研究领域

生物医学   免疫学

近期论文

1.Xiong Qingqing †，Huang Hongjun†，Wang Ning，Chen Ruoyu，Chen Naiyang，Han Honghui，Wang Qin，Siwko Stefan，Liu Mingyao，Qian Min and Du Bing*．Metabolite-Sensing G Protein Coupled Receptor TGR5 Protects HostFrom Viral Infection Through Amplifying Type I Interferon Responses．Frontiers in Immunology，2018，Oct 2，9:2289 2.Hongjun Huang#，Qingqing Xiong#， NingWang#，Ruoyu Chen，Hua Ren，Stefan Siwko，Honghui Han，Mingyao Liu，Min Qian* and Bing Du*．Kisspeptin/GPR54 signaling restricts antiviral innate immuneresponse through regulating calcineurin phosphatase activity．Science Advances，2018，Vol. 4, no. 8, eaas9784 3.Tan Binghe，Xiujuan Shi，Jie Zhang，Juliang Qin，Na Zhang，Hua Ren，Qian Min，Stefan Siwko，Kendra Carmon，Qingyun Liu，Honghui Han，Bing Du* and Mingyao Liu*．Inhibitionof Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophagepolarization．CancerResearch，2018，Jul 2 1．Yaru Shi , Zhenlong Li , RanChen , Jiang Zhang , Xuefei Hu , Cong He , Qiong Su , Hongdou Ma , Hua Ren ,Min Qian , Shufang Cui，Wenzheng Jiang*．Immethridine, histamine H3-receptor (H3R) agonist, alleviatedexperimental autoimmune encephalomyelitis via inhibiting the function ofdendritic cells．Oncotarget，2017，8：75038-75049. 2．Hongjun Huang，Na Zhang，Qingqing Xiong，Ruoyu Chen，Chengfei Zhang，Ning Wang，Li Wang，Hua Ren，Mingyao Liu，Min Qian，Bing Du*．Elimination of GPR146-mediated antiviral function throughIRF3/HES1-signaling pathway．Immunology，2017，Sep，152(1)：102-114 3．Xiaoyu Zhang，Juliang Qin，Junyan Zou，Zhangsheng Lv，Binghe Tan，Jueping Shi，Yihan Zhao，Hua Ren，Mingyao Liu，Min Qian，Bing Du*．Extracellular ADP facilitates monocyte recruitment inbacterial infection via ERK signaling．Cellular &Molecular Immunology，2016，Nov 21， 4．Qin Juliang，Zhang Xiaoyu，Wang Ziqiang，Li Jinju，Zhang Zhen，Ren Hua，Qian Min，Du Bing*．Presenilin 2 deficiency facilitates Aβ-induced neuroinflammationand injury by upregulating P2X7 expression．SCIENCE CHINA LifeSciences，2016，Dec 21 5．Xiaobin Ma，Xinhua Pan，Yinglei Wei，Binhe Tan，Linli Yang，Hua Ren，Min Qian，Bing Du*．Chemotherapy-induced uridine diphosphate release promotesbreast cancer metastasis through P2Y6 activation．Oncotarget，2016，7(20)：29036-29050 6．Xiaoyu Zhang，Juliang Qin，Yihan Zhao，Jueping Shi，Rong Lan，Yunqiu Gan，Hua Ren，Bing Zhu，Min Qian，Bing Du*．Long-term ketogenic diet contributes to glycemic control butpromotes lipid accumulation and hepatic steatosis in type 2 diabetic mice．Nutrition Research，2016，36(4):349-58 7．Jueping Shi，Xiaoyu Zhang，Shaoying Wang，Jinjin Wang，Bing Du，Zhugang Wang，Mingyao Liu，Wenzheng Jiang，Min Qian，Hua Ren*．Gpr97 is dispensable for metabolic syndrome but is involved inmacrophage inflammation in high-fat diet-induced obesity in mice．Scientific Report，2016，Apr 19，6:24649. 8．Jueping Shi，Shaoying Wang，Lili Chen，Xiaoyu Zhang，Yihan Zhao，Bing Du，Wenzheng Jiang，Min Qian，Hua Ren*．