郑何平
近期热点
资料介绍
个人简历
2001年本科毕业于中国科技大学,获得生物科学理学学士学位和计算机技术科学工学学士学位。同年考入弗吉尼亚大学分子生理学与生物物理学系, 2009年获得哲学博士学位。同年于弗吉尼亚大学Wladek Minor教授实验室从事博士后研究,2013年在弗吉尼亚大学任研究科学家,2019年加入湖南大学生物学院,聘为教授、岳麓学者。 教育背景 2001年8月-2009年8月,美国弗吉尼亚大学,哲学博士,导师:Wladek Minor教授; 1998年9月-2000年7月,中国科学技术大学计算机技术科学学院,工学学士; 1996年9月-2001年7月,中国科学技术大学生命科学学院,理学学士。 工作履历 2019年2月至今,湖南大学生物学院,教授,岳麓学者,博士生导师; 2013年10月-2019年2月,美国弗吉尼亚大学,研究科学家,导师:Wladek Minor教授; 2009年8月-2013年10月,美国弗吉尼亚大学,博士后研究员,导师:Wladek Minor教授。研究领域
1.数据分析软件R及其基本操作软件包,包括但不限于:用于数据操作的dplyr,作图的ggplot2等; 2.人工智能机器学习算法软件包,例如:caret,pandas/scikit-learn,H2O.ai等; 3.集群环境 Proxmox,云共享软件开发,软件容器 Linux container 或者 Docker; 4.关系数据库 PostgreSQL,分布式数据库MongoDB; 5.MVC框架如Django,Ruby on Rails等; 6.网站服务器Nginx和服务器管理环境node.js; 7.基于bootstrap,web components,React JS或者Angular JS的网页开发;基于Objective-C或者Java的手机App应用开发。 实验室的研究方向还包括以X-射线晶体衍射和冷冻电镜技术为主要手段,结合分子生物学、生物化学、细胞生物学、免疫学、生物物理学等多个学科的方法手段,研究金属结合蛋白以及金属药物与蛋白复合物的结构,阐明其发挥功能的分子机制,并将其应用到诊断治疗、培育养殖上面去。例如:(a)锌依赖性金属蛋白酶SAS1B:该蛋白在卵细胞和癌细胞表面有特异表达,可以作为癌细胞的天然标记蛋白,所以SAS1B 抗体可作为抗癌药物的给药载体。(b)人体血清中转运小分子的白蛋白(Albumin):该蛋白具有锌的特异结合位点,还有可能参与其他金属小分子的转运,在金属结合和转运中起到重要作用。(c)钙结合蛋白AVIL:该蛋白的表达与横纹肌肉瘤密切相关。(d)来自鲤鱼的43kD 锌结合蛋白ZBP:该蛋白作为细胞表面受体参与细胞粘连(cell adhesion),与鲤鱼的消化道组织中经常发现极高浓度的锌有关。近期论文
1.Handing KB, Niedzialkowska E, Shabalin IG, Kuhn ML, Zheng H*, Minor W* (2018) Characterizing metal-binding sites in proteins with X-ray crystallography. Nat Protoc 13: 1062-1090 Times cited: 3 [Pub Med ID: 29674755] F1000 Recommended Publication 2.Hou J, Zheng H*, Tzou WS, Cooper DR, Chruszcz M, Chordia MD, Kwon K, Grabowski M, Minor W* (2018) Differences in substrate specificity of V. cholerae FabH enzymes suggest new approaches for the development of novel antibiotics and biofuels. FEBS J. 285: 2900-2921 [Pub Med ID: 29917313] 3.Porebski PJ, Sroka P, Zheng H, Cooper DR, Minor W (2018) Molstack-Interactive visualization tool for presentation, interpretation, and validation of macromolecules and electron density maps. Protein Sci. 27: 86-94 Times cited: 9 [Pub Med ID: 28815771] 4.Zhang J, Zhu Y, Shi Y, Han Y, Liang C, Feng Z, Zheng H, Eng M, Wang J (2017) Fluoride-Induced Autophagy via the Regulation of Phosphorylation of Mammalian Targets of Rapamycin in Mice Leydig Cells. J Agric. Food Chem. 65: 8966-8976 Times cited: 6 [Pub Med ID: 28927274] 5.Zheng H, Cooper DR, Porebski PJ, Shabalin IG, Handing KB, Minor W (2017) CheckMyMetal: a macromolecular metal-binding validation tool. Acta Crystallogr D Struct Biol 73: 223-233 Times cited: 34 [Pub Med ID: 28291757] 6.Zheng H, Langner KM, Shields GP, Hou J, Kowiel M, Allen FH, Murshudov G, Minor W (2017) Data mining of iron(II) and iron(III) bond-valence parameters, and their relevance for macromolecular crystallography. Acta Crystallogr D Struct Biol 73: 316-325 Times cited: 4 [Pub Med ID: 28375143] 7.Zheng H, Porebski PJ, Grabowski M, Cooper DR, Minor W (2017) Databases, Repositories, and Other Data Resources in Structural Biology. Methods Mol. Biol. 1607: 643-665 [Pub Med ID: 28573593] 8.Zhang J, Zhang Y, Liang C, Wang N, Zheng H, Wang J (2016) Choline supplementation alleviates fluoride-induced testicular toxicity by restoring the NGF and MEK expression in mice. Toxicol Appl Pharmacol. 