个人简历

教育背景 医学博士，1997年 华中科大同济医学院（原同济医科大学)。 工作经历 1994-1995年：华中科大同济医学院基础医学院免疫室，助教; 1997-1999年：北京大学医学部免疫系, 人类基因疾病中心，博士后； 1999-2004年：美国国立健康研究院（NIH），美国国家癌症研究所（NCI）, 分子免疫调节实验室， 访问学者(1999-2001), 科学家 (2001-2004, Basic Research Program, SAIC-Frederick)； 2004-2006年：美国约翰霍普金斯大学医学院， Faculty member，助理研究员； 2006-2011年： 美国Qiagen-SABiosciences，资深科学家； 2012- ： 交通大学理学院生命科学与生物工程研究院， 教授； 2013- ： 美国NCI， Cancer & Inflammation Program, 合作研究员

研究领域

生物化学与分子生物学 细胞生物学

近期论文

Lin S, Wang X, Pan Y, Tian R, Lin B, Jiang GS, Chen K, He YQ, Zhang L, Zhai W, Jin P, Yang L, Li G, Wu Y, Hu J, Gong W, Chang Z, Sheng JQ, Lu Y, Wang JM, Huang J . Transcription Factor Myeloid Zinc-Finger 1 Suppresses Human GastricCarcinogenesis by Interacting with Metallothionein 2A. Clin Cancer Res. 2018 Oct 9. pii: clincanres.1281.2018. doi: 10.1158/1078-0432.CCR-18-1281. [Epub ahead of print] PubMed PMID: 30301827.
Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, H Badger J, O'hUigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM. The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance. J Immunol. 2018 Mar. 15;200(6):2174-2185.
Wang XF，Chen K, Yu Y，Xiang Y， Kim JH，Gong W，Huang J，Shi S， LiQ，Zhou M，Sayers T, Tewary P, Gao B, and Wang JM. Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib. Oncotarget, 2017, Vol. 8, (No. 65), pp: 109068-109078.
Lin B, Zhou X, Lin S, Wang X, Zhang M, Cao B, Dong Y, Yang S, Wang JM, Guo M, Huang （corresponding author）. Epigenetic silencing of PRSS3 provides growth and metastasis advantage for human hepatocellular carcinoma. J Mol Med (Berl). 2017; 95 (11): 1237-1249。
Jiao YY, Fu YH, Yan YF, Hua Y, Ma Y, Zhang XJ, Song JD, Peng XL, Huang J, Hong，T, He JS. A single intranasal administration of virus-like particle vaccine induces an efficient protection for mice against human respiratory syncytial virus. Antiviral Res. 2017 Aug; 144:57-69.
Lin S, Lin B, Wang X, Pan Y, Xu Q, He JS, Gong W, Xing R, He Y, Guo L, Lu Y, Wang JM, Huang (corresponding author）. Silencing of ATP4B of ATPase H(+)/K(+) Transporting Beta Subunit by Intragenic Epigenetic Alteration in Human Gastric Cancer Cells. Oncol Res. 2017 Mar 13;25(3):317-329.
Pan Y, Lin S, Xing R, Zhu M, Lin B, Cui J, Li W, Gao J, Shen L, Zhao Y, Guo M, Wang JM, Huang J (corresponding author), Lu Y: Epigenetic upregulation of metallothionein 2a by diallyl trisulfide enhances chemosensitivity of human gastric cancer cells to docetaxel through attenuating nf-kappab activation. Antioxid Redox Signal 2016; 24 (15): 839-854.
Xiang Y, Yao X, Chen K, Wang X, Zhou J, Gong W, Yoshimura T, Huang J, Wang R, Wu Y, Shi G, Bian X, Wang J. The G-protein coupled chemoattractant receptor FPR2 promotes malignant phenotype of human colon cancer cells. Am J Cancer Res. 2016; 6 (11):2599-2610.
Xing R, Li L, Chen L, Gao Z, Wang H, Li W, Cui J, Tian G, Liang Q, Yu J, Sung JJ, Luo G, Gao H, Xu X, Yang H, Wang J, Zhang X, Wang JM, Huang J, Yu Y, Wang J, Lu Y. Copy number variations of HLA-I and activation of NKp30 pathway determine the sensitivity of gastric cancer cells to the cytotoxicity of natural killer cells. Oncogene. 2016 May 19;35(20):2584-91.
Guo L, Bai H, Zou D, Hong T, Liu J, Huang J, He P, Zhou Q, He J. The role ofmicroRNA-133b and its target gene FSCN1 in gastric cancer. J Exp Clin Cancer Res. 2014 Nov 30;33(1):99.
Chen K, Xiang Y, Huang J, Gong W, Yoshimura T, Jiang Q, Tessarollo L, Le Y, Wang JM. The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation. J Biol Chem. 2014 Jun 20; 289 (25): 17553-63.
Pan Y*, Huang J*, (*Co-first author), Xing R et al. Metallothionein 2A inhibits NF-kappaB pathway activation and predicts clinical outcome segregated with TNM stage in gastric cancer patients following radical resection. J Transl Med. 2013; 11: 173.
Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y. IL-7Rapha deficiency in p53(null) mice exacerbates thymocyte telomere erosion and lymphomagenesis. Cell Death Differ. 2012; 19: 1139-51.
Hamano, R., Huang, J., Toshimura, T., Howard, O.M. Z., Oppenheim, J.J., Chen, X. TNF induces co-stimulatory TNF receptor superfamily member TNFR2, 4-1BB andOX40 on CD4+FoxP3+ regulatory T cells. Eur. J. Immunol. 2011; 41: 2010-20.
Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. Proc Natl Acad Sci U S A. 2011; 108: 5626-31.
Huang, J.（corresponding author）, Quellhorst, G.J., Gu, X. Xiang, Y., Zeng, X., Boon., K., An innovative approach for profiling of histone modification marks and gene expression across a panel of oncogenes and tumor suppressor genes in multiple cancer cell lines. Cancer Research 2010 70（8）：Supplement, pp. LB-140.
Song, B. Zeng X., Blanchard, R., Huang J. （corresponding author）. A fast ChIP approach to integrated analysis of epigenetic and transcriptional regulation in multiple cancer cell types. Cancer Research 2009 69（9）： Supplement, pp. 5211.