个人简历

2016/01-至今 昆明理工大学，副教授； 2013/10-2015/12 昆明理工大学，讲师； 2012/10-2013/09 中国科学院昆明动物研究所，助理研究员； 2007/09-2012/10 中国科学技术大学，生物化学与分子生物学，博士； 2006/07-2007/09 六安市第二人民医院，神经外科，医师； 2001/09-2006/07 蚌埠医学院，临床医学，医学学士。

研究领域

目前在徐天瑞教授领导的团队从事Raf激酶及其结合蛋白在肺癌发生及过敏反应过程中的作用机理研究。

近期论文

1. An S, Yang Y, Ward R, Liu Y, Guo XX, Xu TR*. A-Raf: A new star of the family of Raf kinases. Crit Rev Biochem Mol Biol. 2015;50(6):520-531. 2. Fang Y, Long C, Bai X, Liu W, Rong M, Lai R*, An S*. Two new types of allergens from the cockroach, Periplaneta americana. Allergy. 2015;70(12):1674-1678. 3. An S, Yang Y, Ward R, Liu Y, Guo XX, Xu TR*. Raf-interactome in tuning the complexity and diversity of Raf function. FEBS J. 2015;282(1):32-53. 4. An S, Shen C, Liu X, Chen L, Xu X, Rong M, Liu Z, Lai R*. Alpha-actinin is a new type of house dust mite allergen. PLoS One. 2013;8(12):e81377. 5. An S, Chen LL, Long CB, Liu XY, Xu XM, Lu XR, Rong MQ, Liu ZG, Lai R*. Dermatophagoides farinae allergens diversity identification by proteomics. Mol Cell Proteomics. 2013;12(7):1818-28. (2013 IF: 7.298). 6. An S, Ma D, Wei JF, Yang X, Yang HW, Yang H, Xu X, He S, Lai R*. A novel allergen Tab y 1 with inhibitory activity of platelet aggregation from salivary glands of horseflies. Allergy. 2011;66(11):1420-1427. 7. Zhang XY, Guo H, Han B, Zhang XM, Huang Y, Yang Y, Liu Y, Guo XX, Hao Q, An S*, Xu TR*. Revealing A-Raf functions through its interactome. Biochim Biophys Acta. 2018;1866(8):849-856. 8. Guo H, Zhang XY, Peng J, Huang Y, Yang Y, Liu Y, Guo XX, Hao Q, An S*, Xu TR*. RUVBL1, a novel C-RAF-binding protein, activates the RAF/MEK/ERK pathway to promote lung cancer tumorigenesis. Biochem Biophys Res Commun. 2018 ;498(4):932-939. 9. An S, Chen L, Wei JF, Yang X, Ma D, Xu X, Xu X, He S, Lu J, Lai R*. Purification and Characterization of two new allergens from the venom of Vespa magnifica. PloS One. 2012;7(2):e31920. 10. Ma D*, Xu X*, An S*, Liu H, Yang X, Andersen JF, Wang Y, Tokumasu F, Ribeiro JM, Francischetti IM, Lai R*. A novel family of RGD-containing disintegrins (Tablysin-15) from the salivary gland of the horsefly Tabanus yao targets αIIbβ3 or αVβ3 and inhibits platelet aggregation and angiogenesis. Thromb Haemost. 2011;105(6):1032-45. 11. Peng J*, An S*, Wang HP, Chen XL, Ning XG, Liu J, Yu XY, Mao X, Xu TR*. Video-assisted thoracoscopic surgery lobectomy for lung cancer versus thoracotomy: a less decrease in sVEGFR2 level after surgery. J Thorac Dis. 2016 ;8(3):323-8. 12. Liu Y, An S, Ward R, Yang Y, Guo XX, Li W, Xu TR. G protein-coupled receptors as promising cancer targets. Cancer Lett. 2016;376(2):226-239. 13. Guo H, An S, Ward RJ, Yang Y, Liu Y, Guo XX, Hao Q, Xu TR. Methods used to study the oligomeric structure of G protein-coupled receptors. Biosci Rep. 2017. pii: BSR20160547. 14. Yang Y, An S, Liu Y, Guo XX, Gao L, Wei JF, Xu TR. Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014). Expert Opin Ther Pat. 2016;26(1):89-106. 15. Xu X, Zhang B, Yang S, An S, Ribeiro JM, Andersen JF. Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5. Sci Rep. 2016;6:36574. 16. Guo XX, An S, Yang Y, Liu Y, Hao Q, Xu TR. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra. Cell Physiol Biochem. 2016;39(1):137-156. 17. Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R. Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanus yao. Allergy. 2011;66(1):101-9. 18. Ma D, Gao L, An S, Song Y, Wu J, Xu X, Lai R. A horsefly saliva antigen 5-like protein containing RTS motif is an angiogenesis inhibitor. Toxicon. 2010;55(1):45-51. 19. Ma D, Wang Y, Yang H, Wu J, An S, Gao L, Xu X, Lai R. Anti-thrombosis repertoire of blood-feeding horsefly salivary glands. Mol Cell Proteomics. 2009;8(9):2071-2079. 20. An S，Lai R. Wasp venom allergens and mechanism of wasp venom allergy. [J]. Chinese Science Bulletin, 2012;57(32): 3031-3038.