个人简历

教育背景： 2013.8-2018.5 The Scripps Research Institute 博士（生物与生物医学科学专业） 2008.8-2012.7 清华大学 化学系，学士（化学生物学专业） 工作经历： 2012.7-2013.6 清华大学 研究助理 2018.7-至今 北京化工大学生命科学与技术学院，副教授

研究领域

蛋白与蛋白/多肽/小分子相互作用 蛋白的定向改造 神经退行性疾病机理与抑制剂研究 免疫检查点蛋白的多肽与小分子抑制剂开发

近期论文

1. Xue, S., Javor, S., Hixon, M. S., & Janda, K. D. * (2014). Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity. Biochemistry, 53(43), 6820-6824.
2. Xue, S., Schlosburg, J. E., & Janda, K. D. * (2015). A new strategy for smoking cessation: Characterization of a bacterial enzyme for the degradation of nicotine. Journal of the American Chemical Society, 137(32), 10136-10139.
3. Seki, H., Xue, S., Hixon, M. S., Pellett, S., Remes, M., Johnson, E. A., & Janda, K. D. * (2015). Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity. Chemical Communications, 51(28), 6226-6229.
4. Seki, H.1, Xue, S.1, Pellett, S., Šilhár, P., Johnson, E. A., & Janda, K. D. * (2016). Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism. Journal of the American Chemical Society, 138(17), 5568-5575.
5. Bremer, P. T., Xue, S., & Janda, K. D. * (2016). Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain. Chemical Communications, 52(84), 12521-12524.
6. Xue, S., Seki, H., Remes, M., Šilhár, P. & Janda, K. D. * (2017). Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid. Bioorganic & Medicinal Chemistry Letters, 27(22), 4956-4959.
7. Xue, S.1, Kallupi M.1, Zhou B., Smith, L. C., Miranda, P. O., George, O., & Janda, K. D. * (2018). An Enzymatic Advance in Nicotine Cessation Therapy. Chemical Communications, 54 (14), 1686-1689 (front cover).
8. Tararina, M.1, Xue, S.1, Smith, L. C., Muellers, S., Miranda, P. O., Janda, K. D., & Allen, K. * (2018). Crystallography Coupled with Kinetic Analysis Provide Mechanistic Underpinnings of a Nicotine-Degrading Enzyme. Submitted to Biochemistry, 57 (26): 3741–3751.
9. Kallupi M.1*, Xue, S.1, Zhou B., George, O.*, & Janda, K. D. (2019) Enzymatic approach to reverse nicotine dependence, decrease compulsive-like intake, and prevent relapse. Science Advances, 4 (10), eaat4751.
10. Chen, C., Ding, X., Akram, N., Xue, S. *, & Luo, S. Z. * (2019). Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases. Molecules, 24(8), 1622.