研究领域

1 钙释放通道蛋白的氧化还原机制研究
2 离子通道蛋白自由巯基数量的估测和与门控状态间的关系探讨‚调控剂电子传递性质和对通道门控的调控性质间的关
3 GSH/GSSG和NADH/NAD+氧化还原电势对Ryanodine receptor （RyR）的氧化还原调控的作用
4 氧化还原调控剂对通道的调控过程中的氧自由基 的产生和作用机制
5 硒和锌等微量元素对Ryanodine receptor的调控及其机制
6 电磁场辐射对EGFR和insulin的信号转导机制的影响、对钙信号通路的 影响‚与EGFR-细胞骨架信号通道的影响。

近期论文

1. Michael J. Jurynec‚ Ruohong Xia ‚ John J. Mackrill ‚ Derrick Gunther‚ Thomas Crawford ‚ Kevin M. Flanigan. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proceedings of the National Academy of Sciences of the United State of America （PNAS）‚ 2008‚ 105(34): 12485–12490.
2. Caili Jia‚ Zhenjie Zhou‚ Renchen Liu‚ Shude Chen‚ Ruohong Xia*. EGF receptor clustering is induced by a 0.4mT power frequency magnetic field and blocked by the EGF receptor tyrosine kinase inhibitor PD153035. Bioelectromagnetics. 2007.28（3）197-207.
3. Li LJ‚ Dai YW‚ Xia RH‚ Chen S‚ Qiao D. Pulsed electric field exposure of insulin induces anti-proliferative effects on human hepatocytes. Bioelectromagnetics. 2005‚(8):639-47.
4. Ologo RO‚ Xia RH‚ Abramson JJ. Spectrophotometric and fluorometric assay of superoxide ionusing 4-Chloro-7- nitrobenzo-2-oxa-1‚3-diazole. Analytical Biochemistry. 2005. 339 .338–344.
5. Xia‚ Ruohong; Ganther‚ Howard E.; Egge‚ Adam; Abramson‚ Jonathan J. Selenium compounds modulate the calcium release channel/ryanodine receptor of rabbit skeletal muscle by oxidizing functional thiols. Biochem Pharmacol. 2004‚Jun 1;67(11):2071-9. (SCI: 2.993).
6. Xia‚ Ruohong‚ et al. Skeletal muscle sarcoplasmic reticulum contains a NADH dependent oxidase that generates superoxide. Am. J. Physiol. Cell Physiol. 2003‚ 285(1):C215-21
7. Xia‚ R‚ Chen‚ K.‚ Ganther‚ H.E.‚ Egge‚ A‚ Zhu‚ PH‚ and Abramson‚ J.J. Selenium containing compounds modulate the Ca2+ release mechanism/ ryanodine receptor of skeletal muscle sarcoplasmic reticulum. Biophys. J. 84‚ 109A (2003). (SCI: 4.463)
8. Xia‚ Ruohong‚ et al. Skeletal muscle ryanodine receptor is a redox sensor with a well defined redox potential that is sensitive to channel modulators. J. Biol. Chem. 2000‚275（47）36565－36561.
9. Xiao-Fang Hu‚ Ke-Ying Chen‚ Ruohong Xia‚ et al. Modulation of the Interactions of Isolated Ryanodine Receptors of Rabbit Skeletal Muscle by Na+ and K+. Biochemistry 2003‚ 42‚ 5515-5521..
10. Xia‚ R.‚ Gnall‚ L.‚ Cutler‚ K.‚ and Abramson‚ J.J. Skeletal Muscle Sarcoplasmic Reticulum Contains a NADH Dependent Oxidase that Generates Superoxide and Activates the Ryanodine Receptor. Biophys. J. 84‚ 18A (2003). (SCI: 4.463)
11. Wang H‚ Zhu HF‚ Xia R‚ Zhou ZN‚ Zhu PH. Effect of intermittent and continuous hypoxia on ryanodine receptors of rat heart. Life Sci. 2003 Sep 12;73(17):2151-60.
12. Xia‚ Ruohong‚ et al. Biphasic modulation of ryanodine binding to sarcoplasmic reticulum vesicles of skeletal muscle by Zn2+ ions. Biochem. J. 2000‚ 345‚ 279-286. (SCI: )
13. Wang‚ Hui; Chen‚ Keying; Xia‚ Ruohong; Zhu‚ Peihong. Inhibition of Ryanodine Binding to Sarcoplasmic Reticulum Vesicles of Cardiac Muscle by Zn2+ Ions. Cellular Physiology and Biochemistry 2001‚11:83-92.
14. Wei‚ Feng; Liu‚Guohua; Xia‚ Ruohong; et al. Site-selective modification of hyperreactive cysteines of ryanodine receptor complex by quinones. Mol. Pharm. May 1999‚ 55(5): 821-831.