) ZHANG XiaoYu, LI WenGuang, WU YongJie and GAO MingTang. CHL chromosome aberration test of proanthocyanidinsfrom grape seeds. J Lanzhou University ( Natural Sci). 2002; 38(6) Supp: 15-17. .(CSCD) LI WenGuang, ZHANG XiaoYu and WU YongJie. Effect of podophyllic acid hydrozide piperidingyloxy and its derivatives on MDA formation. Chin Pharmacol Bull. 1997; 13(5): 422-424. .(CSCD)
