个人简历

教育背景
2004-2007博士学位吉林大学畜牧兽医学院（分子免疫学方向）
1997-2001硕士学位解放军军需大学军事兽医系（分子细菌学方向）
1986-1991学士学位解放军兽医大学动物医学专业
工作简历
2019/9-长江大学动物科学学院教授
2008/9-吉林大学动物医学学院教授
2004/9-2008/9吉林大学畜牧兽医学院副教授
2007-2009博士后研究中国农业科学院北京畜牧兽医研究所
出访及挂职经历
2010-2011访问学者英国牛津大学Weatherall分子医学研究所人类免疫学组

研究领域

研究方向为人兽共患病病原微生物致病机理及其免疫学防治。主要研究内容为细菌耐药性克服、重要呼吸道病原菌致病因子识别及其与宿主互作机制；抗感染免疫应答、新型疫苗与抗体药物研究。"软件版权登记及专利
1.联合利用抗菌肽和超高压制备细菌菌影的方法及应用，ZL200910067287.9，2012
2.利用抗菌肽制备细菌菌影的方法及应用，ZL200910067286.4，2012
3.人溶菌酶-抗菌肽Catesbeianin-1融合蛋白制备方法及其在防治奶牛乳房炎中的应用，ZL200910067530.7，2012
4.一种快速检测牛奶中金黄色葡萄球菌的方法，ZL200910217881.1，2010
5.灭活肺炎克雷伯菌作为佐剂在动物灭活疫苗中的用途，ZL201410280086.8，2017
6.一种用于裂解大肠杆菌的融合裂解酶，ZL201611202035.9，2019
科研项目
1.IFN-gamma诱导奶牛乳腺上皮细胞精氨酸耗竭的分子机制，31772715，国家自然科学基金委，2018-2021

