个人简历

张书圣，男，1966年3月生，中共党员，博士，教授，博士生导师。1999年3月毕\r
业于南京大学化学系获博士学位，导师为陈洪渊院士、焦奎教授，曾任青岛科技大学化学与分子工程学院院长。1999年10月晋升为教授，2002年9月被南京工业大学遴选为博士生导师，2003年9月被青岛科技大学遴选为博士生导师，2002年11月被鲁南制药股份有限公司聘为博士后工作站指导教师。现指导在读博士研究生9人，硕士研究生10人。长期以来一直从事教学、科研工作。 2003年5月被聘为山东省省级学科带头人；2003年12月获山东省优秀青年知识分子荣誉称号；2003年1月获青岛市专业技术拔尖人才荣誉称号；2006年3月获青岛市十大杰出青年荣誉称号；2006年3月获2山东省高校优秀共产党员荣誉称号；2006年9月获第七届山东高校十大优秀教师荣誉称号。\r
2010年4月获山东省自然科学二等奖（首位）；2009年3月获山东省省级教学成果一等奖（首位）；2008年4月获山东省自然科学二等奖（首位）；2007年4月获山东省科技进步二等奖（首位）；2002年10月获山东省第七届青年科技奖，2013年获教育部自然科学二等奖(第一位）。\r
2011年获青岛市优秀共产党员荣誉称号；2011年11月，作为团队带头人，生化分析团队获批为教育部“长江学者及创新团队发展计划”创新团队；2010年享受国务院颁发政府特殊津贴；2010年10月，作为团队带头人，应用化学团队获批为青岛市优秀创新团队；2009年9月获全国优秀教师荣誉称号；2009年4月获青岛市劳动模范称号；2008年10月，作为团队负责人，化工类专业化学系列课程教学团队获批为国家级教学团队；2008年4月获山东省有突出贡献的中青年专家称号；2006年3月和2008年3月两度获得山东省高校优秀共产党员荣誉称号；2006年9月获第七届山东高校十大优秀教师荣誉称号； 2006年3月获青岛市十大杰出青年荣誉称号；2005年1月获教育部新世纪优秀人才称号；2003年1月获青岛市专业技术拔尖人才荣誉称号；2003年5月被聘为山东省省级学科带头人；2003年12月获山东省优秀青年知识分子荣誉称号；2000年10月被评为青岛市优秀教师。\r
2012年7月，调至临沂大学工作。\r
2012年8月，担任山东省首席专家。\r
职务：临沂大学学术部部长兼科技处处长；生态化工教育部重点实验室主任；生态化工国家重点实验室培育基地主任；山东省生化分析重点实验室主任；《分析化学》编委。

研究领域

"""""单分子检测技术研究室\r
靶向药物载体研发与临床验证研究室\r
诊断试剂及试剂盒研究室\r
光电化学仪器研制研究室\r
传感分析研究室\r
分子成像与原位分析研究室"

