个人简历

一、学习经历： 1996.09—2000.07 哈尔滨工业大学—高分子材料科学与工程 工学学士 2000.09—2002.07 哈尔滨工业大学—应用化学系 高分子材料专业 工学硕士 2002.09—2006.04 哈尔滨工业大学—应用化学系 高分子材料专业 工学博士 二、工作经历 (Background of Work)： 2006.04—2008.07 中国科学院长春应用化学研究所—生物材料组博士后 2008.11—2012.05 长春理工大学—生命科学与技术学院副教授 2012.05—2014.08 长春理工大学—材料科学与工程学院副教授 2014.08—至今 长春理工大学—材料科学与工程学院 教授、博导

研究领域

一、纳米药物载体材料的设计与制备 合成新型的的两亲性嵌段共聚物将其自组装成纳米粒子，用来装载药物和基因制备成新型的药物或基因载体，并进行肿瘤靶向性改性，获得智能靶向载药纳米体系；合成纳米无机材料微球，用做药物载体，实现治疗介导与示踪诊疗一体化。 二、光动力学疗法和光动力抗菌 以大环化合物酞菁、卟啉等为研究对象，通过化学修饰将其水溶性和靶向性处理，并制备纳米载体装载光敏剂进行光动力学治疗恶性肿瘤。以天然高分子水凝胶为载体，担载亚甲基蓝、阳离子卟啉等光敏剂，通过光照产生单线态氧杀死细菌，实现光动力抗菌，是未来对抗无抗生素可以抑制的超级细菌的一种治疗手段。 三、基因载体 以阳离子聚合物为研究对象，以聚氨基酸为研究重点，合成具备高转染效率，低毒性的超枝化阳离子聚合物。研究基因载体在担载基因进行基因治疗的过程，研究治疗基因和药物共载治疗肿瘤的效果。根据纳米粒子在体内传输过程中所遇到的屏障，设计具有电荷翻转的遮蔽体系，获得能够有效对抗恶性肿瘤药物传输体系。