310: 205-214 Times cited: 2 [Pub Med ID: 27664006] 9.Grabowski M, Langner KM, Cymborowski M, Porebski PJ, Sroka P, Zheng H, Cooper DR, Zimmerman MD, Elsliger MA, Burley SK, Minor W (2016) A public database of macromolecular diffraction experiments. Acta Crystallogr D Struct Biol 72: 1181-1193 Times cited: 26 [Pub Med ID: 27841751] 10.Hou J, Zheng H, Chruszcz M, Zimmerman MD, Shumilin IA, Osinski T, Demas M, Grimshaw S, Minor W (2015) Dissecting the Structural Elements for the Activation of β-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae. J. Bacteriol. 198: 463-76 Times cited: 6 [Pub Med ID: 26553852] 11.Zheng H, Mandal A, Shumilin IA, Chordia MD, Panneerdoss S, Herr JC, Minor W (2015) Sperm Lysozyme-Like Protein 1 (SLLP1), an intra-acrosomal oolemmal-binding sperm protein, reveals filamentous organization in protein crystal form. Andrology 3: 756-71 Times cited: 2 [Pub Med ID: 26198801] 12.Zheng H, Shabalin IG, Handing KB, Bujnicki JM, Minor W (2015) Magnesium-binding architectures in RNA crystal structures: validation, binding preferences, classification and motif detection. Nucleic Acids Res. 43: 3789-801 Times cited: 32 [Pub Med ID: 25800744] 13.Zheng H, Handing KB, Zimmerman MD, Shabalin IG, Almo SC, Minor W (2015) X-ray crystallography over the past decade for novel drug discovery - where are we heading next? Expert Opin Drug Discov 10: 975-89 Times cited: 21 [Pub Med ID: 26177814] 14.Zheng H, Hou J, Zimmerman MD, Wlodawer A, Minor W (2014) The future of crystallography in drug discovery. Expert Opin Drug Discov 9: 125-37 Times cited: 20 [Pub Med ID: 24372145] 15.Zheng H, Chordia MD, Cooper DR, Chruszcz M, Müller P, Sheldrick GM, Minor W (2014) Validation of metal-binding sites in macromolecular structures with the CheckMyMetal web server. Nat Protoc 9: 156-70 Times cited: 131 [Pub Med ID: 24356774] 16.Domagalski MJ, Zheng H, Zimmerman MD, Dauter Z, Wlodawer A, Minor W (2014) The quality and validation of structures from structural genomics. Methods Mol. Biol. 1091: 297-314 Times cited: 9 [Pub Med ID: 24203341] 17.Luo HB, Knapik AA, Petkowski JJ, Demas M, Shumilin IA, Zheng H, Chruszcz M, Minor W (2013) Biophysical analysis of the putative acetyltransferase SACOL2570 from methicillin-resistant Staphylococcus aureus. J. Struct. Funct. Genomics 14: 97-108 Times cited: 1 [Pub Med ID: 23963951] 18.Hou J, Wojciechowska K, Zheng H, Chruszcz M, Cooper DR, Cymborowski M, Skarina T, Gordon E, Luo H, Savchenko A, Minor W (2012) Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68: 632-7 Times cited: 1 [Pub Med ID: 22684058] [Pub Med Central ID: PMC3370898] 19.Zheng H, Filippova EV, Tkaczuk KL, Dworzynski P, Chruszcz M, Porebski PJ, Wawrzak Z, Onopriyenko O, Kudritska M, Grimshaw S, Savchenko A, Anderson WF, Minor W (2012) Crystal structures of putative phosphoglycerate kinases from B. anthracis and C. jejuni. J. Struct. Funct. Genomics 13: 15-26 Times cited: 3 [Pub Med ID: 22403005] 相关热点
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