P2Y6 contributes to ovalbumin-induced allergic asthma by enhancingmast cell function in mice．Oncotarget，2016，Aug 31. 9．Juliang Qin，Guangxu Zhang，Xiaoyu Zhang，Binghe Tan，Zhangsheng Lv，Mingyao Liu，Hua Ren，Min Qian，Bing Du*．TLR-activated Gap Junction Channels Protects Mice againstBacterial Infection through Extracellular UDP Release．Journal of Immunology，2016，Feb15，196(4):1790-1798 10．Jinju Li，Guangxu Zhang，Dalong Cheng，Hua Ren，Min Qian，Bing Du*．Molecularcharacterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat. Gene，2015，Apr 25，561(1):115-123 11．Wei Gao，Zhewei Tang，Yi-Fan Zhang，Mingqian Feng，Min Qian，Dimiter S. Dimitrov & Mitchell Ho*．Immunotoxin targeting glypican-3 regresses liver cancer via dualinhibition of Wnt signalling and protein synthesis．Nature Communications，2015，6(3):1-12 12．Shi Jueping，Xiaoning Li，Xiaoyu Zhang，Bing Du，Wenzheng Jiang，Mingyao Liu，Jinjin Wang，Zhugang Wang，Hua Ren，Min Qian*．Gpr97 Is Dispensablefor Inflammation in OVA-Induced Asthmatic Mice．PLoS One，2015，Jul 1，10(7):e0131461 13．Bing Du，Weijia Luo，Ruimei Li，Binghe Tan，Honghui Han，X Lu，Dali Li，Min Qian，Dekai Zhang，Y Zhao，Mingyao Liu*．Lgr4/Gpr48 negatively regulates TLR2/4 associated patternrecognition and innate immunity by targeting CD14 expression．The Journal of Biological Chemistry，2013，May 24；288(21):15131-41 14．Zhao Fang，Meixia Zhang，Zhenghui Yi，Chengping Wen，Min Qian and Tieliu Shi*．Replacements of Rare Herbs and Simplifications of TraditionalChinese Medicine Formulae Based on Attribute Similarities and PathwayEnrichment Analysis．Evidence-BasedComplementary and Alternative Medicine，2013， 2013:136732. . Epub 2013 Feb 21 15．Jiani Du，Xiaoyu Wu，Fengying Long，Jiejun Wen，Wenli Hao，Ran Chen，Xiaobo Kong，Min Qian and Wenzheng Jiang．Improvement in Efficacy of DNA Vaccine Encoding HIV-1 Vif by LIGHTGene Adjuvant．Viral Immunol.，2013，Feb；26(1):68-74. 16．Tang Zhewei, Mingqian Feng,Wei Gao, Yen Phung, Weizao Chen, Amit Chaudhary, Brad St. Croix, Min Qian, Dimiter S. Dimitrov, Mitchell Ho*. A humansingle-domain antibody elicits potent anti-tumor activity by targeting anepitope in mesothelin close to the cancer cell surface. Mol Cancer Therapeutics，2013， Jan 31；12(4): 416-426 17．Tang Zhewei，Min Qian，MitchellHo*．The Role ofMesothelin in Tumor Progression and Targeted Therapy．Anti-cancer Agents inMedicinal Chemistry．2013，13：276-280 18．Zhao Qufei, Qian Yu, Li Ruimei, TanBinghe, Han Honghui, Liu Mingyao, Qian Min* and Du Bing*. Norcantharidin facilitatesLPS-mediated immune responses by up-regulation of AKT/NF-κBsignaling in macrophages. PLOSONE，2012，7(9):e44956 19．Wang Zhiqiang，JiangWei，ZhangZhi，QianMin，DuBing*. Nitidine Chloride inhibits LPS-induced inflammatory cytokines productionvia MAPK and NF-kappaB pathway in RAW 264.7 cells. Journal ofEthnopharmacology．2012，Oct31;144(1):145-50.