王磊
近期热点
资料介绍
个人简历
教育背景: 2000.9-2004.6 厦门大学生命科学学院,理学学士 (生物学专业) 2004.9-2013.1 清华大学生命科学学院,理学博士(生物学专业) 2008.9-2010.2 美国纽约冷泉港实验室, 联合培养博士生 2017.12-2019.6 美国麻省大学医学院, 访问学者 工作经历: 2013.4-2014.12 北京化工大学生命科学与技术学院,讲师 2015.1-至今 北京化工大学生命科学与技术学院,副教授研究领域
1.利用转基因动物模型进行神经退行性疾病的分子机制研究与药物筛选。2.利用人源肿瘤异种移植模型(Patient-Derived tumor Xenograft,PDX)进行肿瘤发生机制的研究和药物筛选。3.肿瘤的免疫治疗。近期论文
1 Chen YR, Li YH, Hsieh TC, Wang CM, Cheng KC, Wang L, Lin TY, Cheung CHA, Wu CL, Chiang H,Aging-induced Akt activation involves in aging-related pathologies and Aβ-induced toxicity. Aging Cell, 18(4), e12989, 2019.2 Wang Lei*, Liang Bin and Zhong Yi*, Reduced EGFR level potentially mediates the Aβ42-induced neuronal loss in transgenic fruit fly and mouse, Protein Cell, 4(9), 647–649, 2013.(共同通讯作者)3 Lang Minglin, Fan Qiangwang, Wang Lei, Zheng Yajun, Xiao Guiran, Wang Xiaoxi, Wang Wei, Zhong Yi, Zhou Bing*, Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42- induced Alzheimer’s disease-like symptoms, Neurobiol Aging, 34(11), 2604-2612, 2013.(并列第一作者)4 Wang Lei, Chiang Hsueh-Cheng, Wu Wenjuan, Liang Bin, Xie Zuolei, Yao Xinsheng, Ma Weiwei, Du Shuwen, Zhong Yi*, Epidermal growth factor is a preferred target for treating amyloid-β induced memory loss, Proc Natl Acad Sci U S A, 109(41), 16743-16748, 2012.5 Lang Minglin, Wang Lei, Fan Qiangwang, Xiao Guiran, Wang Xiaoxi, Zhong Yi, Zhou Bing*, Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates Aβ pathology in a Drosophila model of Alzheimer’s disease, PLoS Genet, 8(4), e1002683, 2012. (并列第一作者)6 Chiang Hsueh-Cheng, Wang Lei, Xie Zuolei, Yau Alice, Zhong Yi*, PI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila, Proc Natl Acad Sci U S A, 107(15), 7060-7065, 2010. (并列第一作者) 相关热点