近期论文

Chang Xu, Xiuwen Guan, Lin Lin, Qing Wang, Bo Gao, Shuhua Zhang,* Yanhui Li,* Huayu Tian*. pH-Responsive Natural Polymeric Gene Delivery Shielding System Based on Dynamic Covalent Chemistry[J]. ACS Biomaterials Science & Engineering. 2018, 4: 193-199. Yanwei Li, Qian Duan*, Hengguo Wang, Bo Gao, Nannan Qiu, Yanhui Li*. Construction of two-dimensional porphyrin-based fully conjugated microporous polymers as highly efficient photocatalysts. Journal of Photochemistry and Photobiology A: Chemistry. 2018, 356, 370-378. YanHui Li, Dehai Zhao, Yanwei Li, Yongzhe Liu, Qian Duan, Toyoji Kakuchi. Synthesis of water-soluble and thermoresponsive phthalocyanine ended block copolymers as potential photosensitizer[J]. Dyes & Pigments, 2017,142:88-99. YunFei Han, Qian Duan, YanHui Li*, Jian Tian*. In vitro and in vivo investigation of chitosan–polylysine polymeric nanoparticles for ovalbumin and CpG co-delivery[J]. Rsc Advances, 2017, 7(63):39962-39969. Yanhui Li, Lidan Liu, Chang Xu, Lin Lin, Qian Duan, Huayu Tian. Synthesis of multibranched poly(N-isopropylacrylamide) with aminoporphyrin core for photodynamic therapy[J]. Journal of Controlled Release, 2017, 259:e167-e168. YunFei Han, Qian Duan, Yanwei Li, YanHui Li*, Jian Tian*. Preparation and Characterization of Chitosan-Based Nanoparticles as Protein Delivery System[J]. Advances in Polymer Technology, 2016. Li Yanhui, Zhang Jingpeng, Zhang Wei, Tian Huayu*, Chen Xuesi. Novel microcapsules for drug and gene delivery.[J]. Journal of Controlled Release, 2015, 213:e130-e131. Wei Zhang, Hang Sun, Shengyan Yin*, Jingjing Chang, Yanhui Li*, Xingyuan Guo, Zhen Yuan. Bright red-emitting polymer dots for specific cellular imaging[J]. J Mater Sci, 2015, 50:1-7. Guan Xiuwen, Li Yanhui*, Jiao Zixue, Lin Lin, Chen Jie, Guo Zhaopei, Tian Huayu*, Chen Xuesi. Co-Delivery of Antitumor Drug and Gene by a pH-sensitive Charge-Conversion System. ACS Applied Materials & Interfaces. 2015,7:3207-3215. Lin yuan Cui, Yanhui Li*, Wei Zhang, Jingpeng Zhang, Qian Duan. Hyaluronic Acid Functionalized Porous Silica Nanoparticles for Drug Delivery and Release. Advanced Materials Research. 2014, 936:322-326. Guan Xiuwen, Li Yanhui*, Jiao Zixue, et al. A pH-sensitive charge-conversion system for doxorubicin delivery. Acta biomaterialia, 2013, 9: 7672–7678. Yang Yang, Yanhui Li, Nannan Qiu, Guihua Cui, Toshifumi Satoh, Qian Duan*. Synthesis and Characterization of Aminoporphyrin- End-Functionalized Poly (N- isopropylacrylamide) with Photodynamic and Thermoresponsive Effects. Chemistry- An Asian Journal. 2014, 9(5): 1379–1387. Qiu Nannan, Li Yanhui, Han Shuangli, Satoh oshifumi, Kakuchi Toyoji, Duan Qian*. Synthesis of End-Functionalized Poly(N-isopropyl acrylamide) with Zinc Porphyrin and Its Photocatalytic Activity Under Visible Light. Journal of Applied Polymer Science. 2014, 131(15). Qiu Nannan, Li Yanhui, Han Shuangli, Cui Guihua, Satoh oshifumi, Kakuchi Toyoji, Duan Qian*. Synthesis of star poly(N-isopropylacrylamide) with end-group of zinc-porphyrin via ATRP and its photocatalytic activity under visible light. Journal of Photochemistry and Photobiology A-Chemistry. 2014, 283:38-44. Yuan Cui, Yanhui Li, Qian Duan*, Toyoji Kakuchi. Preparation of Hyaluronic Acid Micro-Hydrogel by Biotin–Avidin-Specific Bonding for Doxorubicin-Targeted Delivery. Applied Biochemistry and Biotechnology. 2013, 169:239 -249. Guihua Cui, Yanhui Li, Tiantian Shi, Zhengguo Gao, Nannan Qiu, Toshifumi Satoh, Toyoji Kakuchi, Qian Duan*. Synthesis and characterization of Eu(III) complexes of modified cellulose and poly(N-isopropylacrylamide). Carbohydrate Polymers. 2013,94:77– 81. Cui Yuan, Li Yanhui, Duan qian. Study of Collagen Assemble into Gel In Situ Used as Tissue Engineering Scaffold，Advanced Materials Research, 2012，466-467：146-151. Cui Yuan, Li Yanhui, Duan qian. Study of Collagen Assemble into Gel In Situ Used as Tissue Engineering Scaffold，Advanced Materials Research, 2012，466-467：146-151. Zhaopei Guo, Yanhui Li, Huayu Tian, Xiuli Zhuang, Xuesi Chen, Xiabin Jing. Self-assembly of hyperbranched multiarmed PEG-PEI-PLys(Z) copolymer into micelles, rings, and vesicles. Langmuir. 2009, 25(17):9690-9696. Yanhui Li, Yudong Huang. The Study of Collagen Immobilization on Polyurethane by Oxygen Plasma Treatment to Enhance Cell Adhesion and Growth. Surface and Coatings Technology. 2007, 201: 5124-5127.