近期论文

Sai Bi, Yameng Yan, Shuangyuan Hao, Shusheng Zhang*\r
Colorimetric Logic Gates Based on Supramolecular Constructs of DNAzymes Responding to Ion Input Signals\r
Angew. Chem. Int. Ed., 2010, 49(26): 4438~4442（IF=11.829）\r
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Wei Wang, Lin Li, Shufeng Liu, Cuiping Ma, Shusheng Zhang*\r
Determination of physiological thiols by electrochemical detection with piazselenole and its application in rat breast cancer cells 4T-1\r
J. Am. Chem. Soc., 2008, 130: 10846~10847（IF=8.58）\r
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Xuemei Li, Xiaoyan Yang, Shusheng Zhang*\r
Electrochemical enzyme immunoassay using model labels\r
Trends in Anal. Chem., 2008, 27(6): 543~553（IF=6.546）\r
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Kongcheng Hu, Dongxiao Lan, Xuemei Li, Shusheng Zhang*\r
Chronocoulometric Detection of DNA Hybridization Using reporter DNA Probe Modified with Au Nanoparticles Based on porous gold leaf electrode\r
Anal. Chem., 2008, 80: 9124~9130（IF=5.214）\r
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Caifeng Ding, Xiangling Li, Ying Ge, Shusheng Zhang*\r
Ultrasensitive Fluorescence Detection of Telomerase Activity in Cancer Cells Based on Isothermal Circular Strand-displacement Polymerization Reaction\r
Anal. Chem., 2010, 82 (7): 2850~2855（IF=5.214）\r
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Sai Bi, Li Li, Shusheng Zhang*\r
Triggered Polycatenated DNA Scaffolds for DNA Sensors and Aptasensors by a Combination of Rolling Circle Amplification and DNAzyme Amplification\r
Anal. Chem., 2010, 82(22): 9447~9454（IF=5.214）\r
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Guifen Jie, Lei Wang, Jinxin Yuan, Shusheng Zhang*\r
Versatile Electrochemiluminescence Assays for Cancer Cells Based on Dendrimer/CdSe-ZnS-Quantum Dot Nanoclusters\r
Anal. Chem., 2011, doi: 10.1021/ac200383z（IF=5.214）\r
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Shu-sheng Zhang*, Hua Zhong, Cai-feng Ding*\r
Ultrasensitive Flow Injection Chemiluminescence Detection of DNA Hybridization Using signal DNA probe modified with NanoAu and NanoCuS Tags\r
Anal. Chem., 2008, 80(19): 7206~7212（IF=5.214）\r
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Shu-Sheng Zhang*, Jian-ping Xia, Xue-Mei Li*\r
Electrochemical Biosensor for Detection of Adenosine Based on Structure-Switching Aptamer and Amplification with Reporter Probe DNA Modified Au Nanoparticles\r
Anal. Chem., 2008, 80 (22): 8382~8388（IF=5.214）\r
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Shu-sheng Zhang*, Ya-meng Yan, Sai Bi*\r
Design of Molecular Beacon as Signaling Probes for ATP Detection in Cancer Cells Based on Chemiluminescence Resonance Energy Transfer\r
Anal. Chem., 2009, 81(21): 8695~8701（IF=5.214）\r
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Sai Bi, Yameng Yan, Xiaoyan Yang, Shu-sheng Zhang*\r
Gold Nanolabels for New Enhanced Chemiluminescence Immunoassay of Alpha-fetoprotein Based on Magnetic Beads\r
Chem.-Euro. J., 2009, 15: 4704~4709（IF=5.382）\r
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Caifeng Ding, Ying Ge, Shu-sheng Zhang*\r
Electrochemical and Electrochemiluminescence Determination of Cancer Cells Based on Aptamers and Magnetic Beads\r
Chem.-Euro. J., 2010, 16: 10707~10714（IF=5.382）\r
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Hui Zhang, Congcong Fang, Shusheng Zhang*\r
Electrochemical Determination of Adenosine Triphosphate in Cancer Cells Amplified with Autonomous Bio-bar-code DNA Machine\r
Chem.-Euro. J., 2010, 16: 12434~12439（IF=5.382）\r
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Guifen Jie, Lei Wang, Shusheng Zhang*\r
Magnetic Electrochemiluminescent Hybrid Nanostructures of Fe3O4/CdSe@CdS-Quantum Dots/ Polyelectrolytes for Highly Efficient Immunosensing of Cancer Biomarker Protein\r
Chem.-Euro. J., 2011, 17: 641~648（IF=5.382）\r
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Hui Zhang, Congcong Fang, Shusheng Zhang*\r
Ultrasensitive Electrochemical Analysis of Two-component Analytes by An Autonomous DNA Machine Worked in Two-cycle Modes\r
Chem.-Euro. J., 2011, 17(27) : 7531~7537（IF=5.476）\r
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Xue-mei Li, Jinming Liu, Shu-sheng Zhang*\r
Electrochemical Biosensor for Simultaneous Analysis of Two Analytes Based on a Dual-Aptamer DNA Sequence\r
Chem. Commun., 2010, 46: 595~597（IF=5.504）\r
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Rui Ren, Cuicui Leng, Shusheng Zhang*\r
A Cell sensor based on aptamer recognition and electrode-based circular strand-replacement DNA polymerization\r
Chem. Commun., 2010, 46: 5758 - 5760（IF=5.504）\r
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Hua Zhong, Xi Lei, Xu Hun, Shu-sheng Zhang*\r
Design of One-to-one Recognition DNA Probe Based on Triple Au Nanoparticles Bio Bar Codes and its Application in the Electrochemical DNA Biosensor\r
Chem. Commun., 2009, 45: 6958~6960（IF=5.504）\r
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Yingshu Guo, Xueping Jia, Shusheng Zhang*\r
DNA cycle amplification device on magnetic microbeads for determination of thrombin based on graphene oxide enhancing signal-on electrochemiluminescence\r
Chem. Commun., 2011, 47(2): 725~727（IF=5.504）\r
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Yingshu Guo, Yuanshun Sun, Shusheng Zhang*\r
Electrochemiluminescence induced photoelectrochemistry for sensing of the DNA based on DNA-linked CdS NPs superstructure with intercalator molecules\r
Chem. Commun., 2011, 47 (5): 1595~1597（IF=5.504）\r
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Sai Bi, Hong Zhou, Shu-sheng Zhang*\r
Ultrasensitive Flow Injection Chemiluminescence Detection of DNA Hybridization Based on Bio-Bar-Code Functionalized Magnetic Nanoparticle Label\r
Chem. Commun., 2009, 37: 5567~5569（IF=5.504）\r
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Sai Bi, Shuangyuan Hao, Li Li, Shusheng Zhang*\r
Bio-Bar-Code Dendrimer-like DNA as Signal Amplifier for Cancerous Cells Assay Using Ruthenium Nanoparticle-Based Ultrasensitive Chemiluminescence Detection\r
Chem. Commun., 2010, 46: 6093~6095（IF=5.504）\r
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Caifeng Ding, Hui Li, Xiangling Li, Shusheng Zhang*\r
A new strategy of photoelectrochemical analysis with light source free based on isoluminol labelled chemiluminescence probe\r
Chem. Commun., 2010, 46(42): 7990~7992（IF=5.504）\r
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Guifen Jie, Ping Liu, Shusheng Zhang*\r
Highly Enhanced Electrochemiluminescence of Novel Gold/Silica/CdSe-CdS Nanostructures for Ultrasensitive Immunoassay of Protein Tumor Marker\r
Chem. Commun., 2010, 46: 1323~1325（IF=5.504）\r
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Sai Bi, Jilei Zhang, Shusheng Zhang*\r
Ultrasensitive and Selective DNA Detection Based on Nicking Endonuclease Assisted Signal Amplification and Its Application in Cancer Cell Detection\r
Chem. Commun., 2010, 46: 5509~5511（IF=5.504）\r
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Chunxiang Li, Juan Lin, Yingshu Guo, Shusheng Zhang*\r
An Electrochemiluminescent Reagent of Cyclometalated Iridium Complex-Based DNA Biosensor and its Application in Cancer Cell Detection\r
Chem. Commun., 2011, 47 (15): 4442~4444（IF=5.787）\r
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Xiaoru Zhang, Shuguo Li, Xia Jin, Shusheng Zhang*\r
New Photoelectrochemical Aptasensor for the Thrombin Detection Based on Functionalized Graphene and CdSe Nanoparticles Multilayers\r
Chem. Commun., 2011, 47 (17): 4929~4931（IF=5.787）