研究领域

廖鲁剑教授于2002年12月在美国Bowling Green州立大学获得计算机科学硕士和生物科学/神经生物学博士学位，在美国Emory大学及加州Scripps研究所John Yates实验室从事博士后研究，后以Staff Scientist任职于Scripps 研究所。2012年5月回国任中科院上海生物化学与细胞生物学研究所/国家蛋白质科学研究中心研究员，获中科院上海生科院特殊人才计划支持。2013年8月担任华东师范大学生命医学研究所生物医学教授、博士生导师，建立功能蛋白质组学实验室。主要研究方向为利用蛋白质组学方法结合分子、细胞、动物等手段研究细胞器质量控制在神经退行性疾病发生中的作用。在确定神经退行性疾病主要病变的蛋白组成和定量蛋白质组学新方法探索做出开拓性的工作，

近期论文

Wan H, Tang B*, Liao X, Zeng Q, Zhang Z, Liao L*. Analysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death. Cell Death & Diff. 2017 Dec 12. PMID:29234155 Tan GH, Liu YY, Wang L, et al., Liao LJ, Wu ZY, Xiong ZQ. PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell Res. 2017, doi: 10.1038/cr.2017.128. PMID: 29056747 Wang T, Yu Q, Li J, Hu B, Zhao Q, Ma C, Huang W, Zhuo L, Fang H, Liao L, Eugene Chin Y, Jiang Y. O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency. Nat Cell Biol. 2017, 19(7):833-843. PMID:28628081 Wei W, Mao A, Tang B, Zeng Q, Gao S, Liu X, Lu L, Li W, Du JX, Li J, Wong J*, Liao L*. Large-Scale Identification of Protein Crotonylation Reveals Its Role in Multiple Cellular Functions. J Proteome Res. 2017, 16(4):1743-1752.PMID:28234478 Xu DQ, Wang Z, Wang CY, et al., Liao LJ, Chen Y. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J. 2016, 35(5):496-514. PMID:26834238 Park Y, Jin HS, Lopez J, Lee J, Liao L, Elly C, Liu YC. SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Nat Immunol. 2016 Mar;17(3):286-96. PMID:26829767 Tang B, Wang T, Wan H, Han L, Qin X, Zhang Y, Wang J, Yu C, Berton F, Francesconi W, Yates JR, Vanderklish PW, Liao L*. Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome. Proc Natl Acad Sci U S A. 2015, 112(34):E4697-706. PMID:26307763 Qin X, Zheng C, Yates JR 3rd, Liao L*. Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins. Mol BioSyst. 2014, 10(7):1719-29. PMID:24626860 Li K, Zhou T, Liao L, Yang Z, Wong C, Henn F, Malinow R, Yates JR, Hu H. βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression. Science 2013;341:1016-1020. Jin HS, Liao L, Park Y, Liu YC. Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling. Proc Natl Acad Sci U S A. 2013;110(2):624-9. Sando R 3rd, Gounko N, Pieraut S, Liao L, Yates JR 3rd, and Maximov A. HDAC4 Governs Transcriptional Programs Essential for Synaptic Development and Function. Cell. 2012; 151(4):821-34. Liao L, Sando RC, Farnum JB, Vanderklish PW, Maximov A, and Yates JR 3rd. 15N labeled brain enable quantification of proteome and phosphoproteome in neurons. J Proteome Res. 2012; 11(2):1341-53 Hart JR, Liao L, Yates JR 3rd, Vogt PK. An essential role of signal transducer and activator of transcription 3 in phosphatidylinositol 3-kinase-induced oncogenic transformation. Proc Natl Acad Sci USA. 2011; 108(32):13247-52 Hart JR*, Liao L*, Ueno L, Yates JR 3rd, Vogt PK. Protein expression profiles of C3H 10T1/2 murine fibroblasts and of isogenic cells transformed by the H1047R mutant of phosphoinositide 3-kinase (PI3K). Cell Cycle. 2011; 10(6):971-6 Huang H#, Jeon M#, Liao L#, Yang C, Elly C, Yates JR, and Liu YC. K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling. Immunity. 2010; 33(1):60-70 Liao L#, McClatchy DB#, Yates JR. Primer: shotgun proteomics in neuroscience. (Review) Neuron. 2009; 63(1):12-26 Park SK#, Liao L#, Kim JY, and Yates JR. A computational approach to correct arginine-to-proline conversion in quantitative proteomics. Nature Methods. 2009; 6(3):184-185 Liao L, Park SK, Xu T, Vanderklish PW, and Yates JR. Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice. Proc Natl Acad Sci USA. 2008; 105(40):15281-6 Liao L#, McClatchy DB#, Park SK, Xu T, Lu B and Yates JR. Quantitative analysis of brain nuclear phosphoproteins identifies developmentally regulated phosphorylation events. J Proteome Res. 2008; 7(11):4743-55 知名期刊Phytomedicine，J Ethnopharmacol及国际食品科学知名期刊J Funct Foods颁发的杰出贡献奖。