近期论文

1.WangS,YinB,YuL,DangM,GuoZ,YanG,HuD,GuJ,DuC,FengX,HanW,AdamYY,SunC,BosséJT,LeiL.OverexpressionofAmpCPromotesBacteriophageLysisofAmpicillin-ResistantEscherichiacoli.FrontMicrobiol.2020Jan8;10:2973.
2.ZhangM,CheY,ZhaoS,XiaX,LiuH,LiuJ,WangY,HanW,YangY,ZhouC,LeiL.TGF-β1promotedtheinfectionofbovinemammaryepithelialcellsbyStaphylococcusaureusthroughincreasingexpressionofcells'fibronectinandintegrinβ1.VetMicrobiol.2019Oct;237:108420.
3.QiW,ZhuR,BaoC,XiaoJ,LiuB,SunM,FengX,GuJ,LiY,LeiL.Porcinecircovirustype2promotesActinobacilluspleuropneumoniaesurvivalduringcoinfectionofporcinealveolarmacrophagesbyinhibitingROSproduction.VetMicrobiol.2019Jun;233:93-101.
4.LiuH,JiaL,GuoW,SunY,ZhuR,LiS,QuG,JiangH,WangJ,GuJ,SunC,FengX,HanW,LeiL.DifferentialProteinProfilingofCerebrospinalFluidinPigletswithSevereMeningoencephalitisCausedbyStreptococcussuisType2ComparedtoControls.FrontCellInfectMicrobiol.2018Feb9;8:35.
5.SunY,LiuH,DuR,LiS,QuG,ZhuR,ZhaoS,GuJ,SunC,FengX,HanW,LeiL.CharacteristicComparisonofMeningitisandNon-meningitisofStreptococcussuisinanExperimentallyInfectedPorcineModel.Inflammation.2018Mar;41(2):368-377.
6.YuL,WangS,GuoZ,LiuH,SunD,YanG,HuD,DuC,FengX,HanW,GuJ,SunC,LeiL.Aguard-killerphagecocktaileffectivelylysesthehostandinhibitsthedevelopmentofphage-resistantstrainsofEscherichiacoli.ApplMicrobiolBiotechnol.2018Jan;102(2):971-983.
7.LiuJ,MaQ,YangF,ZhuR,GuJ,SunC,FengX,DuC,LangfordPR,HanW,YangJ,LeiL.Bcellcross-epitopeofPropionibacteriumacnesandActinobacilluspleuropneumoniaselectedbyphagedisplaylibrarycanefficientlyprotectfromActinobacilluspleuropneumoniainfection.VetMicrobiol.2017Jun;205:14-21.
8.QinW,WangL,ZhaiR,MaQ,LiuJ,BaoC,SunD,ZhangH,SunC,FengX,GuJ,DuC,HanW,LangfordPR,LeiL.Apa2H1,thefirstheaddomainofApa2trimericautotransporteradhesin,activatesmousebonemarrow-deriveddendriticcellsandimmunizationwithApa2H1protectsagainstActinobacilluspleuropneumoniaeinfection.MolImmunol.2017Jan;81:108-117.
9.GaoY,WangY,LiY,XiaX,ZhaoS,CheY,SunY,LeiL.TGF-β1promotesbovinemammaryfibroblastproliferationthroughtheERK1/2signallingpathway.CellBiolInt.2016Jul;40(7):750-60.doi:10.1002/cbin.10609.Epub2016May5.
10.WangL,QinW,ZhangJ,BaoC,ZhangH,CheY,SunC,GuJ,FengX,DuC,HanW,RichardPL,LeiL.AdhenhancesActinobacilluspleuropneumoniaepathogenicitybybindingtoOR5M11andactivatingp38whichinducesapoptosisofPAMsandIL-8release.SciRep.2016Apr5;6:24058.
11.XiaX,CheY,GaoY,ZhaoS,AoC,YangH,LiuJ,LiuG,HanW,WangY,LeiL.ArginineSupplementationRecoveredtheIFN-γ-MediatedDecreaseinMilkProteinandFatSynthesisbyInhibitingtheGCN2/eIF2αPathway,WhichInducesAutophagyinPrimaryBovineMammaryEpithelialCells.MolCells.2016May31;39(5):410-7.
12.SunY,LiN,ZhangJ,LiuH,LiuJ,XiaX,SunC,FengX,GuJ,DuC,HanW,LeiL.EnolaseofStreptococcusSuisSerotype2EnhancesBlood-BrainBarrierPermeabilitybyInducingIL-8Release.Inflammation.2016Apr;39(2):718-26.
13.LvM,WangS,YanG,SunC,FengX,GuJ,HanW,LeiL.GenomesequencingandanalysisofanEscherichiacoliphagevB_EcoM-ep3withanovellysin,Lysep3.VirusGenes.2015Jun;50(3):487-97.
14.WangL,QinW,YangS,ZhaiR,ZhouL,SunC,PanF,JiQ,WangY,GuJ,FengX,DuC,HanW,LangfordPR,LeiL.TheAdhadhesindomainisrequiredfortrimericautotransporterApa1-mediatedActinobacilluspleuropneumoniaeadhesion,autoaggregation,biofilmformationandpathogenicity.VetMicrobiol.2015May15;177(1-2):175-83.
15.YangF,MaQ,LeiL,HuangJ,JiQ,ZhaiR,WangL,WangY,LiL,SunC,FengX,HanW.SpecifichumoralimmuneresponseinducedbypropionibacteriumacnescanpreventActinobacilluspleuropneumoniaeinfectioninmice.ClinVaccineImmunol.2014Mar;21(3):407-16.doi:10.1128/CVI.00667-13.Epub2014Jan15.
16.XiaoL,ZhouL,SunC,FengX,DuC,GaoY,JiQ,YangS,WangY,HanW,LangfordPR,LeiL.ApaisatrimericautotransporteradhesinofActinobacilluspleuropneumoniaeresponsibleforautoagglutinationandhostcelladherence.JBasicMicrobiol.2012Oct;52(5):598-607.