个人简历

研究员，博士生导师，成都中医药大学药学院副院长，美国纽约州立大学RNA研究所访问学者。入选国家中组部“万人计划”专家、国家中医药管理局“青年岐黄学者”、 中国科技期刊卓越行动计划项目—首批青年中医药求真学者、四川省学术与技术带头人，四川省中医药管理局学术带头人

研究领域

"""""研究方向为中药药效物质的结构优化、分子网络机制、多维构效关系和创新药物研发。以临床疗效显著的经典中药药效成分为研究对象，融合多层次的药物结构信息与活性数据，系统研究药效成分“构-效-毒”的多维关系，以此开展药物筛选和创新药物设计开发"

近期论文

Han, B.; He, X.-H.; Liu, Y.-Q.; He, G.; Peng, C.*; Li, J.-L.* Asymmetric organocatalysis: an enabling technology for medicinal chemistry. Chemistry Society Review 2021, 50, 1522. IF: 54.564\r
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Li, J.-L.; Liu, Y.-Q.; Zou, W.-L.; Zeng, R.; Zhang, X.; Liu, Y.; Han, B.*; He, Y.; Leng, H.-J.; Li, Q.-Z.* Radical Acylfluoroalkylation of Olefins through N-Heterocyclic Carbene Organocatalysis.Angewandte Chemie-International Edition 2020, 59 (5), 1863. IF: 15.336\r
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Han, B.; Xiao, Y.-C.; Yao, Y.; Chen, Y.-C.* Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles. Angewandte Chemie-International Edition 2010, 49, 10189. IF: 15.336\r
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Han, B.; He, Z.-Q.; Li, J.-L.; Li, R.; Jiang, K.; Liu, T.-Y.; Chen, Y.-C.* Organocatalytic Regio- and Stereoselective Inverse-Electron-Demand Aza-Diels–Alder Reaction of α,β-Unsaturated Aldehydes and N-Tosyl-1-aza-1,3-butadienes. Angewandte Chemie-International Edition 2009, 48, 5474. IF: 15.336\r
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Han, B.; Li, J.-L.; Ma, S.; Zhang, S.-J.; Chen, Y.-C.* Organocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels-Alder Reaction of N-Sulfonyl-1-aza-1,3-butadienes and Aldehydes. Angewandte Chemie-International Edition 2008, 47, 9971. IF: 15.336\r
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Wang, B.; Peng, F.; Huang, W.; Zhou, J.; Zhang, N.; Sheng, J.; Haruehanroengra, P.; He, G.*; Han, B.* Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma, Acta Pharmaceutica Sinica B, 2020, 10,1492 IF: 11.413\r
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Peng, F.; Zhao, Q.; Huang, W.; Liu, S.-J.; Zhong, Y.-J.; Mao, Q.; Zhang, N.; He, G.*; Han, B.* Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process. Green Chemistry 2019, 21 (22), 6179. IF: 10.182\r
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Zhang, X.; Li, Xiang.; Li, J.-L.*; Wang, Q.-W.; Zou, W.-L.; Liu, Y.-Q.; Jia, Z.-Q.; Peng, F.*; Han, B.* Regiodivergent construction of medium-sized heterocycles from vinylethylene carbonates and allylidenemalononitriles. Chemical Science 2020, 11, 2888. IF: 9.825\r
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Liu, S.-J.; Zhao, Q.; Peng, C.; Mao, Q.; Wu, F.; Zhang, F.-H.; Feng, Q.-S.; He, G.; Han, B.* Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation. European Journal of Medicinal Chemistry 2021, 217, 113359. IF: 6.514\r
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Ye, C.; Zhan, N.; Zhao, Q.; Xie, X.; Li, X.; Zhu, H.-P.; Peng, C.; Huang, W.*; Han, B.* Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway. Phytotherapy Research 2021, 1. IF: 5.878\r
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Xie, X.; Xiong, S.-S.; Li, X.; Huang, H.; Wu, F.-B.; Shen, P.-F.; Peng, C.*; G.; He*, Han, B.* Design and organocatalytic synthesis of spirooxindole–cyclopentene–isoxazole hybrids as novel MDM2–p53 inhibitors. Organic Chemistry Frontiers 2021, 8, 1836. IF: 5.281\r
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Zuo, W.-F.; Zhou, J.; Wu, Y.-L.; Fang, H.-Y.; Lang, X.-J.; Li, Y.; Zhan, G.*; Han, B.* Synthesis of spiro(indoline-2,3’-hydropyridazine) via an “on-water” [4 + 2] annulation reaction. Organic Chemistry Frontiers 2021,8, 922. IF: 5.281\r
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Zhao, Q.; Peng, C.; Wang, Y.-T.; Zhan, G.; Han, B.* Recent progress on the construction of axial chirality through transition-metal-catalyzed benzannulation . Organic Chemistry Frontiers 2021, 8, 2772. IF: 5.281\r
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Ai, Y.-Y.; Li, D.-A.; Li, G.; Li, H.-P.; He, X.-H.; Fu, X.-J.; Wang, Y.-T.; Zhan, G.; Han, B.* Asymmetric Synthesis of Spirocyclopentane Oxindoles via [2+3] Annulation with 2-(2-Oxoindolin-3-yl)malononitriles as 1,2-Carbon Bisnucleophiles. Advanced Synthesis & Catalysis. 2021, 363(13), 3283. IF: 5.838\r
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Li, Q.-Z.; Zeng, R.; Han B.*; Li, J.-L.* Single-Electron Transfer Reactions Enabled by N-Heterocyclic Carbene Organocatalysis. Chemistry - A European Journal 2021, 27(10): 3238. IF: 5.236\r
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Zhang, N.; Peng, F.; Wang, Y.; Yang, L.; Wu, F.; Wang, X.; Ye, C.; Han, B.*; He, G.* Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis. International Journal of Biological Sciences 2020, 16, 147. IF: 6.580\r
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Ji, Y.-L.; He, X.-H.; Li, G.; Ai, Y.-Y; Li, H.-P.; Peng C.; Han, B.* Substrate-directed chemo- and regioselective synthesis of polyfunctionalized trifluoromethyl-arenes via organocatalytic benzannulation. Organic Chemistry Frontiers 2020, 7, 563. IF: 5.281\r
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Tang, X.; Zhang, N.; He, G.*; Li, C.-H.; Huang, W.; Wang, X.-Y.; Zhan, G*.; Han, B.* Unconventional [2 + 3] Cyclization Involving [1,4]-Sulfonyl Transfer to Construct Polysubstituted Fluorazones as Inhibitors of Indoleamine 2,3-Dioxygenase 1. Organic Letters 2020, 22, 7909. IF: 6.005\r
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Zhu, H.-P.; Xie, K.; He, X.-H.; Huang, W.; Zeng, R.; Fan, Y.; Peng, C.; He, G.*; Han, B.* Organocatalytic diastereoselective 3+2 cyclization of MBH carbonates with dinucleophiles: synthesis of bicyclic imidazoline derivatives that inhibit MDM2-p53 interaction. Chemical Communications 2019, 55 (76), 11374. IF: 6.222\r
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Xie, X.; Xiang, L.; Peng, C.*; Han, B.* Catalytic Asymmetric Synthesis of Spiropyrazolones and their Application in Medicinal Chemistry. Chemical Record 2019, 19 (11), 2209. IF: 6.771