个人简历

教育经历\r
2008.09-2012.06 中国药科大学 中药资源与开发 本科\r
2012.09-2017.06 中国药科大学 药理学 博士（硕博连读）\r
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研究工作经历\r
2017.09-至今 江苏海洋大学 药学院教师\r
2017.12-2019.12 江苏省 科技副总\r
2018.08-2019.07 江苏省科技镇长团 灌南县组织部人才办副主任\r
2019.08-2020.07 江苏省科技镇长团 灌南县新集镇副镇长\r
2020.06-至今 江苏海洋大学 药学院实验中心主任\r
2021.10-至今 江苏省海洋药物活性分子筛选重点实验室 常务副主任

研究领域

""长期从事神经退行性疾病的发病机制、蛋白质的翻译后修饰及其在疾病中的作用研究""""

近期论文

Ji J, Xie M, Qian Q, Xu Y, Shi W, Chen Z, Ren D, Liu W, He X, Lv M, Ma J, Liu W, Li A, Liu B*. SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer. Biochem Biophys Res Commun. 2022 Jan 8;587:139-145. doi: 10.1016/j.bbrc.2021.11.099. Epub 2021 Nov 30. PMID: 34872002.\r
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Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B, Tan M. Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ. 2022 Jan;29(1):1-13. doi: 10.1038/s41418-021-00827-7. Epub 2021 Jul 2. PMID: 34215846.\r
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Yang X, Zhi J, Leng H, Chen Y, Gao H, Ma J, Ji J*, Hu Q*. The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis. Phytomedicine. 2021 Jul;87:153571. doi: 10.1016/j.phymed.2021.153571. Epub 2021 Apr 20. PMID: 33994056.\r
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Yu H, Yang X, Zhang J, Yang H, Zhao P, Shen H, Jiang GE, Ji J*, Dong J*, Gao S*. A rapid real-time recombinase polymerase amplification assay for diagnosis of acute hepatopancreatic necrosis disease in shrimp. Acta Biochim Biophys Sin (Shanghai). 2021 Mar 2;53(3):381-384. doi: 10.1093/abbs/gmaa175. PMID: 33404640.\r
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Wan J, Liu S, Sun W, Yu H, Tang W, Liu W, Ji J*, Liu B*. Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression. Cancer Cell Int. 2021 Feb 18;21(1):122. doi: 10.1186/s12935-021-01806-1. PMID: 33602225; PMCID: PMC7890835.\r
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Ji M, Zhao Z, Li Y, Xu P, Shi J, Li Z, Wang K, Huang X, Ji J, Liu W, Liu B. FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer. Cell Death Dis. 2021 Jul 31;12(8):758. doi: 10.1038/s41419-021-04040-9. PMID: 34333526; PMCID: PMC8325689.\r
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Jin M, Duan J, Liu W, Ji J, Liu B*, Zhang M*. Feedback activation of NF-KB signaling leads to adaptive resistance to EZH2 inhibitors in prostate cancer cells. Cancer Cell Int. 2021 Apr 1;21(1):191. doi: 10.1186/s12935-021-01897-w. PMID: 33794893; PMCID: PMC8017762.\r
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Liu B#, Xiang L#, Ji J, Liu W, Chen Y, Xia M, Liu Y, Liu W, Zhu P, Jin Y, Han Y, Lu J, Li X, Zheng M, Lu Y*. Sparcl1 promotes nonalcoholic steatohepatitis progression in mice through upregulation of CCL2. J Clin Invest. 2021 Oct 15;131(20):e144801. doi: 10.1172/JCI144801. PMID: 34651580; PMCID: PMC8516465.\r
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Shen J, Zhu Y, Zhou B, Kong L, Jin Y, Zhang D, Cao Z, Ji J, Li J*. In vitro and in vivo evaluation of a water-in-oil microemulsion of platycodin D. Arch Pharm (Weinheim). 2021 Aug;354(8):e2000497. doi: 10.1002/ardp.202000497. Epub 2021 Apr 12. PMID: 33844326.\r
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Wang J, Tang W, Chen S, Zhang J, Ji J, Dong J, Liu G, Gao S. Rapid and sensitive detection of Vibrio alginolyticus pathogenic strains by real-time recombinase polymerase amplification. Acta Biochim Biophys Sin (Shanghai). 2021 Jul 5;53(7):950-954. doi: 10.1093/abbs/gmab051. PMID: 33871545.\r
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Yang X#, Ji J#, Liu C, Zhou M, Li H, Ye S, Hu Q*. HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2. Int Immunopharmacol. 2020 Jun;83:106383. doi: 10.1016/j.intimp.2020.106383. Epub 2020 Mar 16. PMID: 32193099.\r
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Tong HJ, Shi Y, Ji J, Gao X, Yang DY, DU SL, Li WD, Qin KM*. [Network pharmacology study on potential active components in volatile oil of Dictamni Cortex]. Zhongguo Zhong Yao Za Zhi. 2020 Mar;45(5):1135-1141. Chinese. doi: 10.19540/j.cnki.cjcmm.20191205.201. PMID: 32237457.\r
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Li J#, Ji J#, Xu R, Li Z*. Indole compounds with N-ethyl morpholine moieties as CB2 receptor agonists for anti-inflammatory management of pain: synthesis and biological evaluation. Medchemcomm. 2019 Sep 17;10(11):1935-1947. doi: 10.1039/c9md00173e. PMID: 32952995; PMCID: PMC7478157.\r
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Shi Y , Zhan Y , Shi D , Ji J, et al. Quantitative and chemical fingerprint analysis for the quality evaluation of fructus arctii by HPLC coupled with hierarchical clustering analysis[J]. LATIN AMERICAN JOURNAL OF PHARMACY, 2019, 38(4):643-650.\r
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Jian Y#, Ji J#, Huang Z#, et al. Enantiomers of 3-pentylbenzo [c] thiophen-1 (3 H)-one: preparation and evaluation of anti-ischemic stroke activities[J]. RSC advances, 2016, 6(43): 36888-36897.\r
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Yin W#, Lan L#, Huang Z#, Ji J, Fang J, Wang X, Ji H, Peng S, Xu J, Zhang Y*. Discovery of a ring-opened derivative of 3-n-butylphthalide bearing NO/H2S-donating moieties as a potential anti-ischemic stroke agent. Eur J Med Chem. 2016 Jun 10;115:369-80. doi: 10.1016/j.ejmech.2016.03.044. Epub 2016 Mar 19. PMID: 27031213.\r
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Chen T., Gao J, Xiang P, Chen Y, Ji J, et al. Treatment with Akebia Saponin D Ameliorates Aβ1–42-Induced Memory Impairment and Neurotoxicity in Rats[J]. Molecules, 2016, 21(3):323.\r
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Chen T, Gao J, Xiang P, Chen Y, Ji J, Xie P, Wu H, Xiao W, Wei Y, Wang S, Lan L, Ji H, Yan T*. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. Int Immunopharmacol. 2015 Jun;26(2):338-48. doi: 10.1016/j.intimp.2015.04.001. Epub 2015 Apr 15. PMID: 25887267.\r
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Bo W, Wen Li, Ji J, Hui ji*. The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia/reperfusion injury in rats[J]. Atherosclerosis, 2014, 235(2): 318-327.\r
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Hu QH, Zhu JX, Ji J, Wei LL, Miao MX, Ji H*. Fructus Gardenia Extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3. Molecules. 2013 Jul 29;18(8):8976-93. doi: 10.3390/molecules18088976. PMID: 23899832; PMCID: PMC6269767.