个人简历

1986年9月至1990年6月，兰州大学生物系植物生理专业，理学学士学位。 1990年6月至1997年8月，甘肃省科学院生物研究所。 1997年9月至2000年6月，兰州大学生命科学学院生物化学与分子生物学系，硕士研究生，理学硕士学位。 2000年9月至2003年6月，兰州大学生命科学学院生物化学与分子生物学研究所，博士研究生，理学博士学位。 2000年7月至今，在兰州大学生命科学学院生物化学与分子生物学研究所从事教学与科研工作。

研究领域

主要从事手性药物与多肽合成法放学研究。我们研究组现在的兴趣主要集中于：（1）手性药物的绿色与原子经济性相关的不对称催化合成方法学研究；（2）不对称格式反应合成手性药物及其中间体；（3）高级结构相关酶模拟物的合成与催化活性研究。

近期论文

1. Ma, Xiao; Da, Chao-Shan*; Yi, Lei; Jia, Ya-Ning; Guo, Qi-Peng; Che, Li-Ping; Wu, Feng-Chun; Wang, Jun-Rui; Li, Wei-Ping. Highly efficient Primary Amine Organocatalysts for the direct asymmetric aldol reaction in brine. Tetrahedron: Asymmetry 2009, 20, 1419-1424. 2.Wu, Feng-Chun; Da, Chao-Shan*; Du, Zhi-Xue; Guo, Qi-Peng; Li, Wei-Ping; Yi, Lei; Jia, Ya-Ning; Ma, Xiao. N-Primary-Amine-Terminal β-Turn Tetrapeptides as Organocatalysts for Highly Enantioselective Aldol Reaction. J. Org. Chem. 2009, 74, 4812-4818. 3.Jia, Ya-Ning; Wu, Feng-Chun; Ma, Xiao; Zhu, Gong-Jian; Da, Chao-Shan*. Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine. Tetrahedron Lett. 2009, 50, 3059-3062. 4.Da, Chao-Shan*; Che, Li-Ping; Guo, Qi-Peng; Wu, Feng-Chun; Ma, Xiao; Jia, Ya-Ning. 2,4-Dinitrophenol as an effective cocatalyst: greatly improving the activities and enantioselectivities of primary amine organocatalysts for asymmetric aldol reactions. J. Org. Chem. 2009, 74, 2541-2546. 5.Yang, Ren-Yong; Da, Chao-Shan*; Yi, Lei; Wu, Feng-Chun; Li, Hong. Asymmetric conjugate addition of unmodified propionaldehyde to β-nitrostyrenes catalyzed by readily available proline-based dipeptidols. Lett. Org. Chem. 2009, 6, 44-49. 6.Li, Hong; Da, Chao-Shan*; Xiao, Yu-Hua; Li, Xiao; Su, Ya-Ning. Direct Asymmetric Aldol Reaction of Aryl Ketones with Aryl Aldehydes Catalyzed by Chiral BINOL-Derived Zincate Catalyst. J. Org. Chem. 2008, 73, 7398-7401. 7.Han, Zhi-jian; Da, Chao-shan; Qiu, Li; Ni, Ming; Zhou, Yi-feng; Wang, Rui. The natural amino acid derived chiral sulfonamide ligands in the catalytic asymmetric addition of phenylacetylene to aldehydes. Lett. Org. Chem. 2006, 3, 143-148. 8.Da, Chao-shan*; Ni, Ming; Han, Zhi-jian; Yang, Fan; Wang, Rui. Novel non-azacyclo 1,2-amino alcohols derived from phenylalanine and highly enantioselective addition of diethylzinc to aryl aldehydes. J. Mol. Catal. A: Chem. 2006, 245, 1-7. 9.Ni, Ming; Wang, Rui; Han, Zhi-jian; Mao, Bin; Da, Chao-shan; Liu, Lei; Chen, Chao. Synthesis of new C2-symmetrical bissulfonamide ligands and application in the enantioselective addition of alkynylzinc to aldehydes and ketones. Adv. Synth. Catal. 2005, 347, 1659-1665. 10.Han, Zhi-jian; Da, Chao-shan; Xu, Zhao-qing; Ni, Ming; Wang, Rui. The asymmetric addition of phenylacetylene to aldehydes catalyzed by L-leucine derived chiral sulfonamide alcohol ligands. J. Mol. Catal. A.: Chem. 2005, 236, 32-38. 11.Kang, Yong-feng; Wang, Rui; Liu, Lei; Da, Chao-shan; Yan, Wen-jin; Xu, Zhao-qing. Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral oxazolidine ligands. Tetrahedron Lett. 2005, 46, 863-865. 12.Da, Chao-Shan; Xin, Zhuo-Qun; Xiao, Yi-Nan; Wang, Heng-Shan; Su, Wu; Yang, Fan; Wang, Rui. 新的含大体积取代基的β-氨基醇配体的合成及在二乙基锌对芳香醛的不对称加成反应中的应用, 有机化学 2004, 24, 943-945. 13.Zhou, Yi-feng; Wang, Rui; Xu, Zhao-qing; Yan, Wen-jin; Liu, Lei; Gao, Yan-feng; Da, Chao-shan. Boc-L-proline as a new chiral ligand for enantioselective phenylacetylene addition to aromatic aldehydes. Tetrahedron: Asymmetry 2004, 15, 589-591. 14.Xu, Zhaoqing; Wang, Rui; Xu, Jiangke; Da, Chao-shan; Yan, Wen-jin; Chen, Chao. Highly enantioselective addition of phenylacetylene to aldehydes catalyzed by a β-sulfonamide alcohol-titanium complex. Angew. Chem., Int. Ed. 2003, 42, 5747-5749. 15.Wang, Heng-Shan; Da, Chao-Shan; Xin, Zhuo-Qun; Su, Wu; Xiao, Yi-Nan; Liu, Da-Xue; Wang, Rui. Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Ni(acac)2 and chiral β-amino alcohols. Chin. J. Chem. 2003, 21, 1105-1107. 16.Da, Chao-Shan; Wei, Jie; Dong, Shou-Liang; Xin, Zhuo-Qun; Liu, Da-Xue; Xu, Zhao-Qin; Wang, Rui. Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide. Synth.Commun. 2003, 33, 2787-2792 17.Da, Chao-shan; Han, Zhi-jian; Ni, Ming; Yang, Fan; Liu, Da-xue; Zhou, Yi-feng; Wang, Rui. A convenient synthesis of piperidine-based β-amino alcohols from l-Phe and highly enantioselective addition of diethyl zinc to aldehydes. Tetrahedron: Asymmetry 2003, 14, 659-665. 18.Xin, Zhuo-qun; Da, Chao-shan; Dong, Shou-liang; Liu, Da-xue; Wei, Jie; Wang, Rui. A novel method for the synthesis of (R)-2,2'-dihydroxy-1,1'-binaphthyl-3,3'-dicarboxylic acid by asymmetric oxidative coupling of a chiral β-naphthol derivative catalyzed by CuCl. Tetrahedron: Asymmetry 2002, 13, 1937-1940. 19.Liu, Da-Xue; Zhang, Li-Cheng; Wang, Quan; Da, Chao-Shan; Xin, Zhuo-Qun; Wang, Rui; Choi, Michael C. K.; Chan, Albert S. C. The application of chiral aminonaphthols in the enantioselective addition of diethylzinc to aryl aldehydes. Org. Lett. 2001, 3, 2733-2735.