个人简历

教育背景： 2009/09 – 2013/06，北京化工大学，生命科学与技术学院，博士 2011/02 – 2012/05，University of Georgia，生命科学与农业系，联合培养博士 2006/09 – 2009/07，北京化工大学，生命科学与技术学院，硕士 2002/09 – 2006/07，华中科技大学，生命科学与技术学院，学士 工作经历： 2013.7-今 北京化工大学生命科学与技术学院，讲师，硕士生导师

研究领域

通过合成生物学及代谢工程方法，实现以大肠杆菌，酿酒酵母为平台的天然活性成分和大宗化学品的生产，主要研究方向包括： 1.天然活性成分及大宗化学品的生物合成与代谢调控； 2.酶工程； 3.非天然底物的生物利用。

近期论文

1. Xiaolin Shen1, Jia Wang, Chenyi Li, Qipeng Yuan, Yajun Yan*. Dynamic gene expression engineering as a tool in pathway engineering. Current opinion in Biotechnology, 2019, 59, 122-129. (1区TOP, IF=8.383)
2. Xiaolin Shen1, Dayong Zhou, Yuheng Lin, Jia Wang, Shuaihua Gao, Palani Kandavelu, Hua Zhang, Ruihua Zhang, Bi-Cheng Wang, John Rose, Qipeng Yuan, Yajun Yan. Structural Insights into Catalytic Versatility of the Flavin-dependent Hydroxylase (HpaB) from Escherichia coli. Scientific Reports. 2019, 9, 7087-7097. (IF=4.122)
3. Xiaolin Shen1, Jia Wang1, Bradley K. Gall, Eric M. Ferreira, Qipeng Yuan*, Yajun Yan*. Establishment of novel biosynthetic pathways for the production of salicyl alcohol and gentisyl alcohol in engineered Escherichia coli. 并列一作，ACS Synthetic Biology, 2018, 7(4),1012-1017. (IF=5.382)
4. Jia Wang1, Xiaolin Shen1, Jian Wang, Yaping Yang, Qipeng Yuan*, Yajun Yan*. Exploring the promiscuity of phenol hydroxylase from Pseudomonas stutzeri OX1 for the biosynthesis of phenolic compounds. 并列一作，ACS Synthetic Biology, 2018, 7:1238-1243. (IF=5.382)
5. Xiaolin Shen1, Jia Wang, Jian Wang, Zhenya Chen, Qipeng Yuan*, Yajun Yan*. High-level De novo Biosynthesis of Arbutin in Engineered Escherichia coli. Metabolic Engineering, 2017, 42, 52-58. (1区TOP, IF=8.201)
6. Xiaolin Shen1, Monika Mahajani1, Jia Wang, Yaping Yang, Qipeng Yuan, Yajun Yan*, Yuheng Lin*. Elevating 4-Hydroxycoumarin Production through Alleviating Thioesterase- mediated Salicoyl-CoA Degradation. 并列一作，Metabolic Engineering, 2017, 42, 59-65. (1区TOP, IF=8.201)
7. Jia Wang, Xiaolin Shen*. Engineering Microbial Metabolism for Chemical Synthesis – Reviews and Perspectives. Chapter 2: Citric Acid Cycle and Its Metabolic Engineering Applications. (专著，通讯作者)
8. Xinxiao Sun1, Xiaolin Shen1, Rachit Jain, Yuheng Lin, Jian Wang, Jing Sun, Jia Wang, Yajun Yan*, Qipeng Yuan*. Synthesis of Chemicals by Metabolic Engineering of Microbes. Chemical Society Reviews,2015, 44, 3760-3785.（IF=33.383）
9. Jing Sun1, Yuheng Lin1, Xiaolin Shen1, Rachit Jain, Xinxiao Sun, Qipeng Yuan, Yajun Yan. Aerobic biosynthesis of hydrocinnamicacids in Escherichia coli with a strictly oxygen-sensitive enoate reductase. Metabolic Engineering, 2016, 35: 75-82. (1区TOP, IF=8.201)
10. Xiaolin Shen, Yuheng Lin, Rachit Jain, Qipeng Yuan, Yajun Yan*. Inhibition of acetate accumulation leads to enhanced production of (R,R)-2,3-butanediol from glycerol in Escherichia coli. Journal of Industrial Microbiology & Biotechnology, 2012, 39(11),1725-1729.
11. Yuheng Lin, Xiaolin Shen, Qipeng Yuan & Yajun Yan. Microbial biosynthesis of the anticoagulant precursor 4-hydroxycoumarin. Nature Communications. 2013, DOI: 10.1038/ncomms3603. (IF=12.353)