个人简历

杨昭，男，副教授（见习），硕士生导师。2018年9月进入北京化工大学生命科学与技术学院工作。研究方向为肿瘤标志物与肿瘤靶向药物，包括肿瘤干细胞、新型基因编辑系统的建立和肿瘤免疫治疗。相关研究成果发表在European Urology、Cell Research、Journal of Experimental Medicine、Cancer Research和Clinical Cancer Research等国际学术期刊，共计SCI论文12篇。研究成果多次被领域权威期刊Nature Reviews Genetics，Nature Immunology，European Urology和Nature Reviews Urology等做亮点报道和引用。申请中国发明专利9项。承担国家自然基金青年科学基金1项；参与国家重点研发计划-干细胞及转化研究重点专项1项，参编学术专著2部。 教育背景： 2010.9-2015.6 中国科学院生物物理研究所 博士 2006.9-2010.6 吉林大学 生命科学学院 学士 工作经历： 2018.9至今 北京化工大学 生命科学与技术学院 副教授 2015.7-2018.8中国科学院微生物研究所 助理研究员 学术兼职： 1）中国生物工程学会-青年工作委员会-委员 2）北京肿瘤病理精准诊断研究会-常委 3）深圳市医师学会-精准医学专业委员会-委员

研究领域

1） 肿瘤标志物与肿瘤抗体药物2） 肿瘤干细胞与肿瘤免疫治疗3） 基因编辑

近期论文

1. Zhao Yang#, Ruiyun Zhang#, Yunxia Ge, Xuying Qin, Xing Kang, Yue Wang, Xu Zhang, Chengli Song, Xiaofang Quan, Haifeng Wang, Haige Chen* and Chong Li*. Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy. EBioMedicine. 2018, 22. pii: S2352-3964(18)30218-4.
2. Zhao Yang, Luyun He, Kaisu Lin, Yun Zhang, Aihua Deng, Yong Liang, Chong Li*, and Tingyi Wen*. The KMT1A-GATA3-STAT3 circuit is a novel self-renewal signaling of human bladder cancer stem cells. Clin Cancer Res. 2017, 1;23(21):6673-6685.
3. Chong Li#, Song Wu#, Zhao Yang#, Xiaolong Zhang#, Qi Zheng, Ling Lin, Zexiong Niu, Ruiqiang Li, Zhiming Cai and Lei Li*. Single-cell exome sequencing identifies KCP, LOC440040, and LOC440563 as driver genes in renal cell carcinoma stem cells. Cell Res. 2017, 27(4):590-593.
4. Zhao Yang#, Chong Li#, Zusen Fan#, Hongjie Liu#, Xiaolong Zhang#, Zhiming Cai#, Liqin Xu, Jian Luo, Yi Huang, Luyun He, Chunxiao Liu and Song Wu*. Single-cell sequencing reveals variants in ARID1A, GPRC5A and MLL2 driving self-renewal of human bladder cancer stem cells. Eur Urol. 2017,71(1):8-12.
5. Zhao Yang#, Shengwu Liu#, Mingao Zhu, Hong Zhang, Ji Wang, Qian Xu, Kaisu Lin, Xiumin Zhou, Min Tao, Chong Li* and Hong Zhu*. PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway. Sci Rep. 2016, 26;6:22090.
6. Chong Li#, Ying Du#, Zhao Yang#, Luyun He, Yanying Wang, Lu Hao, Mingxia Ding, Ruping Yan, Jiansong Wang, and Zusen Fan*. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016, 1;76(5):1273-83.
7. Youcheng Lin#, ZhaoYang#, Abai Xu#, Pei Dong, Yi Huang, Huan Liu, Feida Li, Haifeng Wang, Qian Xu, Yongqiang Wang, Da Sun, Yong Zou, Xiaowen Zou, Yu Wang, Duo Zhang, Hongjie Liu, Xun Wu, Meng Zhang, Yu Fu, Zhiming Cai, Chunxiao Liu* and Song Wu*. PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway. Sci Rep. 2015, 11;5:8997.
8. Buqing Ye#, Chong Li#, Zhao Yang#, Yanying Wang, Junfeng Hao, Li Wang, Yi Li, Ying Du, Lu Hao, Benyu Liu, Shuo Wang, Pengyan Xia, Guanling Huang, Lei Sun, Yong Tian* and Zusen Fan*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014, 17;211(12):2439-54.
9. Chong Li, Zhao Yang, Ying Du, Haidong Tang, Jun Chen, Deqing Hu and Zusen Fan*. BCMab1, A Monoclonal Antibody against Aberrantly Glycosylated Integrin a3b1, Has Potent Antitumor Activity of Bladder Cancer In Vivo. Clin Cancer Res. 2014, 1;20(15):4001-13.